Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David J Morgans"'
Autor:
Darren T Hwee, Adam Kennedy, Julie Ryans, Alan J Russell, Zhiheng Jia, Aaron C Hinken, David J Morgans, Fady I Malik, Jeffrey R Jasper
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96921 (2014)
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years
Externí odkaz:
https://doaj.org/article/2d8b4b2563864ca697b28f372dd39e3f
Autor:
David Ho, Li Chen, Xin Zhao, Nicquanna Durham, Malar Pannirselvam, Dorothy E Vatner, David J Morgans, Fady I Malik, Stephen F Vatner, You-Tang Shen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36302 (2012)
Pulmonary hypertension remains a major clinical problem despite current therapies. In this study, we examine for the first time a novel pharmacological target, smooth muscle myosin, and determine if the smooth muscle myosin inhibitor, CK-2019165 (CK-
Externí odkaz:
https://doaj.org/article/19f0f2d84641463c8d31ccc641c431cb
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj
Externí odkaz:
https://doaj.org/article/f75a5266ef724db48db905d69406f78e
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
Publikováno v:
Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq
https://escholarship.org/uc/item/5q12m0vq
Autor:
Yannan Xi, Terrence F. Satterfield, Rebeca Choy, Tarunmeet Gujral, Eva Situ, Samnang Tep, Vivian Morton, Cecile Yu, Daniel Reiton, Baiwei Lin, Hanne Merritt, Pam Santiago, Bryan Espanol, Ryan A. Dick, Julie C. Ullman, Kevin T. Mellem, Sarah B. Noonberg, Eric M. Green, David J. Morgans, Sanjay J. Chandriani, David T. Beattie
Publikováno v:
Molecular Genetics and Metabolism. 135:S128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4db8190e8c179bb281f026c5840c76
https://doi.org/10.1016/j.ymgme.2021.11.342
https://doi.org/10.1016/j.ymgme.2021.11.342
Autor:
Julie C. Ullman, Kevin T. Mellem, Yannan Xi, Terrence F. Satterfield, Tarunmeet Gujral, Rebeca Choy, Julian R. Homburger, Hanne Merritt, Daniel Reiton, Samnang Tep, Baiwei Lin, Cecile Yu, Eva Situ, Walter Won, Hannah Powers, Vyas Ramanan, Maarten Hoek, Robert Graham, Sanjay J. Chandriani, Christopher Sinz, Ryan A. Dick, Sarah B. Noonberg, David T. Beattie, David J. Morgans, null Jr, Eric M. Green
Publikováno v:
Molecular Genetics and Metabolism. 135:S122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73295a112c6a5b30a62e86fb4a82cf5b
https://doi.org/10.1016/j.ymgme.2021.11.324
https://doi.org/10.1016/j.ymgme.2021.11.324
Autor:
A Kennedy, Aaron C. Hinken, William F. Browne, Kwan Leung, Matthew Tomlinson, Bradley P Morgan, James J. Hartman, Pu-Ping Lu, Gustave Bergnes, Fady I. Malik, David J. Morgans, Alexander Muci, David Marquez, Marc Garard, Ion Suehiro, Scott Collibee, Kenneth Lee, Donghong Xu, Alan J. Russell, Julia Schaletzky, Raja Kawas, Darren Hwee
Publikováno v:
ACS Medicinal Chemistry Letters
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1cd746965443b1eee2a4f71ea7923b
http://europepmc.org/articles/PMC5900333
http://europepmc.org/articles/PMC5900333
Autor:
James J. Hartman, David Ernest Clarke, Hector P. Rodriguez, Richard Hansen, Fady I. Malik, Bradley P. Morgan, Daniel L. Albertus, Michael M. Chen, Raja Kawas, William F. Browne, Khalil G. Saikali, Vipin Vijayakumar, David Marquez, Aaron C. Hinken, Alexander Muci, Scott Collibee, Alan J. Russell, Julia Schaletzky, Pu Ping Lu, Kenneth Lee, Marc Garard, David J. Morgans, Guillermo Godinez, Lena Driscoll, Zhiheng Jia, Dennis R. Claflin
Publikováno v:
Nature Medicine. 18:452-455
Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a15c06980cff853cda6d8b7c025847
https://doi.org/10.1038/nm.2618
https://doi.org/10.1038/nm.2618
Autor:
Malar Pannirselvam, Stephen F. Vatner, Xin Zhao, Sunil Dhar, David Ho, Xi Wang, Zhiheng Jia, Fady I. Malik, David J. Morgans, Patricio Abarzúa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 339:307-312
We examined a novel therapeutic approach for hypertension, a small-molecule direct inhibitor of smooth muscle myosin, CK-2018448 (CK-448), which is an N,N'-alkylurea (U.S. Patent Publication 2009-0275537 A1) in conscious dogs with renal hypertension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9cfd84f545a6ed5196d06789dd2846
https://doi.org/10.1124/jpet.111.182402
https://doi.org/10.1124/jpet.111.182402