Zobrazeno 1 - 10
of 138
pro vyhledávání: '"David J Grainger"'
Autor:
David J. Grainger
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 5:779-780
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb41b547897b164553fc124fd3fe586
https://doi.org/10.2174/1389557054867066
https://doi.org/10.2174/1389557054867066
Autor:
Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The molecular basis of activin receptor-like kinase 1 (ALK1)-mediated endothelial bone morphogenetic protein (BMP) signalling is not fully understood. Here, the authors present crystal structures of the BMP10:ALK1 and prodomain-bound BMP9:ALK1 comple
Externí odkaz:
https://doaj.org/article/c95928c8f6c04cf69fb1889c1608aeab
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008460 (2020)
Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to different conditions? Here, we explore a biophysical cost-benefit principle, namely that the cell s
Externí odkaz:
https://doaj.org/article/bbede27205254f31bdfbbb913921e922
Autor:
Grainger, David J.
Publikováno v:
Mini Reviews in Medicinal Chemistry; September 2005, Vol. 5 Issue: 9 p779-780, 2p
Autor:
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17152 (2011)
GABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs. Recent work has shown that Cys-loop receptors are pr
Externí odkaz:
https://doaj.org/article/23173b15fc8b4b9690a691153a3c3a03
A series of 3-acylaminocaprolactams are inhibitors of chemokine-induced chemotaxis. Branching of the side chain alpha-carbon provides highly potent inhibitors of a range of CC and CXC chemokines. The most potent compound has an ED(50) of 40 pM. Selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f3b22c06f765c80cc93f57a539daa4
https://ora.ox.ac.uk/objects/uuid:817ddac0-7e75-4b21-aaae-64d29e2fe93d
https://ora.ox.ac.uk/objects/uuid:817ddac0-7e75-4b21-aaae-64d29e2fe93d
Autor:
Gemma L. Bourne, David J. Grainger
Publikováno v:
Journal of Immunological Methods. 364:101-108
Furin is a serine endoprotease that is responsible for the proteolytic processing of proteins within the secretory pathway, including cytokines, hormones, integrins, other proteases, and also pathogen-derived proteins. It is likely that the level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d541d4bf3d44e4ff666a1d41ff25e7
https://doi.org/10.1016/j.jim.2010.11.008
https://doi.org/10.1016/j.jim.2010.11.008
Publikováno v:
Allergy. 64:539-550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::babace1f9360c72e3f5bdcf87ef97ecc
https://doi.org/10.1111/j.1398-9995.2009.02077.x
https://doi.org/10.1111/j.1398-9995.2009.02077.x
Publikováno v:
Metabolomics. 4:191-201
Objective To investigate the metabolic profile of serum and urine samples from 23 female patients with Parkinson’s disease (PD) and 23 age and sex-matched controls. Methods We used gas chromatography coupled to mass spectrometry to detect metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbb100635a4eda43288c9bf796f09c7
https://doi.org/10.1007/s11306-008-0111-9
https://doi.org/10.1007/s11306-008-0111-9
Autor:
David J. Grainger, Daniel W. Wheeler, Jack F. Price, Andrew J. Grant, Jill Reckless, David K. Menon, John S. Beech, Pietro Mastroeni
Publikováno v:
Journal of Neuroimmunology. 184:198-208
Chemokines help to establish cerebral inflammation after ischemia, which comprises a major component of secondary brain injury. The CXCR4 chemokine receptor system induces neural stem cell migration, and hence has been implicated in brain repair. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6861d1f6d9b19b927c3cb806d6969580
https://doi.org/10.1016/j.jneuroim.2006.12.015
https://doi.org/10.1016/j.jneuroim.2006.12.015