Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David J Huels"'
Autor:
Rana Ramadan, Valérie M. Wouters, Sanne M. van Neerven, Nina E. de Groot, Tania Martins Garcia, Vanessa Muncan, Olivia D. Franklin, Michelle Battle, Karen Sue Carlson, Joshua Leach, Owen J. Sansom, Olivier Boulard, Mathias Chamaillard, Louis Vermeulen, Jan Paul Medema, David J. Huels
Publikováno v:
Biology Open, Vol 11, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/ee689493b87c437690668170fbf2c3b2
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and infla
Externí odkaz:
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101050- (2022)
Summary: Intestinal organoid cultures are a powerful tool to study epithelial cells in vitro, as they are able to proliferate and differentiate into all cell lineages observed in vivo. Co-culturing organoids with distinct genetic backgrounds provides
Externí odkaz:
https://doaj.org/article/bdcc04b68bf648edb4770ee43649041c
Autor:
David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells
Externí odkaz:
https://doaj.org/article/c9f52c1c744446f184d2f16004401292
Autor:
Maria Azkanaz, Bernat Corominas-Murtra, Saskia I. J. Ellenbroek, Lotte Bruens, Anna T. Webb, Dimitrios Laskaris, Koen C. Oost, Simona J. A. Lafirenze, Karl Annusver, Hendrik A. Messal, Sharif Iqbal, Dustin J. Flanagan, David J. Huels, Felipe Rojas-Rodríguez, Miguel Vizoso, Maria Kasper, Owen J. Sansom, Hugo J. Snippert, Prisca Liberali, Benjamin D. Simons, Pekka Katajisto, Edouard Hannezo, Jacco van Rheenen
Publikováno v:
Nature, 607(7919), 548-554. Nature Publishing Group
Nature
Nature
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts(1-3). Whether stem cell numbers and behaviour vary at different sites is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056f78ddf82a288546d7d0c38e5f8447
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85134162879&partnerID=8YFLogxK
Autor:
Ester Gil Vazquez, Nadia Nasreddin, Gabriel N. Valbuena, Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Holly R. Eggington, Ryan O. Schenck, Valérie M. Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R.M. Lannagan, Dustin J. Flanagan, Arafath K. Najumudeen, Sulochana Omwenga, Amy M.B. McCorry, Alistair Easton, Viktor H. Koelzer, James E. East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D. Campbell, Maurice B. Loughrey, Philip D. Dunne, Petros Tsantoulis, David J. Huels, Sabine Tejpar, Owen J. Sansom, Simon J. Leedham
Publikováno v:
Vasquez, E G, Nasreddin, N, Valbuena, G N, Mulholland, E J, Belnoue-Davis, H L, Eggington, H R, Schenck, R O, Wouters, V M, Wirapati, P, Gilroy, K, Lannagan, T R M, Flanagan, D J, Najumudeen, A K, Omwenga, S, McCorry, A M B, Easton, A, Koelzer, V H, East, J E, Morton, D, Trusolino, L, Maughan, T, Loughrey, M B, Dunne, P D, Tsantoulis, P, Huels, D J, Tejpar, S, Sansom, O J & Leedham, S J 2022, ' Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia ', Cell Stem Cell, vol. 29, no. 8, pp. 1213-1228.e8 . https://doi.org/10.1016/j.stem.2022.07.008
Cell stem cell, 29(8), 1213-1228.e8. Cell Press
Cell stem cell, 29(8), 1213-1228.e8. Cell Press
Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterized by fetal transcriptional prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8ae6065d6af4d48e6bf14034d2918
https://pure.qub.ac.uk/en/publications/ebe1f6bb-dff1-49d2-b1ec-2dd3b998e338
https://pure.qub.ac.uk/en/publications/ebe1f6bb-dff1-49d2-b1ec-2dd3b998e338
Autor:
Ester Gil Vazquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valérie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham
Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterised by fetal transcriptional prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbefa25d12c76480d625ba52678c0be8
https://doi.org/10.1101/2022.06.11.495729
https://doi.org/10.1101/2022.06.11.495729
Autor:
Je-Hoon Song, David J. Huels, Rachel A. Ridgway, Owen J. Sansom, Boris N. Kholodenko, Walter Kolch, Kwang-Hyun Cho
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 94-103 (2014)
Self-renewal is essential for multicellular organisms but carries the risk of somatic mutations that can lead to cancer, which is particularly critical for rapidly renewing tissues in a highly mutagenic environment such as the intestinal epithelium.
Externí odkaz:
https://doaj.org/article/5eaeec55f16e4f828c8123215f222681
The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues
Autor:
Anna-Karin E. Johnsson, Yanfeng Dai, Max Nobis, Martin J. Baker, Ewan J. McGhee, Simon Walker, Juliane P. Schwarz, Shereen Kadir, Jennifer P. Morton, Kevin B. Myant, David J. Huels, Anne Segonds-Pichon, Owen J. Sansom, Kurt I. Anderson, Paul Timpson, Heidi C.E. Welch
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 1153-1164 (2014)
The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific cell morphologies and responses. Here, we have generated a mouse strain, Rac-FRET, which ub
Externí odkaz:
https://doaj.org/article/8bdba94a3f9d43c791b34b84ce9c7d0a
Autor:
David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained an error in the spelling of the author Miryam Müller, which was incorrectly given as Miryam Müeller. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/149f5d2663df4af8ad159e951484f816