Zobrazeno 1 - 10
of 223
pro vyhledávání: '"David J Glass"'
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
Neil Johns, Shinji Hatakeyama, Nathan A Stephens, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, James A Ross, Ronenn Roubenoff, David J Glass, Carsten Jacobi, Kenneth C H Fearon
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83618 (2014)
BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. One impediment towards the effective treatment of cachexia is a valid
Externí odkaz:
https://doaj.org/article/137790f226e44fdeb5933e061427f34e
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
Autor:
Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai, David J. Glass
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In order to discover
Externí odkaz:
https://doaj.org/article/a43926fa120c4d5db9e644d5c5986045
Autor:
Dana J. Murdock, Ning Wu, Joseph S. Grimsby, Roberto A. Calle, Stephen Donahue, David J. Glass, Mark W. Sleeman, Robert J. Sanchez
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Background Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of muscle and function i
Externí odkaz:
https://doaj.org/article/4f56a81b31534134b1d3d6277a01fa08
Autor:
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.
Externí odkaz:
https://doaj.org/article/f20a08691add485199dd53a06c8fd523
Autor:
Hui-Hua Li, Monte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass, Cam Patterson
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/19e7cd96401f4cd6a4a35c1deeaa80f2
Autor:
Tea Shavlakadze, Melody Morris, Jian Fang, Sharon X. Wang, Jiang Zhu, Weihua Zhou, Herman W. Tse, Ricardo Mondragon-Gonzalez, Guglielmo Roma, David J. Glass
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3263-3273.e3 (2019)
Summary: To understand the changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produce a multi-time point age-related gene expression signature (AGES) from liver
Externí odkaz:
https://doaj.org/article/dec339453fa64d06ac15ef5d74a9de35
PDF file - 102K, Contains supplemental information regarding antibodies used, cell growth and apoptosis assays, a tissue expression profile, microarray analysis and statistics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de46c34f34943c7b537aa41a98035dc
https://doi.org/10.1158/0008-5472.22395969.v1
https://doi.org/10.1158/0008-5472.22395969.v1