Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David J Hawellek"'
Autor:
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials. Sensiti
Externí odkaz:
https://doaj.org/article/89b2e043ae1a4ef094cfbb9512ed2741
Autor:
Stephanie Vauleon, Katharina Schutz, Benoit Massonnet, Nanda Gruben, Marianne Manchester, Alessandra Buehler, Eginhard Schick, Lauren Boak, David J. Hawellek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Huntington’s disease (HD) is caused by a cytosine adenine guanine-repeat expansion in the huntingtin gene. This results in the production of toxic mutant huntingtin protein (mHTT), which has an elongated polyglutamine (polyQ) stretch near
Externí odkaz:
https://doaj.org/article/bad2f4a1d56e443989a5c40b6c57ac69
Speech, as the spoken form of language, is fundamental for human communication. The phenomenon of covert inner speech implies a functional independence of speech content and motor production. However, it remains unclear how a flexible mapping between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70c56cba18333b8e1b563a220c929fb8
https://doi.org/10.1101/2022.09.30.510259
https://doi.org/10.1101/2022.09.30.510259
Autor:
David J Hawellek, Denis A Engemann, Stefan Holiga, Antonio Napolitano, Maryam Abaei, Peter McColgan
Publikováno v:
E: Imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5bfa2abb56070cd79d7b0107c52ec8
https://doi.org/10.1136/jnnp-2022-ehdn.86
https://doi.org/10.1136/jnnp-2022-ehdn.86
Autor:
Scott Schobel, Lauren Boak, Nanda Gruben, Katharina Schutz, Stephanie Vauleon, Marianne Manchester, David J. Hawellek, Benoit Massonnet
Publikováno v:
D: Wet biomarkers.
Background Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin gene, resulting in the production of toxic mutant huntingtin protein (mHTT). Quantification of mHTT in the cerebrospinal fluid (CSF) of patients with HD usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2024172727a436f3d55be361de7a64
https://doi.org/10.1136/jnnp-2021-ehdn.32
https://doi.org/10.1136/jnnp-2021-ehdn.32
Synchronized neuronal population activity in the gamma-frequency range (> 30 Hz) correlates with the bottom-up drive of various visual features. It has been hypothesized that gamma-band synchronization enhances the gain of neuronal representations, y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb73a2240fce65b4d7a7f821761a9cc
https://doi.org/10.1101/741066
https://doi.org/10.1101/741066
SummaryEconomic decisions can adapt to contexts. Choices can be quick and impulsive or slow and more deliberative, depending on the temporal context. Choices can also depend on how we enact the choice, in an action context. Where we decide to go for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f6a4d646cd3ec75b5fe9b81af5fa69
https://doi.org/10.1101/445346
https://doi.org/10.1101/445346
Publikováno v:
ICCV Workshops
Facial expressions play a significant role in the expression of emotional states, such as fear, surprise, and happiness in humans and other animals. The current systems for recognizing animal facial expression model in Non-human primates (NHPs) are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627ce74691e8521ccd62e7d39643fdd4
https://doi.org/10.1109/iccvw.2017.332
https://doi.org/10.1109/iccvw.2017.332
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(47)
Making a decision involves computations across distributed cortical and subcortical networks. How such distributed processing is performed remains unclear. We test how the encoding of choice in a key decision-making node, the posterior parietal corte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52523991d92be30bd3f35e7443236154
https://pubmed.ncbi.nlm.nih.gov/27821752
https://pubmed.ncbi.nlm.nih.gov/27821752
Publikováno v:
Proceedings of the National Academy of Sciences
Correlations in spontaneous brain activity provide powerful access to large-scale organizational principles of the CNS. However, making inferences about cognitive processes requires a detailed understanding of the link between these couplings and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a432cae48a8a591e0e686f209141946
https://doi.org/10.1073/pnas.1110024108
https://doi.org/10.1073/pnas.1110024108