Simple models of quantitative firing phenotypes in hippocampal neurons: Comprehensive coverage of intrinsic diversity.

Autor: Siva Venkadesh, Alexander O Komendantov, Diek W Wheeler, David J Hamilton, Giorgio A Ascoli

Publikováno v: PLoS Computational Biology, Vol 15, Iss 10, p e1007462 (2019)

Patterns of periodic voltage spikes elicited by a neuron help define its dynamical identity. Experimentally recorded spike trains from various neurons show qualitatively distinguishable features such as delayed spiking, spiking with or without freque

Externí odkaz: https://doaj.org/article/33b684ee768a490eb92af4b80b70f1da

Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates.

Autor: Jessica A Harris, Koushik Roy, Virginia Woo-Rasberry, David J Hamilton, Rita Kansal, Firdausi Qadri, James M Fleckenstein

Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1428 (2011)

Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in developing countries, where it accounts for millions of infections and hundreds of thousands of deaths annually. While vaccine development to prevent diarrheal illness due to ET

Externí odkaz: https://doaj.org/article/d8880f8bd0734ea7bea539e95ec9c182

Methylsulfonylmethane and sesame seed oil improve hyperlipidemia and polyunsaturated fatty acid metabolism in the db/db mouse

Autor: Jonathan Chapman, Ling Lin, Charles R. Yates, David J. Hamilton, Cameron V. Fili

BackgroundAn estimated 463 million people worldwide suffer from diabetes, and that number is projected to rise significantly to 700 million by 2045. One of the hallmarks of type 2 diabetes and metabolic syndrome is alterations in the lipid profile an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7681d9a8501bc4045977d3703f18d5d7
https://doi.org/10.1101/2020.12.30.424717

Escape from planarity in fragment-based drug discovery:A physicochemical and 3D property analysis of synthetic 3D fragment libraries

Autor: Tom Dekker, Iwan J. P. de Esch, Peter O'Brien, Maikel Wijtmans, Guido V. Janssen, Hanna F. Klein, David J. Hamilton

Publikováno v: Hamilton, D J, Dekker, T, Klein, H F, Janssen, G V, Wijtmans, M, O'Brien, P & de Esch, I J P 2020, ' Escape from planarity in fragment-based drug discovery : A physicochemical and 3D property analysis of synthetic 3D fragment libraries ', Drug Discovery Today: Technologies, vol. 38, pp. 77-90 . https://doi.org/10.1016/j.ddtec.2021.05.001

Fragment-based drug discovery (FBDD) has grown into a well-established approach in the pursuit of new therapeutics. Key to the success of FBDD is the low molecular complexity of the initial hits and this has resulted in fragment libraries that mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc38603eadbf77a17dc56812e16b277
https://research.vu.nl/en/publications/f8c25374-2593-40bf-b7f3-9e524477564f

Bromo-Cyclobutenaminones as New Covalent UDP

Autor: David J, Hamilton, Péter, Ábrányi-Balogh, Aaron, Keeley, László, Petri, Martina, Hrast, Tímea, Imre, Maikel, Wijtmans, Stanislav, Gobec, Iwan J P de, Esch, György Miklós, Keserű

Publikováno v: Pharmaceuticals

Drug discovery programs against the antibacterial target UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. In the current study, the reactivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23091aab9b036fa5a5d02bfceb5ca0d0
https://pubmed.ncbi.nlm.nih.gov/33153141