Zobrazeno 1 - 10
of 110
pro vyhledávání: '"David J Reiss"'
Autor:
Samuel A Danziger, Mark McConnell, Jake Gockley, Mary H Young, Adam Rosenthal, Frank Schmitz, David J Reiss, Phil Farmer, Daisy V Alapat, Amrit Singh, Cody Ashby, Michael Bauer, Yan Ren, Kelsie Smith, Suzana S Couto, Frits van Rhee, Faith Davies, Maurizio Zangari, Nathan Petty, Robert Z Orlowski, Madhav V Dhodapkar, Wilbert B Copeland, Brian Fox, Antje Hoering, Alison Fitch, Katie Newhall, Bart Barlogie, Matthew W B Trotter, Robert M Hershberg, Brian A Walker, Andrew P Dervan, Alexander V Ratushny, Gareth J Morgan
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
BackgroundThe tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, wh
Externí odkaz:
https://doaj.org/article/48a59d8f2fb64baa9b747522459ffea9
Autor:
Samuel A Danziger, David L Gibbs, Ilya Shmulevich, Mark McConnell, Matthew W B Trotter, Frank Schmitz, David J Reiss, Alexander V Ratushny
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224693 (2019)
Immune cell infiltration of tumors and the tumor microenvironment can be an important component for determining patient outcomes. For example, immune and stromal cell presence inferred by deconvolving patient gene expression data may help identify hi
Externí odkaz:
https://doaj.org/article/c210f3640b084ae4b0efafef16177ca4
Autor:
Serdar Turkarslan, Arjun V Raman, Anne W Thompson, Christina E Arens, Mark A Gillespie, Frederick vonNetzer, Kristina L Hillesland, Sergey Stolyar, Adrian López García de Lomana, David J Reiss, Drew Gorman‐Lewis, Grant M Zane, Jeffrey A Ranish, Judy D Wall, David A Stahl, Nitin S Baliga
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 3, Pp n/a-n/a (2017)
Abstract Managing trade‐offs through gene regulation is believed to confer resilience to a microbial community in a fluctuating resource environment. To investigate this hypothesis, we imposed a fluctuating environment that required the sulfate‐r
Externí odkaz:
https://doaj.org/article/a655ac4e70d1467cac12e10d18846903
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107863 (2014)
Widespread microbial genome sequencing presents an opportunity to understand the gene regulatory networks of non-model organisms. This requires knowledge of the binding sites for transcription factors whose DNA-binding properties are unknown or diffi
Externí odkaz:
https://doaj.org/article/4f9d4b8833fd4567821895a363f7d132
Autor:
Amardeep Kaur, Phu T Van, Courtney R Busch, Courtney K Robinson, Min Pan, Wyming Lee Pang, David J Reiss, Jocelyne DiRuggiero, Nitin S Baliga
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Complexity of cellular response to oxidative stress (OS) stems from its wide‐ranging damage to nucleic acids, proteins, carbohydrates, and lipids. We have constructed a systems model of OS response (OSR) for Halobacterium salinarum NRC‐1 in an at
Externí odkaz:
https://doaj.org/article/25d4cd03e36c4faf823a511fea3d9bbc
Autor:
Brian A. Fox, Kathryn J. Newhall, Candice McCoy, Jeremy S. Abramson, Yeonhee Kim, Jerill Thorpe, David J. Reiss, Seamus P. Ragan, N. Eric Olson
Supplementary Methods; Supplementary Figures S1-S9; Supplementary Tables S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191b83d855590b5ceebe2e4af6e82262
https://doi.org/10.1158/1535-7163.22523172.v1
https://doi.org/10.1158/1535-7163.22523172.v1
Autor:
Peter J. O'Dwyer, Teng Jin Ong, Chrystal U. Louis, Larry Lyons, Sibabrata Banerjee, Rafia Bhore, Daniel W. Pierce, David J. Reiss, Thomas Lila, Hatem H. Soliman, Daniel Ricardo Carrizosa, Rishi Jain, Aparna Parikh, Martin Guiterrez, David M. Waterhouse, E. Gabriela Chiorean, Aparna Kaylan, Ben George, Edward J. Kim, Howard S. Hochster, Zev A. Wainberg
Investigator-assessed PFS and OS in patients with PD-L1 expression cutoff of 1% (A, B) or 5% (C, D). HR, hazard ratio; mo, months; OS, overall survival; PD-L1, programmed cell death ligand-1; PFS, progression-free survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e9db745e67db99e4742619e1ece12c
https://doi.org/10.1158/1078-0432.22475435.v1
https://doi.org/10.1158/1078-0432.22475435.v1
Autor:
Peter J. O'Dwyer, Teng Jin Ong, Chrystal U. Louis, Larry Lyons, Sibabrata Banerjee, Rafia Bhore, Daniel W. Pierce, David J. Reiss, Thomas Lila, Hatem H. Soliman, Daniel Ricardo Carrizosa, Rishi Jain, Aparna Parikh, Martin Guiterrez, David M. Waterhouse, E. Gabriela Chiorean, Aparna Kaylan, Ben George, Edward J. Kim, Howard S. Hochster, Zev A. Wainberg
Patients were enrolled in Arm B Part 1 after the safety oversight committee deemed Arm A Part 1 safe. DRC, data review committee; LAPC, locally advanced pancreatic cancer; MPC, metastatic pancreatic cancer; RP2D, recommended Part 2 dose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898ef1dea38981f86f8ebf1a7d51ab9a
https://doi.org/10.1158/1078-0432.22475438
https://doi.org/10.1158/1078-0432.22475438
Autor:
Peter J. O'Dwyer, Teng Jin Ong, Chrystal U. Louis, Larry Lyons, Sibabrata Banerjee, Rafia Bhore, Daniel W. Pierce, David J. Reiss, Thomas Lila, Hatem H. Soliman, Daniel Ricardo Carrizosa, Rishi Jain, Aparna Parikh, Martin Guiterrez, David M. Waterhouse, E. Gabriela Chiorean, Aparna Kaylan, Ben George, Edward J. Kim, Howard S. Hochster, Zev A. Wainberg
Concentrations of CXCL10 (A) and sIL2Rα (B) at baseline and peak on-treatment values. Investigator-assessed PFS in patients with high or low serum cytokines CXCL10 (C) and sIL2Rα (D). CXCL10, interferon gamma-induced protein 10; mo, months; NE, not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b40b6e000cad2b036744f48c00548a3
https://doi.org/10.1158/1078-0432.22475420.v1
https://doi.org/10.1158/1078-0432.22475420.v1
Autor:
Peter J. O'Dwyer, Teng Jin Ong, Chrystal U. Louis, Larry Lyons, Sibabrata Banerjee, Rafia Bhore, Daniel W. Pierce, David J. Reiss, Thomas Lila, Hatem H. Soliman, Daniel Ricardo Carrizosa, Rishi Jain, Aparna Parikh, Martin Guiterrez, David M. Waterhouse, E. Gabriela Chiorean, Aparna Kaylan, Ben George, Edward J. Kim, Howard S. Hochster, Zev A. Wainberg
Baseline (screening) vs treatment cycle 2 (P=.06; paired t test). For patient 5, baseline data were not available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd98b63eb49f579d01cbe44a0a85231
https://doi.org/10.1158/1078-0432.22475423
https://doi.org/10.1158/1078-0432.22475423