Zobrazeno 1 - 10
of 147
pro vyhledávání: '"David J Reiner"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
AbstractDevelopment of the Caenorhabditis eleganslag-1C. elegans
Externí odkaz:
https://doaj.org/article/0f2f2b247f7242ee87f59b0e9a8b4e73
Autor:
Katherine H Pedone, Vanessa González-Pérez, Luciana E Leopold, Neal R Rasmussen, Channing J Der, Adrienne D Cox, Shawn Ahmed, David J Reiner
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 9 (2021)
AbstractUsing model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of a
Externí odkaz:
https://doaj.org/article/c7c88b8ef42d4728ba9e8e9a3815be33
Autor:
Sarah M. Claypool, David J. Reiner, Sana Behdin, Javier Orihuel, Ashley Batista, Kiera E. Caldwell, Jonathan J. Chow, Jennifer M. Bossert, F. Javier Rubio, Bruce T. Hope, Yavin Shaham
Publikováno v:
The Journal of Neuroscience. 43:2597-2614
We previously demonstrated a role of piriform cortex (Pir) in relapse to fentanyl seeking after food choice-induced voluntary abstinence. Here, we used this model to further study the role of Pir and its afferent projections in fentanyl relapse. We t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::427e41d055dac4bf5f98bbc5ba54c4f2
https://doi.org/10.1523/jneurosci.0034-23.2023
https://doi.org/10.1523/jneurosci.0034-23.2023
Autor:
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
Publikováno v:
The Journal of Neuroscience. 43:1692-1713
The brain µ-opioid receptor (MOR) is critical for the analgesic, rewarding, and addictive effects of opioid drugs. However, in rat models of opioid-related behaviors, the circuit mechanisms of MOR-expressing cells are less known because of a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe7ae4967be9d95039228d09b7a62b2
https://doi.org/10.1523/jneurosci.2049-22.2023
https://doi.org/10.1523/jneurosci.2049-22.2023
Autor:
Hanna Shin, Christian Braendle, Kimberly B Monahan, Rebecca E W Kaplan, Tanya P Zand, Francisca Sefakor Mote, Eldon C Peters, David J Reiner
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008056 (2019)
The six C. elegans vulval precursor cells (VPCs) are induced to form the 3°-3°-2°-1°-2°-3° pattern of cell fates with high fidelity. In response to EGF signal, the LET-60/Ras-LIN-45/Raf-MEK-2/MEK-MPK-1/ERK canonical MAP kinase cascade is necess
Externí odkaz:
https://doaj.org/article/521bff2dae7e4e9899ac45a0b40517f7
Autor:
Ida Fredriksson, Pei-Jung Tsai, Aniruddha Shekara, Ying Duan, Sarah V. Applebey, Angelica Minier-Toribio, Ashley Batista, Jonathan J. Chow, Lindsay Altidor, Estelle Barbier, Carlo Cifani, Xuan Li, David J. Reiner, F. Javier Rubio, Bruce T. Hope, Yihong Yang, Jennifer M. Bossert, Yavin Shaham
High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd72e97aee84d70276cd8053e48c863
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191360
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191360
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2669-2681.e5 (2018)
Summary: C. elegans vulval precursor cell (VPC) fates are patterned by an epidermal growth factor (EGF) gradient. High-dose EGF induces 1° VPC fate, and lower dose EGF contributes to 2° fate in support of LIN-12/Notch. We previously showed that the
Externí odkaz:
https://doaj.org/article/8d750170ac3f4c89af74177e8bd0f313
Publikováno v:
Dev Biol
Ras is the most commonly mutated oncogene in humans and uses three oncogenic effectors: Raf, PI3K, and RalGEF activation of Ral. Understanding the importance of RalGEF>Ral signaling in cancer is hampered by the paucity of knowledge about their functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c02460a6f98d94aae9d02ccd27b946
https://doi.org/10.1016/j.ydbio.2021.05.004
https://doi.org/10.1016/j.ydbio.2021.05.004
Autor:
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
The brain µ-opioid receptor (MOR) is critical for the analgesic, rewarding, and addictive effects of opioid drugs. However, in rat models of opioid-related behaviors, the circuit mechanisms of MOR-expressing cells are less known because of a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2d43e95e8230d1fbe7e3799e7f89ec
https://doi.org/10.1101/2022.11.02.514895
https://doi.org/10.1101/2022.11.02.514895
Autor:
Jennifer M. Bossert, Yavin Shaham, Marco Venniro, Ida Fredriksson, Jonathan J Chow, David J. Reiner
Publikováno v:
Pharmacological Reviews. 73:1050-1083
Relapse to drug use during abstinence is a defining feature of addiction. During the last several decades, this clinical scenario has been studied at the preclinical level using classic relapse/reinstatement models in which drug seeking is assessed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40d4f5b4a3a4e09df674fd36a51a7c1
https://doi.org/10.1124/pharmrev.120.000191
https://doi.org/10.1124/pharmrev.120.000191