Zobrazeno 1 - 10
of 114
pro vyhledávání: '"David J Hardy"'
Autor:
Peter Wotherspoon, Hannah Johnston, David J. Hardy, Rachel Holyfield, Soi Bui, Giedrė Ratkevičiūtė, Pooja Sridhar, Jonathan Colburn, Charlotte B. Wilson, Adam Colyer, Benjamin F. Cooper, Jack A. Bryant, Gareth W. Hughes, Phillip J. Stansfeld, Julien R. C. Bergeron, Timothy J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The Maintenance of Lipid Asymmetry (Mla) pathway is a multicomponent system found in all gram-negative bacteria that contributes to virulence, vesicle blebbing and preservation of the outer membrane barrier function. It acts by removing ecto
Externí odkaz:
https://doaj.org/article/b7c3efd6199f407a8b00be9ac32695d5
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9, p e1000939 (2010)
Oseltamivir (Tamiflu) is currently the frontline antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase, a flu protein responsible for the release of newly synthesized virions. However, oseltamivir resistan
Externí odkaz:
https://doaj.org/article/5bfb3607c96b44eeabc7ae10f3fd593d
Autor:
Alberto Luis Fernández, Gabriel Jáuregui Arriondo, Maximiliano Folmer, Marcelo Vaiman, Gazul Rotela Leite, David J. Hardy
Publikováno v:
Culture and Brain. 10:167-193
Autor:
Anda Trifan, Defne Gorgun, Michael Salim, Zongyi Li, Alexander Brace, Maxim Zvyagin, Heng Ma, Austin Clyde, David Clark, David J Hardy, Tom Burnley, Lei Huang, John McCalpin, Murali Emani, Hyenseung Yoo, Junqi Yin, Aristeidis Tsaris, Vishal Subbiah, Tanveer Raza, Jessica Liu, Noah Trebesch, Geoffrey Wells, Venkatesh Mysore, Thomas Gibbs, James Phillips, S Chakra Chennubhotla, Ian Foster, Rick Stevens, Anima Anandkumar, Venkatram Vishwanath, John E Stone, Emad Tajkhorshid, Sarah A Harris, Arvind Ramanathan
Publikováno v:
The International Journal of High Performance Computing Applications. 36:603-623
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) replication transcription complex (RTC) is a multi-domain protein responsible for replicating and transcribing the viral mRNA inside a human cell. Attacking RTC function with pharmaceut
Autor:
David J. Hardy
Publikováno v:
Brain Sciences, Vol 11, Iss 5, p 647 (2021)
In a brief overview of neuroergonomics, including some personal reminiscences of Raja Parasuraman, it is recognized that the field of human factors and ergonomics has benefitted greatly from the inclusion and integration of neuroscientific methods an
Externí odkaz:
https://doaj.org/article/f04777aef5644ec58fe0ae8740978c1e
Autor:
Mohammad Soroush Barhaghi, Brad Crawford, Gregory Schwing, David J. Hardy, John E. Stone, Loren Schwiebert, Jeffrey Potoff, Emad Tajkhorshid
Publikováno v:
Journal of Chemical Theory and Computation. 18:4983-4994
py-MCMD, an open-source Python software, provides a robust workflow layer that manages communication of relevant system information between the simulation engines NAMD and GOMC and generates coherent thermodynamic properties and trajectories for anal
Autor:
Caitlin Hatton, Nadisha Gamage, Pooja Sridhar, Stephen C.L. Hall, Peter J. Wotherspoon, Gareth W. Hughes, Luke A. Clifton, James Whitehouse, Claire S. Laxton, Timothy J. Knowles, John Wright, Mark Jeeves, David J. Hardy
Publikováno v:
Biophys J
The outer membrane of Gram-negative bacteria presents a robust physicochemical barrier protecting the cell from both the natural environment and acting as the first line of defense against antimicrobial materials. The proteins situated within the out
Publikováno v:
Proc UrgentHPC 2021 (2021)
Over the past 18 months, the need to perform atomic detail molecular dynamics simulations of the SARS-CoV-2 virion, its spike protein, and other structures related to the viral infection cycle has led biomedical researchers worldwide to urgently seek
Autor:
David J. Hardy, Charles H. Hinkin
Publikováno v:
Frontiers in Neuroergonomics. 3
A preliminary set of analyses are presented, where workload was examined in 32 adults infected with the human immunodeficiency virus (HIV). Like the current COVID-19 pandemic (caused by the SARS-CoV-2 virus), HIV can produce a wide variety of symptom
Publikováno v:
Journal of the International Neuropsychological Society. 27:389-395
Objective:Incidental learning and memory, as well as processing speed, were examined in human immunodeficiency virus (HIV)-positive adults and a seronegative control group.Methods:Participants completed a computerized Symbol-Digit Modalities Test (cS