Zobrazeno 1 - 10
of 93
pro vyhledávání: '"David J Merkler"'
Autor:
Adam A Aboalroub, Ashleigh B Bachman, Ziming Zhang, Dimitra Keramisanou, David J Merkler, Ioannis Gelis
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177270 (2017)
The transfer of an acetyl group from acetyl-CoA to an acceptor amine is a ubiquitous biochemical transformation catalyzed by Gcn5-related N-acetyltransferases (GNATs). Although it is established that the reaction proceeds through a sequential ordered
Externí odkaz:
https://doaj.org/article/ae15601347b4436b93c0145d219e22bc
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115644 (2015)
Proteomics is a powerful approach used for investigating the complex molecular mechanisms of disease pathogenesis and progression. An important challenge in modern protein profiling approaches involves targeting of specific protein activities in orde
Externí odkaz:
https://doaj.org/article/b716e41499534497bf32e89b7dfbff51
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Externí odkaz:
https://doaj.org/article/38c86db7c9784488bb5e593c584ba42e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
The fatty acid amides are a family of lipids composed of two chemical moieties, a fatty acid and a biogenic amine linked together in an amide bond. This lipid family is structurally related to the endocannabinoid anandamide (N-arachidonoylethanolamin
Externí odkaz:
https://doaj.org/article/1665a4b2ccf64f3692a0f51aa037d553
Publikováno v:
Journal of Biomedical Research & Environmental Sciences. 4:363-371
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Imaging (MALDI-MSI) has developed as a useful tool in generating comprehensive metabolite profiles along with spatial information in model organisms. The ability of MALDI-MSI to generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e82fdf181fec95b1f6fa30e15bda463
https://doi.org/10.37871/jbres1684
https://doi.org/10.37871/jbres1684
Autor:
Daniel R. Dempsey, Derek A. Nichols, Matthew R. Battistini, Orville Pemberton, Santiago Rodriguez Ospina, Xiujun Zhang, Anne-Marie Carpenter, Brian G. O’Flynn, James W. Leahy, Ankush Kanwar, Eric M. Lewandowski, Yu Chen, David J. Merkler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an or
Externí odkaz:
https://doaj.org/article/b2083b0e3aaf4cd49387f1ef030550cb
Autor:
Ruidong Ni, Suzeeta Bhandari, Perry R. Mitchell, Gabriela Suarez, Neel B. Patel, Kara Lamb, Kirpal S. Bisht, David J. Merkler
Publikováno v:
Molecules, Vol 26, Iss 9, p 2543 (2021)
Fatty acid amides are a diverse family of underappreciated, biologically occurring lipids. Herein, the methods for the chemical synthesis and subsequent characterization of specific members of the fatty acid amide family are described. The synthetica
Externí odkaz:
https://doaj.org/article/4df3576c4e614154bdbb2152862cb5a0
Autor:
Kristen A. Jeffries, Daniel R. Dempsey, Emma K. Farrell, Ryan L. Anderson, Gabrielle J. Garbade, Tatyana S. Gurina, Imran Gruhonjic, Carly A. Gunderson, David J. Merkler
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 5, Pp 781-790 (2016)
Long-chain fatty acid amides are signaling lipids found in mammals and other organisms; however, details of the metabolic pathways for the N-acylglycines and primary fatty acid amides (PFAMs) have remained elusive. Heavy-labeled precursor and subtrac
Externí odkaz:
https://doaj.org/article/f14b6dd5739e48668063e7ea222b40e8
Publikováno v:
British Journal of Pharmacology. 179:3306-3324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bb0bfd959bfb25f64a5e4e932a9118
https://doi.org/10.1111/bph.15815
https://doi.org/10.1111/bph.15815
Publikováno v:
Regulation of Downstream Targets ISBN: 9780443131813
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd9d6aa8cd6ba0f3babb19f1b7feaec8
https://doi.org/10.1016/bs.apcsb.2022.11.002
https://doi.org/10.1016/bs.apcsb.2022.11.002
