Zobrazeno 1 - 10
of 47
pro vyhledávání: '"David J Jörg"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010850 (2023)
Patients with renal anemia are frequently treated with erythropoiesis-stimulating agents (ESAs), which are dynamically dosed in order to stabilize blood hemoglobin levels within a specified target range. During typical ESA treatments, a fraction of p
Externí odkaz:
https://doaj.org/article/ccb441708a584dfbbe2497350d0b8f40
Autor:
David J Jörg, Doris H Fuertinger, Alhaji Cherif, David A Bushinsky, Ariella Mermelstein, Jochen G Raimann, Peter Kotanko
Publikováno v:
eLife, Vol 11 (2022)
For the treatment of postmenopausal osteoporosis, several drug classes with different mechanisms of action are available. Since only a limited set of dosing regimens and drug combinations can be tested in clinical trials, it is currently unclear whet
Externí odkaz:
https://doaj.org/article/cfa893961c024e1bb8eb730ff02f4a99
Autor:
David J Jörg, Elizabeth E Caygill, Anna E Hakes, Esteban G Contreras, Andrea H Brand, Benjamin D Simons
Publikováno v:
eLife, Vol 8 (2019)
In living organisms, self-organised waves of signalling activity propagate spatiotemporal information within tissues. During the development of the largest component of the visual processing centre of the Drosophila brain, a travelling wave of proneu
Externí odkaz:
https://doaj.org/article/5522429ebf6349598cf5ed0127e55101
Autor:
Lucas Wetzel, David J Jörg, Alexandros Pollakis, Wolfgang Rave, Gerhard Fettweis, Frank Jülicher
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171590 (2017)
Self-organized synchronization occurs in a variety of natural and technical systems but has so far only attracted limited attention as an engineering principle. In distributed electronic systems, such as antenna arrays and multi-core processors, a co
Externí odkaz:
https://doaj.org/article/524818f3c87340aa97a6d58e2d1530ef
Autor:
Alexis B Webb, Iván M Lengyel, David J Jörg, Guillaume Valentin, Frank Jülicher, Luis G Morelli, Andrew C Oates
Publikováno v:
eLife, Vol 5 (2016)
In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a “segmentation clock”. This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression p
Externí odkaz:
https://doaj.org/article/29730dd0e20b49f9ac4bd7bf3bf6e6b6
Publikováno v:
New Journal of Physics, Vol 17, Iss 9, p 093042 (2015)
The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here
Externí odkaz:
https://doaj.org/article/670a4c73309d4f7a96f1b30781763b47
Autor:
Alexandros Pollakis, Lucas Wetzel, David J Jörg, Wolfgang Rave, Gerhard Fettweis, Frank Jülicher
Publikováno v:
New Journal of Physics, Vol 16, Iss 11, p 113009 (2014)
Electronic components that perform tasks in a concerted way rely on a common time reference. For instance, parallel computing demands synchronous clocking of multiple cores or processors to reliably carry out joint computations. Here, we show that mu
Externí odkaz:
https://doaj.org/article/11dbbede4b8a43d988be30a38d8ff9a3
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 7, Pp 436-440 (2022)
Abstract Erythropoietin deficiency is an extensively researched cause of renal anemia. The etiology and consequences of shortened red blood cell (RBC) life span in chronic kidney disease (CKD) are less well understood. Traversing capillaries requires
Externí odkaz:
https://doaj.org/article/4b877a9ec8904130a7a078a30c06124c
Autor:
Toshinori Nakagawa, David J. Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D. Simons, Shosei Yoshida, Takashi Nagasawa
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109875- (2021)
Summary: In mouse testis, a heterogeneous population of undifferentiated spermatogonia (Aundiff) harbors spermatogenic stem cell (SSC) potential. Although GFRα1+ Aundiff maintains the self-renewing pool in homeostasis, the functional basis of hetero
Externí odkaz:
https://doaj.org/article/65978c133f0e40fea4fb9cba4e4d510d
Autor:
Gabriela Ferreira Dias, Nadja Grobe, Sabrina Rogg, David J. Jörg, Roberto Pecoits-Filho, Andréa Novais Moreno-Amaral, Peter Kotanko
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Red blood cells (RBC) are the most abundant cells in the blood. Despite powerful defense systems against chemical and mechanical stressors, their life span is limited to about 120 days in healthy humans and further shortened in patients with kidney f
Externí odkaz:
https://doaj.org/article/46a460344fa54812a04155b49ce70a18