Zobrazeno 1 - 10
of 115
pro vyhledávání: '"David J Pintel"'
Autor:
Kinjal Majumder, Maria Boftsi, Fawn B Whittle, Juexin Wang, Matthew S Fuller, Trupti Joshi, David J Pintel
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009002 (2020)
The autonomous parvovirus Minute Virus of Mice (MVM) localizes to cellular DNA damage sites to establish and sustain viral replication centers, which can be visualized by focal deposition of the essential MVM non-structural phosphoprotein NS1. How su
Externí odkaz:
https://doaj.org/article/ca36a74fa9984864859e8a0a727da2f4
Autor:
Kinjal Majumder, Juexin Wang, Maria Boftsi, Matthew S Fuller, Jordan E Rede, Trupti Joshi, David J Pintel
Publikováno v:
eLife, Vol 7 (2018)
We have developed a generally adaptable, novel high-throughput Viral Chromosome Conformation Capture assay (V3C-seq) for use in trans that allows genome-wide identification of the direct interactions of a lytic virus genome with distinct regions of t
Externí odkaz:
https://doaj.org/article/79437437fcc042808e158463f3a4b2b8
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004055 (2014)
Infection by the autonomous parvovirus minute virus of mice (MVM) induces a vigorous DNA damage response in host cells which it utilizes for its efficient replication. Although p53 remains activated, p21 protein levels remain low throughout the cours
Externí odkaz:
https://doaj.org/article/f293874ba9414711b8307653daf07693
Autor:
Richard O Adeyemi, David J Pintel
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003891 (2014)
Parvoviruses halt cell cycle progression following initiation of their replication during S-phase and continue to replicate their genomes for extended periods of time in arrested cells. The parvovirus minute virus of mice (MVM) induces a DNA damage r
Externí odkaz:
https://doaj.org/article/765c3cbba5fd42b5b77896532de3783b
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001141 (2010)
Infection by DNA viruses can elicit DNA damage responses (DDRs) in host cells. In some cases the DDR presents a block to viral replication that must be overcome, and in other cases the infecting agent exploits the DDR to facilitate replication. We fi
Externí odkaz:
https://doaj.org/article/6bf81769819e4433a09e7f932d152cd7
Autor:
Iñigo Narvaiza, Daniel C Linfesty, Benjamin N Greener, Yoshiyuki Hakata, David J Pintel, Eric Logue, Nathaniel R Landau, Matthew D Weitzman
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000439 (2009)
The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of th
Externí odkaz:
https://doaj.org/article/c9be6e30441e4dc4b3b23d56c804e04b
Publikováno v:
Viruses, Vol 12, Iss 12, p 1368 (2020)
Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral genome organizatio
Externí odkaz:
https://doaj.org/article/137b4ae50f63458b8ee4115e05d6c9a3
Autor:
Lisa R. Burger, Juexin Wang, David J. Pintel, Kevin A. Kaifer, Christian L. Lorson, Fawn B. Whittle, Kinjal Majumder, Maria Boftsi, Trupti Joshi, Phoenix M. Shepherd
Publikováno v:
Hum Mol Genet
Nuclear DNA viruses simultaneously access cellular factors that aid their life cycle while evading inhibitory factors by localizing to distinct nuclear sites. Adeno-associated viruses (AAVs), which are Dependoviruses in the family Parvovirinae, are n
Autor:
David J. Pintel, Xiufang Pan, Ngoc Tam Tran, Phillip W. L. Tai, Yongping Yue, Dongsheng Duan, Maria Boftsi, Keqing Zhang, Lakmini P. Wasala
Publikováno v:
Gene therapy. 29(6)
Inverted terminal repeats (ITRs) are the only wild-type components retained in the genome of adeno-associated virus (AAV) vectors. To determine whether ITR modification is a viable approach for AAV vector engineering, we rationally deleted all CpG mo
Autor:
Fawn B. Whittle, David J. Pintel, Trupti Joshi, Matthew S. Fuller, Kinjal Majumder, Juexin Wang, Maria Boftsi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009002 (2020)
PLoS Pathogens
PLoS Pathogens
The autonomous parvovirus Minute Virus of Mice (MVM) localizes to cellular DNA damage sites to establish and sustain viral replication centers, which can be visualized by focal deposition of the essential MVM non-structural phosphoprotein NS1. How su