Zobrazeno 1 - 10
of 202
pro vyhledávání: '"David J Pinsky"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008861 (2021)
The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs. Hypoxic pulmonary vasoconstriction is understood to be the primary active regulator
Externí odkaz:
https://doaj.org/article/76dfa3895c10463eb6305ffeaeb659f3
Autor:
Scott H Visovatti, Matthew C Hyman, Diane Bouis, Richard Neubig, Vallerie V McLaughlin, David J Pinsky
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40829 (2012)
BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) is a devastating disease characterized by increased pulmonary vascular resistance, smooth muscle and endothelial cell proliferation, perivascular inflammatory infiltrates, and in situ throm
Externí odkaz:
https://doaj.org/article/7d432496c8fe4a2ca9f7e3445c8380c6
Autor:
Alison L. Banka, M. Valentina Guevara, Emma R. Brannon, Nhien Q. Nguyen, Shuang Song, Gillian Cady, David J. Pinsky, Kathryn E. Uhrich, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The combination of inflammation and thrombosis is a hallmark of many cardiovascular diseases. Under such conditions, platelets are recruited to an area of inflammation by forming platelet-leukocyte aggregates via interaction of PSGL-1 on leu
Externí odkaz:
https://doaj.org/article/caeda1dbe64e41b38302bf6fa0635e66
Autor:
Rachel G. Kroll, Corey Powell, Jun Chen, Natasha T. Snider, Cynthia St. Hilaire, Akshay Reddy, Judy Kim, David J. Pinsky, Venkatesh L. Murthy, Nadia R. Sutton
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 9 (2023)
Background Ectonucleotidases maintain vascular homeostasis by metabolizing extracellular nucleotides, modulating inflammation and thrombosis, and potentially, myocardial flow through adenosine generation. Evidence implicates dysfunction or deficiency
Externí odkaz:
https://doaj.org/article/9cb0e3342def42b2ac15ae5b602fd5ba
Autor:
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope Blakely, Ayse Bilge Ozel, Sarah Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekmulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thørner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Søren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, on behalf of the DBDS Consortium, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, on behalf of the Regeneron Genetics Center, Gunnar Engström, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with
Externí odkaz:
https://doaj.org/article/97725ccf03d44b8f8179f849f6db2e96
Autor:
Yoshiro Aoki, Natalie M. Walker, Keizo Misumi, Takeshi Mimura, Ragini Vittal, Aidan P. McLinden, Linda Fitzgerald, Michael P. Combs, Dennis Lyu, John J. Osterholzer, David J. Pinsky, Vibha N. Lama
Publikováno v:
The Journal of Heart and Lung Transplantation. 42:317-326
Small airway inflammation and fibrosis or bronchiolitis obliterans (BO) is the predominant presentation of chronic lung allograft dysfunction (CLAD) post-lung transplantation. Carbon monoxide (CO) is a critical endogenous signaling transducer with kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13432d25d555fd63f4dbd4c2e1ef40a1
https://doi.org/10.1016/j.healun.2022.11.005
https://doi.org/10.1016/j.healun.2022.11.005
Autor:
Olga G. Grushko, Steven Cho, Ashley M. Tate, Robert S. Rosenson, David J. Pinsky, Jacob M. Haus, Scott L. Hummel, Sascha N. Goonewardena
Publikováno v:
Cardiovascular Drugs and Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb1e08836ee82dfcc076360051d96b3
https://doi.org/10.1007/s10557-022-07390-4
https://doi.org/10.1007/s10557-022-07390-4
Autor:
Nadia R. Sutton, David J. Pinsky, Matthew C. Hyman, Imran M. Rashid, Daniel R. Goldstein, Diane Bouis, Alexandra L. McCubbrey, Annie Mei, Kris M. Mann
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent atherosclerosis r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73deaea98e8964f5a181ef8a9dbf92f
https://doi.org/10.1161/atvbaha.119.313002
https://doi.org/10.1161/atvbaha.119.313002
Autor:
Michael Holinstat, Anuli C. Anyanwu, Raymond Zhao, J. Michelle Kahlenberg, Sharon Koonse, Hui Liao, Yogendra Kanthi, Benjamin E. Tourdot, Benjamin N. Jacobs, Scott H. Visovatti, Srilakshmi Yalavarthi, Alison L. Banka, Liguo Chi, Vinita Yadav, David J. Pinsky, Jason S. Knight
Publikováno v:
Journal of Clinical Investigation. 129:2872-2877
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of evidence ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bcbeee03e13e4f5227c3ef48e4d2090
https://doi.org/10.1172/jci124804
https://doi.org/10.1172/jci124804
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 5, p e1008861 (2021)
PLoS Computational Biology, Vol 17, Iss 5, p e1008861 (2021)
The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs. Hypoxic pulmonary vasoconstriction is understood to be the primary active regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13f009d2859bb6b474bc1b73e0834e8
https://pubmed.ncbi.nlm.nih.gov/33956786
https://pubmed.ncbi.nlm.nih.gov/33956786