Zobrazeno 1 - 10
of 522
pro vyhledávání: '"David J McConkey"'
Autor:
Niannian Ji, Neelam Mukherjee, Tyler J Curiel, Ryan M Reyes, Jonathan Gelfond, Martin Javors, Joshua J. Meeks, David J McConkey, Zhen-Ju Shu, Chethan Ramamurthy, Ryan Dennett, Robert S Svatek
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Although intravesical BCG is the standard treatment of high-grade non-muscle invasive bladder cancer (NMIBC), response rates remain unsatisfactory. In preclinical models, rapamycin enhances BCG vaccine efficacy against tuberculosis and the
Externí odkaz:
https://doaj.org/article/8727334813974223b8ab1c8584e1818e
Autor:
Sakina A. Plumber, Tiffany Tate, Hikmat Al-Ahmadie, Xiao Chen, Woonyoung Choi, Merve Basar, Chao Lu, Aaron Viny, Ekatherina Batourina, Jiaqi Li, Kristjan Gretarsson, Besmira Alija, Andrei Molotkov, Gregory Wiessner, Byron Hing Lung Lee, James McKiernan, David J. McConkey, Colin Dinney, Bogdan Czerniak, Cathy Lee Mendelsohn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable expression in BASQ tumors, we tested the effects of rosiglitazone, Pparg agonist
Externí odkaz:
https://doaj.org/article/b207c60d5dd745fc8156b8526ea95f19
Autor:
Wei Qi, Matthew C White, Woonyoung Choi, Charles Guo, Colin Dinney, David J McConkey, Arlene Siefker-Radtke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69509 (2013)
The proteasome inhibitor bortezomib (Velcade) is a promising new agent for bladder cancer therapy, but inducible cytoprotective mechanisms may limit its potential efficacy. We used whole genome mRNA expression profiling to study the effects of bortez
Externí odkaz:
https://doaj.org/article/99e386bf5e4d456287cad0ee6b99a0d2
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57284 (2013)
Fibroblast growth factor receptors (FGFRs) are activated by mutation and overexpressed in bladder cancers (BCs), and FGFR inhibitors are currently being evaluated in clinical trials in BC patients. However, BC cells display marked heterogeneity in th
Externí odkaz:
https://doaj.org/article/d14498d357694471a910ddac86d2ebf5
Autor:
Woonyoung Choi, Jay B Shah, Mai Tran, Robert Svatek, Lauren Marquis, I-Ling Lee, Dasom Yu, Liana Adam, Sijin Wen, Yu Shen, Colin Dinney, David J McConkey, Arlene Siefker-Radtke
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30206 (2012)
p63 is a member of the p53 family that has been implicated in maintenance of epithelial stem cell compartments. Previous studies demonstrated that p63 is downregulated in muscle-invasive bladder cancers, but the relationship between p63 expression an
Externí odkaz:
https://doaj.org/article/a788a84875854ccb8726896a82333bdf
Autor:
Michael P Kim, Jason B Fleming, Huamin Wang, James L Abbruzzese, Woonyoung Choi, Scott Kopetz, David J McConkey, Douglas B Evans, Gary E Gallick
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20636 (2011)
Multiple studies in recent years have identified highly tumorigenic populations of cells that drive tumor formation. These cancer stem cells (CSCs), or tumor-initiating cells (TICs), exhibit properties of normal stem cells and are associated with res
Externí odkaz:
https://doaj.org/article/c0865d8e551044e2aa924de80e82b11c
Autor:
Noah M. Hahn, Michael A. O'Donnell, Jason A. Efstathiou, Marianna Zahurak, Gary L. Rosner, Jeff Smith, Max R. Kates, Trinity J. Bivalacqua, Phuoc T. Tran, Daniel Y. Song, Alex S. Baras, Andres Matoso, Woonyoung Choi, Kellie N. Smith, Drew M. Pardoll, Luigi Marchionni, Bridget McGuire, Mary Grace Phelan, Burles A. Johnson, Tanya O'Neal, David J. McConkey, Tracy L. Rose, Marc Bjurlin, Emerson A. Lim, Charles G. Drake, James M. McKiernan, Israel Deutsch, Christopher B. Anderson, Donald L. Lamm, Daniel M. Geynisman, Elizabeth R. Plimack, Mark A. Hallman, Eric M. Horwitz, Essel Al-Saleem, David Y.T. Chen, Richard E. Greenberg, Alexander Kutikov, Gordon Guo, Timothy A. Masterson, Nabil Adra, Hristos Z. Kaimakliotis
Publikováno v:
European Urology. 83:486-494
Autor:
Vamsi Parimi, Woonyoung Choi, Mingxiao Feng, Megan Fong, Jean Hoffman‐Censits, Max Kates, Kara A. Lombardo, Eva Comperat, David J. McConkey, Noah M. Hahn, Rodrigo Salgado Esteves, Andres Matoso
Publikováno v:
Histopathology. 82:991-1002
Autor:
Sharada Mokkapati, Vikram M. Narayan, Ganiraju C. Manyam, Amy H. Lim, Jonathan J. Duplisea, Andrea Kokorovic, Tanner S. Miest, Anirban P. Mitra, Devin Plote, Selvalakshmi Selvaraj Anand, Michael J. Metcalfe, Kenneth Dunner, Burles A. Johnson, Bogdan A. Czerniak, Tiina Nieminen, Tommi Heikura, Seppo Yla-Herttuala, Nigel R. Parker, Kimberley S. Schluns, David J. McConkey, Colin P. Dinney
Publikováno v:
Molecular Therapy - Oncolytics. 26:141-157
Interferon alpha (IFNα) gene therapy is emerging as a new treatment option for patients with non-muscle invasive bladder cancer (NMIBC). Adenoviral vectors expressing IFNα have shown clinical efficacy treating bacillus Calmette-Guerin (BCG)-unrespo
Autor:
Vamsi Parimi, Woonyoung Choi, Mingxiao Feng, Megan Fong, Jean Hoffman‐Censits, Max Kates, Kara A. Lombardo, Eva Comperat, David J. McConkey, Noah M. Hahn, Rodrigo Salgado Esteves, Andres Matoso
Publikováno v:
Histopathology. 82