Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David J Hele"'
Autor:
David J Hele, Maria G. Belvisi, V Freund-Michel, Hema J Patel, Mark A. Birrell, Natascia Crispino
Publikováno v:
British Journal of Pharmacology. 155:547-557
Background and purpose: Sensory nerves regulate central and local reflexes such as airway plasma protein leakage, bronchoconstriction and cough. Sensory nerve activity may be enhanced during inflammation such that these protective effects become exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a777fc3078cf237a3d3675e6875fcd
https://doi.org/10.1038/bjp.2008.298
https://doi.org/10.1038/bjp.2008.298
Autor:
Maria G. Belvisi, David J Hele
Publikováno v:
Drug Discovery Today: Disease Models. 3:237-241
Cough is often associated with inflammatory airway disease and is an unmet clinical need. To provide successful future therapies, good disease models are required. Citric acid has been used to provoke cough in humans and to induce cough in guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9e0e1d71c55c1fc0e53a73c351e096c
https://doi.org/10.1016/j.ddmod.2006.10.006
https://doi.org/10.1016/j.ddmod.2006.10.006
Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation
Publikováno v:
European Journal of Pharmacology. 533:101-109
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPARgamma regulates several metabolic pathways by binding to sequence-specific PPAR respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4880e6622d95817ed4e6f5c44e3310
https://doi.org/10.1016/j.ejphar.2005.12.048
https://doi.org/10.1016/j.ejphar.2005.12.048
Publikováno v:
Expert Opinion on Therapeutic Targets. 8:265-285
Asthma and chronic obstructive pulmonary disease (COPD) are diseases of the airways with an underlying inflammatory component. The prevalence and healthcare burden of asthma and COPD is still rising and is predicted to continue to rise in the foresee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87679f3b828182056433e5c5b5a9498
https://doi.org/10.1517/14728222.8.4.265
https://doi.org/10.1517/14728222.8.4.265
Autor:
Hema J Patel, Maria G. Belvisi, Mark A. Birrell, Magdi H. Yacoub, Priya Venkatesan, Natascia Crispino, David J Hele, Peter J. Barnes
Publikováno v:
British Journal of Pharmacology. 140:261-268
1. There is considerable interest in novel therapies for cough, since currently used agents such as codeine have limited beneficial value due to the associated side effects. Sensory nerves in the airways mediate the cough reflex via activation of C-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94f80269d1b259d094b7a1b70efbc5b
https://doi.org/10.1038/sj.bjp.0705435
https://doi.org/10.1038/sj.bjp.0705435
Autor:
David J Hele, Maria G. Belvisi
Publikováno v:
Expert Opinion on Investigational Drugs. 12:5-18
Asthma and chronic obstructive pulmonary disease (COPD) are diseases of the airways with an underlying inflammatory component. The prevalence and healthcare burden of asthma and COPD is still rising and is predicted to continue to rise in the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b628d5c50a69bae9e5e152e4b9c65dc
https://doi.org/10.1517/13543784.12.1.5
https://doi.org/10.1517/13543784.12.1.5
Autor:
Natascia Crispino, Hema J Patel, David J Hele, Peter J. Barnes, Maria G. Belvisi, Magdi H. Yacoub, Mark A. Birrell
Publikováno v:
British Journal of Pharmacology. 136:620-628
Sensory nerves regulate central and local reflexes such as airway plasma leakage, and cough and their function may be enhanced during inflammation. Evidence suggests that dopamine receptor agonists may inhibit sensory nerve-mediated responses. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5ed96443715a6d61e5d6d9d2bf8572
https://doi.org/10.1038/sj.bjp.0704758
https://doi.org/10.1038/sj.bjp.0704758
Autor:
David J Hele, Mark A. Birrell, Peter J. Barnes, Lucia Spicuzza, Mark A. Giembycz, Maria G. Belvisi
Publikováno v:
British Journal of Pharmacology. 133:1201-1212
The spasmolytic and anti-spasmogenic activity of β-adrenoceptor agonists on airways smooth muscle is thought to involve activation of the cyclic AMP/cyclic AMP-dependent protein kinase (PKA) cascade. Here we have tested the hypothesis that PKA media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf3ac7d0fc5e6ad743d380b7f360d76
https://doi.org/10.1038/sj.bjp.0704213
https://doi.org/10.1038/sj.bjp.0704213
Autor:
Nicola E. Wilsher, Andrew J. Ratcliffe, Brenda J. Burton, Collis Alan John, Maria G. Belvisi, Iain Mcfarlane Mclay, Chris Maslen, Simon Phipps, Martyn Foster, Kenneth Page, Michael F. Kelley, Bryan Slater, Stephen E Webber, Jayyosi Zaid, Kenneth Pollock, V. Benning, Alex Constan, Elisabeth J. Redford, David J Hele, Jeffrey Mckenna, Glen K. Miller, Véronique Thybaud, Barry Porter, Frank Halley, Marie-Claude Ouldelhkim, Mark A. Birrell, John E. Souness
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:537-554
RPR132331, a 2-(2-dioxanyl)imidazole, was identified as an inhibitor of tumour necrosis factor (TNF)alpha release from lipopolysaccharide (LPS)-stimulated human monocytes. An intensive programme of work exploring the biology, toxicity and physical ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1d3c32faee27bb16a4948e22eec577
https://doi.org/10.1016/s0968-0896(00)00331-x
https://doi.org/10.1016/s0968-0896(00)00331-x
Autor:
Sarah A. Maher, David J Hele, Laura R. Sadofsky, Shoaib Faruqi, Mark A. Birrell, Megan S. Grace, Véronique Freund-Michel, Alyn H. Morice, Maria G. Belvisi
Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is also increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002888ad9cdb2290ae263582d837b670
http://hdl.handle.net/10044/1/19321
http://hdl.handle.net/10044/1/19321
