Výsledky vyhledávání - "David J R Foster"

Akademický článek

Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats.

Autor: Jana Leshinsky, Andrew McLachlan, David J R Foster, Ross Norris, Vanessa R Barrs

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178783 (2017)

Cats are the most common mammal to develop invasive fungal rhinosinusitis caused by cryptic species in Aspergillus section Fumigati that are resistant to azoles but susceptible to caspofungin. In this study nonlinear mixed-effects pharmacokinetic mod

Externí odkaz: https://doaj.org/article/d7273d7a59b941fba84104e40c54e3de

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Akademický článek

Concomitant beta-blocker use is associated with a reduced rate of remission in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs: a multicohort analysis

Autor: Ahmad Y. Abuhelwa, David J. R. Foster, Arkady Manning-Bennett, Michael J. Sorich, Susanna Proudman, Michael D. Wiese, Ashley M. Hopkins

Publikováno v: Therapeutic Advances in Musculoskeletal Disease, Vol 13 (2021)

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with increased risk of cardiovascular disease (CVD). Treatment for CVD may involve pharmacological agents that antagonise beta adrenergic receptors. These r

Externí odkaz: https://doaj.org/article/44171b33973a47feb71abaeba9bbbccd

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Effect of Roux-en-Y gastric bypass on the pharmacokinetic-pharmacodynamic relationships of liquid and controlled-release formulations of oxycodone

Autor: Asbjørn Mohr Drewes, Grzegorz J. Pacyk, Jens Peter Kroustrup, Kenneth T. Kongstad, David J. R. Foster, Ahmad Y. Abuhelwa, Lona L. Christrup, Louise Ladebo, Anne Estrup Olesen

Publikováno v: Ladebo, L, Abuhelwa, A Y, Foster, D J R, Kroustrup, J P, Pacyk, G J, Kongstad, K T, Drewes, A M, Christrup, L L & Olesen, A E 2021, ' Effect of Roux-en-Y gastric bypass on the pharmacokinetic-pharmacodynamic relationships of liquid and controlled-release formulations of oxycodone ', Basic & Clinical Pharmacology & Toxicology, vol. 129, no. 3, pp. 232-245 . https://doi.org/10.1111/bcpt.13634

The physiological changes following Roux-en-Y gastric bypass (RYGB) surgery may impact drug release from mechanistically different controlled-release tablets, making generic substitution inappropriate. This study aimed to characterise the pharmacokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b934d490e6e88500dc8fb6a9d66a46
https://hdl.handle.net/11541.2/148124

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Physiologically based models: Techniques and applications to drug delivery

Autor: Ashley M. Hopkins, Jim H. Hughes, Richard N. Upton, David J. R. Foster, Ahmad Y. Abuhelwa

Publikováno v: Drug Delivery Approaches

Physiologically based pharmacokinetic (PBPK) models allow integrated representations of the time course of drug concentrations in the important organs and sites of drug action, toxicity, absorption, metabolism, and excretion. PBPK models have multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0431008f115b11e39b6698ddbec6e7a
https://hdl.handle.net/11541.2/27124

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Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

Autor: Kenneth T. Kongstad, Richard N. Upton, Lona L. Christrup, Louise Ladebo, Asbjørn Mohr Drewes, Ahmad Y. Abuhelwa, David J. R. Foster, Anne Estrup Olesen

Publikováno v: Ladebo, L, Foster, D J R, Abuhelwa, A Y, Upton, R N, Kongstad, K T, Drewes, A M, Christrup, L L & Olesen, A E 2020, ' Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers ', Basic & Clinical Pharmacology & Toxicology, vol. 126, no. 3, pp. 263-276 . https://doi.org/10.1111/bcpt.13330

Oral controlled-release formulations are playing an ever-increasing role in opioid therapy; however, little is known about their influence on the relationship between pharmacokinetics and pharmacodynamics. The study aim was to characterize the pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a59a0ab7a24090ab38ae7a0a5ac00cc
https://vbn.aau.dk/da/publications/1bb1198a-dee9-4c3d-a70f-6cb9813410e4

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Demonstrating contribution of components of fixed-dose drug combinations through longitudinal exposure-response analysis

Autor: Trine Meldgaard Lund, Asbjørn Nøhr-Nielsen, Richard N. Upton, David J. R. Foster, Julie Lyng Forman, Ole J. Bjerrum, Theodoros Papathanasiou, Theis Lange

Exposure-response (ER) modeling for fixed-dose combinations (FDC) has previously been found to have an inflated false positive rate (FP), i.e., observing a significant effect of FDC components when no true effect exists. Longitudinal exposure-respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492541a5a6461e303d35d3b87b547fdc
https://hdl.handle.net/11541.2/141328

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Population in vitro–in vivo pharmacokinetic model of first-pass metabolism: itraconazole and hydroxy-itraconazole

Autor: Richard N. Upton, Stuart Mudge, Ahmad Y. Abuhelwa, David J. R. Foster

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 45:181-197

The aim of this study was to develop a population in vitro–in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832356fe8f2803aed6552607ec199aba
https://doi.org/10.1007/s10928-017-9555-8

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Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats

Autor: Andrew J. McLachlan, A.S. Hanzlicek, N.J. Beijerink, M. Yata, David J. R. Foster

Publikováno v: Journal of Veterinary Cardiology. 18:310-325

Introduction To investigate the pharmacokinetics and pharmacodynamics of oral pimobendan in conscious, healthy cats. Animals Eight healthy adult cats. Materials and methods A randomised, single-blinded, crossover design was used. Two oral doses of pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55150edf45a5702c896a4623619fb7a
https://doi.org/10.1016/j.jvc.2016.07.001

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Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice

Autor: Mitch A. Phelps, Stephanie E. Reuter, Darlene M. Rozewski, David J. R. Foster, Richard N. Upton, Jim H. Hughes

Publikováno v: Cancer Chemother Pharmacol

Purpose: Lenalidomide is used widely in B-cell malignancies for its immunomodulatory activity. It is primarily eliminated via the kidneys, with a significant proportion of renal elimination attributed to active processes. Lenalidomide is a weak subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a324c361be1e21fae808d7bad17315a
https://pubmed.ncbi.nlm.nih.gov/31493176

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Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis

Autor: Mitch A. Phelps, Jim H. Hughes, David J. R. Foster, Richard N. Upton, Stephanie E. Reuter

Publikováno v: The Journal of pharmacy and pharmacologyReferences. 71(11)

Objectives The selection of sample times for a pharmacokinetic study is important when trapezoidal integration (e.g. non-compartmental analysis) is used to determine the area under the concentration–time curve (AUC). The aim of this study was to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c24ba9ac4c9b3d67f8810b848553d2
https://pubmed.ncbi.nlm.nih.gov/31412422

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