Zobrazeno 1 - 10
of 715
pro vyhledávání: '"David J Mooney"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010240 (2022)
Staphylococcus aureus bacteremia (SAB) remains a clinically challenging infection despite extensive investigation. Repurposing medications approved for other indications is appealing as clinical safety profiles have already been established. Ticagrel
Externí odkaz:
https://doaj.org/article/59eac2d7c78f4f67b1ba271c52323c5e
Autor:
Pascal Joly, Thomas Schaus, Andrea Sass, Anke Dienelt, Alexander S Cheung, Georg N Duda, David J Mooney
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180568 (2017)
The use of autologous cells harvested and subsequently transplanted in an intraoperative environment constitutes a new approach to promote regeneration. Usually cells are isolated by selection methods such as fluorescence- or magnetic- activated cell
Externí odkaz:
https://doaj.org/article/7f187ea0db054a3f853dbae8a20f41fa
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124948 (2015)
Embryonic skeletogenesis involves proliferation, condensation and subsequent chondrogenic differentiation of mesenchymal precursor cells, and the strains and stresses inherent to these processes have been hypothesized to influence skeletal developmen
Externí odkaz:
https://doaj.org/article/f9d3722dbb744934bfd150c1140632a3
Autor:
Yulia Shamis, Eduardo A Silva, Kyle J Hewitt, Yevgeny Brudno, Shulamit Levenberg, David J Mooney, Jonathan A Garlick
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83755 (2013)
Human embryonic and induced pluripotent stem cells (hESC/hiPSC) are promising cell sources for the derivation of large numbers of specific cell types for tissue engineering and cell therapy applications. We have describe a directed differentiation pr
Externí odkaz:
https://doaj.org/article/41cb058ece594802a035388e51b3d038
Autor:
Andrew Cho, Naoto Haruyama, Bradford Hall, Mary Jo S Danton, Lu Zhang, Praveen Arany, David J Mooney, Yassine Harichane, Michel Goldberg, Carolyn W Gibson, Ashok B Kulkarni
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82267 (2013)
Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integ
Externí odkaz:
https://doaj.org/article/edabe76ea8724bed95ede251fffd2b00
Autor:
Kwasi Adu-Berchie, Joshua M. Brockman, Yutong Liu, Tania W. To, David K. Y. Zhang, Alexander J. Najibi, Yoav Binenbaum, Alexander Stafford, Nikolaos Dimitrakakis, Miguel C. Sobral, Maxence O. Dellacherie, David J. Mooney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Although adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a h
Externí odkaz:
https://doaj.org/article/c82858dc6c3249e0bed06dcad9fd4919
Autor:
Nuria Lafuente-Gómez, Irene de Lázaro, Mónica Dhanjani, David García-Soriano, Miguel C. Sobral, Gorka Salas, David J. Mooney, Álvaro Somoza
Publikováno v:
Materials Today Bio, Vol 23, Iss , Pp 100817- (2023)
Immunotherapy has emerged as a promising strategy to eradicate cancer cells. Particularly, the development of cancer vaccines to induce a potent and sustained antigen-specific T cell response has become a center of attention. Herein, we describe a no
Externí odkaz:
https://doaj.org/article/58b1cab7cdf242c4bff8ae3f5be0c307
Autor:
David K. Y. Zhang, Kwasi Adu-Berchie, Siddharth Iyer, Yutong Liu, Nicoletta Cieri, Joshua M. Brockman, Donna Neuberg, Catherine J. Wu, David J. Mooney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
‘Manufacturing CAR-T cells is a streamlined and highly regulated procedure involving T-cell-expansion and activation on a standardised platform. Here, the authors show that a personalized approach, taking the phenotypic attributes of individual pat
Externí odkaz:
https://doaj.org/article/f7959b99a7e04e99918762da2d538fbb
Autor:
David T. Wu, Mani Diba, Stephanie Yang, Benjamin R. Freedman, Alberto Elosegui‐Artola, David J. Mooney
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Multicellular spheroids made of stem cells can act as building blocks that fuse to capture complex aspects of native in vivo environments, but the effect of hydrogel viscoelasticity on cell migration from spheroids and their fusion remains l
Externí odkaz:
https://doaj.org/article/86c142d3d71a489492cc0e9b3d292f96
Autor:
Matthew D. Kerr, David A. McBride, Wade T. Johnson, Arun K. Chumber, Alexander J. Najibi, Bo Ri Seo, Alexander G. Stafford, David T. Scadden, David J. Mooney, Nisarg J. Shah
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Neutrophils are essential effector cells for mediating rapid host defense and their insufficiency arising from therapy‐induced side‐effects, termed neutropenia, can lead to immunodeficiency‐associated complications. In autologous hemat
Externí odkaz:
https://doaj.org/article/e291967d88574f02ad306dcef7787a12