Zobrazeno 1 - 10
of 86
pro vyhledávání: '"David J Grainger"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008460 (2020)
Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to different conditions? Here, we explore a biophysical cost-benefit principle, namely that the cell s
Externí odkaz:
https://doaj.org/article/bbede27205254f31bdfbbb913921e922
Autor:
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17152 (2011)
GABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs. Recent work has shown that Cys-loop receptors are pr
Externí odkaz:
https://doaj.org/article/23173b15fc8b4b9690a691153a3c3a03
A series of 3-acylaminocaprolactams are inhibitors of chemokine-induced chemotaxis. Branching of the side chain alpha-carbon provides highly potent inhibitors of a range of CC and CXC chemokines. The most potent compound has an ED(50) of 40 pM. Selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f3b22c06f765c80cc93f57a539daa4
https://ora.ox.ac.uk/objects/uuid:817ddac0-7e75-4b21-aaae-64d29e2fe93d
https://ora.ox.ac.uk/objects/uuid:817ddac0-7e75-4b21-aaae-64d29e2fe93d
Autor:
Gemma L. Bourne, David J. Grainger
Publikováno v:
Journal of Immunological Methods. 364:101-108
Furin is a serine endoprotease that is responsible for the proteolytic processing of proteins within the secretory pathway, including cytokines, hormones, integrins, other proteases, and also pathogen-derived proteins. It is likely that the level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d541d4bf3d44e4ff666a1d41ff25e7
https://doi.org/10.1016/j.jim.2010.11.008
https://doi.org/10.1016/j.jim.2010.11.008
Publikováno v:
Allergy. 64:539-550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::babace1f9360c72e3f5bdcf87ef97ecc
https://doi.org/10.1111/j.1398-9995.2009.02077.x
https://doi.org/10.1111/j.1398-9995.2009.02077.x
Publikováno v:
Metabolomics. 4:191-201
Objective To investigate the metabolic profile of serum and urine samples from 23 female patients with Parkinson’s disease (PD) and 23 age and sex-matched controls. Methods We used gas chromatography coupled to mass spectrometry to detect metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbb100635a4eda43288c9bf796f09c7
https://doi.org/10.1007/s11306-008-0111-9
https://doi.org/10.1007/s11306-008-0111-9
Autor:
David J. Grainger, Daniel W. Wheeler, Jack F. Price, Andrew J. Grant, Jill Reckless, David K. Menon, John S. Beech, Pietro Mastroeni
Publikováno v:
Journal of Neuroimmunology. 184:198-208
Chemokines help to establish cerebral inflammation after ischemia, which comprises a major component of secondary brain injury. The CXCR4 chemokine receptor system induces neural stem cell migration, and hence has been implicated in brain repair. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6861d1f6d9b19b927c3cb806d6969580
https://doi.org/10.1016/j.jneuroim.2006.12.015
https://doi.org/10.1016/j.jneuroim.2006.12.015
Autor:
Sarah Griffiths, David J. Grainger
Publikováno v:
BioEssays. 28:629-641
Metabolic Syndrome is a cluster of risk factors (including obesity, hypertension and insulin resistance), which is associated with late-onset diabetes and coronary heart disease. Elevated levels of the protease inhibitor PAI-1 are well-known molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85c07edc0dc5471532f6e4ae70202b6
https://doi.org/10.1002/bies.20418
https://doi.org/10.1002/bies.20418
Autor:
Peter R. Schofield, David J. Grainger
Publikováno v:
Circulation. 112:3018-3024
Received December 21, 2004; revision received May 18, 2005; accepted June 2, 2005. Tamoxifen is a member of the triphenylethylene class of drugs (Figure 1), originally derived from the estrogen-mimetic hydrocarbon stilbene.1 Like other members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271bf785adc278844e4e239519089235
https://doi.org/10.1161/circulationaha.104.531178
https://doi.org/10.1161/circulationaha.104.531178
Publikováno v:
The Journal of Immunology. 173:6366-6375
Apolipoprotein E (apoE) is a 34-kDa glycoprotein involved in lipoprotein transport through interaction with the low-density lipoprotein receptor and related receptors. Recently, it has become clear that apoE binding to its receptors plays a role both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e352d32470db3751081c535b2a3ded95
https://doi.org/10.4049/jimmunol.173.10.6366
https://doi.org/10.4049/jimmunol.173.10.6366