Zobrazeno 1 - 10
of 108
pro vyhledávání: '"David J Lamb"'
Autor:
Julia A Gindele, Samuel Mang, Nicolas Pairet, Ingrid Christ, Florian Gantner, Jürgen Schymeinsky, David J Lamb
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184386 (2017)
Inappropriate repair responses to pulmonary epithelial injury have been linked to perturbation of epithelial barrier function and airway remodelling in a number of respiratory diseases, including chronic obstructive pulmonary disease and idiopathic p
Externí odkaz:
https://doaj.org/article/ab5ee77dde8547e59d8d3bedb8d54a8f
Autor:
Reinoud Gosens, Janette K. Burgess, Rosa K. Kortekaas, Megan J. Webster, Roël van Orsoy, David J. Lamb
Publikováno v:
Trends in Pharmacological Sciences. 42(5):354-366
Interleukin (IL)-11 was originally recognized as an immunomodulatory and hematopoiesis-inducing cytokine. However, although IL-11 is typically not found in healthy individuals, it is now becoming evident that IL-11 may play a role in diverse pulmonar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200038bd3e2918af5e349f4a27bfaf61
https://hdl.handle.net/11370/896d0c9e-6322-4c96-bcd1-62f89730c642
https://hdl.handle.net/11370/896d0c9e-6322-4c96-bcd1-62f89730c642
Autor:
Nathalie Harrer, Annika Osswald, Andreas Wernitznig, Ingrid Christ, Albin Rudisch, Aleksander Rust, David J. Lamb, Herwig Machat, Wolfgang Sommergruber, Florian Colbatzky, Tobias Glüxam
Publikováno v:
Oncotarget
SYK has been reported to possess both tumour promotor and repressor activities and deletion has been linked to a pro-proliferative / pro-invasive phenotype in breast tumours. It is unclear whether this is a consequence of protein deletion or loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a402869c39282cf28e4bf450002a0
https://doi.org/10.18632/oncotarget.27545
https://doi.org/10.18632/oncotarget.27545
Publikováno v:
Allergy and immunology.
Introduction: Cough is a debilitating symptom with a significant impact on quality of life. Patients with refractory chronic cough typically cough hundreds of times per day therefore we hypothesised that the associated pressures and shearing forces m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e86d359d440f4c2a0c768765bf8a47d
https://doi.org/10.1183/13993003.congress-2021.pa3112
https://doi.org/10.1183/13993003.congress-2021.pa3112
Autor:
Alexandre Rosa Campos, Coralie Viollet, Ines Kollak, Martina Keck, Karsten Quast, Dagmar Knebel, Victoria Schroeder, James P. Garnett, Huy Quang Le, Jun Li, Benjamin Strobel, Franziska Herrmann, David J. Lamb, M.J. Thomas, Johannes Wirth, Heiko Stahl, Wioletta Skronska-Wasek, Eva Schruf, Matthew A Hill
Publikováno v:
EMBO Reports
Unveiling the molecular mechanisms of tissue remodelling following injury is imperative to elucidate its regenerative capacity and aberrant repair in disease. Using different omics approaches, we identified enhancer of zester homolog 2 (EZH2) as a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30b077b28f61120a5c3812acdc2da51
https://www.repository.cam.ac.uk/handle/1810/331261
https://www.repository.cam.ac.uk/handle/1810/331261
Autor:
K.E. Geillinger-Kaestle, M.J. Thomas, Griesser E, Birgit Stierstorfer, David J. Lamb, Thorsten Lamla, Schoenberger T, Wyatt H, Wolfgang Rist
Background & aimRecurring epithelial injury and aberrant repair are considered as a major driver of idiopathic pulmonary fibrosis (IPF) leading to chronic inflammation, fibroblast activation and ultimately to scarring and stiffening of the lung. As d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313772ece248194c6708d5bbe5d76892
https://doi.org/10.1101/2021.06.18.445859
https://doi.org/10.1101/2021.06.18.445859
Autor:
Sebastian Schafer, Anissa A. Widjaja, Jinrui Dong, Shamini Guna Shekeran, Brijesh K. Singh, Stuart A. Cook, Goh Jwt, Tan J, Benjamin L. George, Carling D, David J. Lamb, Sivakumar Viswanathan, Eleonora Adami
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signalling pathways downstream of IL11 are contentious and both STAT3 and ERK have been implicated. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc9b4553c17f3df386eff3943a5128b
https://doi.org/10.1101/2021.06.10.447846
https://doi.org/10.1101/2021.06.10.447846
Autor:
Mariska P. M. van den Berg, Susan Nijboer-Brinksma, Martijn van Faassen, Maarten van den Berge, David J. Lamb, Ido P. Kema, Reinoud Gosens, I. Sophie T. Bos, Loes E. M. Kistemaker
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Respiratory Research
Respiratory Research, 22(1):48. BioMed Central Ltd.
Respiratory Research
Respiratory Research, 22(1):48. BioMed Central Ltd.
Background Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to asthma characteristics including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a946ee64706f3f8dba2fb772d54d44a
https://doi.org/10.21203/rs.3.rs-88800/v1
https://doi.org/10.21203/rs.3.rs-88800/v1
Publikováno v:
Airway pharmacology and treatment.
Background: Spleen tyrosine kinase (SYK) inhibitors have therapeutic potential for severe asthma. In rats, activity of SYK inhibitor BI 1002494 measured with a CD63 assay correlated well with bronchoconstriction and airway resistance (Lamb DJ, et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f7d1a99a49baf341d96949b47703c3
https://doi.org/10.1183/13993003.congress-2020.3301
https://doi.org/10.1183/13993003.congress-2020.3301
Autor:
K.E. Geillinger-Kaestle, A. Schoenleber, A. Maier, Martina Keck, S. Blum, Thorsten Lamla, H. Lichius, M. Schilling, Sorif Uddin, David J. Lamb, M.J. Thomas
Publikováno v:
D27. CELLULAR RESPONSES INFORMING LUNG REPAIR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eaf7d070b273257588850e62665c886
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6404
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6404