Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David J Lowes"'
Autor:
Junyan Liu, Hubertine M E Willems, Emily A Sansevere, Stefanie Allert, Katherine S Barker, David J Lowes, Andrew C Dixson, Zhenbo Xu, Jian Miao, Christian DeJarnette, Helene Tournu, Glen E Palmer, Jonathan P Richardson, Francisco N Barrera, Bernhard Hube, Julian R Naglik, Brian M Peters
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009884 (2021)
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, play
Externí odkaz:
https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64
Autor:
Ana Camila Oliveira Souza, Adela Martin-Vicente, Ashley V Nywening, Wenbo Ge, David J Lowes, Brian M Peters, Jarrod R Fortwendel
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009806 (2021)
Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the echinocandin class of antifungals for invasive aspergillosis (IA) is limited. Recent studies suggest intense kinase- and phosphatase-mediated echinocandin a
Externí odkaz:
https://doaj.org/article/45cdacc750fa497a9c37634d2cb0fea0
Autor:
Junyan Liu, Amanda K. Vogel, Jian Miao, Jennifer A. Carnahan, David J. Lowes, Jeffrey M. Rybak, Brian M. Peters
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT As increasing evidence emerges that interstrain genetic diversity among Candida albicans clinical isolates underpins phenotypic variation compared to the reference isolate SC5314, new genetic tools are required to interrogate gene function a
Externí odkaz:
https://doaj.org/article/fadc0234ced749d7b7812a4bc018db12
Autor:
Kirk E. Hevener, Brian M. Peters, Kristiana A Avad, Jian Miao, Rand A Al-Waqfi, David J. Lowes
Publikováno v:
ACS Infectious Diseases. 7:2522-2535
Invasive and superficial infections caused by the Candida species result in significant global morbidity and mortality. As the pathogenicity of these organisms is intimately intertwined with host immune response, therapies to target both the fungus a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568afd701532128a839a6c0700f324b
https://doi.org/10.1021/acsinfecdis.1c00270
https://doi.org/10.1021/acsinfecdis.1c00270
Autor:
Hubertine M. E. Willems, Andrew C. Dixson, Glen E. Palmer, Junyan Liu, Stefanie Allert, Francisco N. Barrera, Brian M. Peters, Helene Tournu, Jonathan P. Richardson, Jian Miao, Christian DeJarnette, Bernhard Hube, David J. Lowes, Katherine S. Barker, Zhenbo Xu, Julian R. Naglik, Emily A. Sansevere
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009884 (2021)
PLoS Pathogens
PLoS Pathogens
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5540c6efd61dc51cb2045f29d6cd489e
https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64
https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64
Publikováno v:
Antimicrob Agents Chemother
Repurposing of currently approved medications is an attractive option for the development of novel treatment strategies against physiological and infectious diseases. The antidiabetic sulfonylurea glyburide has demonstrated off-target capacity to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e697551d3860e858285e68dac461ad95
https://pubmed.ncbi.nlm.nih.gov/31712208
https://pubmed.ncbi.nlm.nih.gov/31712208
Autor:
Brian M. Peters, Hubertine M. E. Willems, Glen E. Palmer, Katherine S. Barker, David J. Lowes
The human fungal pathogen Candida albicans is the major etiological agent of vulvovaginal candidiasis (VVC). Despite this fact, other non-albicans Candida (NAC) species have frequently been reported, as well. Despite their presence in the vaginal env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba485895e8fd090f8e8230800253f76
https://europepmc.org/articles/PMC6246903/
https://europepmc.org/articles/PMC6246903/
Autor:
Andrew Lemoff, Michele Connelly, David J. Lowes, Joseph L. DeRisi, Fangyi Zhu, W. Armand Guiguemde, R. Kiplin Guy, Martina Sigal, Julie Clark, Emily Wilson
Publikováno v:
Journal of Medicinal Chemistry. 54:7477-7485
Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug's potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0e0b4dfebd42fbf8f4054cff010759
https://doi.org/10.1021/jm2005546
https://doi.org/10.1021/jm2005546
Publikováno v:
Tetrahedron. 62:5099-5108
The synthesis of 6,6-difluoroshikimic acid (11) has been achieved in ten steps from the enantiopure diol 16, which is derived from enzymatic cis-dihydroxylation of iodobenzene. The versatility of the synthetic strategy has been demonstrated by the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04eab7852174a80c1a2239dfcd81e0cd
https://doi.org/10.1016/j.tet.2006.03.029
https://doi.org/10.1016/j.tet.2006.03.029
Autor:
Lovely Begum, Helen L. Whitby, Roger C. Whitehead, Jane L. Humphreys, Michael G. B. Drew, Pamela R. Russi, David J. Lowes
Publikováno v:
Tetrahedron Letters. 45:6249-6253
Exploitation of the dual dehydrating and fluorodeoxygenating properties of the dialkylaminosulfurtrifluorides has allowed access to the C3-fluorinated analogues of (−)-shikimic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9728fc82d8bf9bc8d3b45e8f5918d993
https://doi.org/10.1016/j.tetlet.2004.06.092
https://doi.org/10.1016/j.tetlet.2004.06.092