Zobrazeno 1 - 10
of 132
pro vyhledávání: '"David J Garfinkel"'
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Background Many computational methods have been developed to detect non-reference transposable element (TE) insertions using short-read whole genome sequencing data. The diversity and complexity of such methods often present challenges to ne
Externí odkaz:
https://doaj.org/article/5db00dade9bc47d08c5e99a9182ae814
Autor:
Matthew A. Cottee, Sean L. Beckwith, Suzanne C. Letham, Sarah J. Kim, George R. Young, Jonathan P. Stoye, David J. Garfinkel, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
In Saccharomyces cerevisiae, unchecked proliferation of Ty1 retrotransposons is controlled by the process of copy number control (CNC), which requires the p22/p18 protein, translated from an internal transcript within the Ty1 GAG gene. Here, the auth
Externí odkaz:
https://doaj.org/article/aae81f4107a84d3a99658b2407f95119
Autor:
Małgorzata Zawadzka, Angelika Andrzejewska-Romanowska, Julita Gumna, David J. Garfinkel, Katarzyna Pachulska-Wieczorek
Publikováno v:
Viruses, Vol 14, Iss 9, p 2007 (2022)
The structural transitions RNAs undergo during trafficking are not well understood. Here, we used the well-developed yeast Ty1 retrotransposon to provide the first structural model of genome (g) RNA in the nucleus from a retrovirus-like transposon. T
Externí odkaz:
https://doaj.org/article/34dfcc67b7da4c7e95e0b42daeaf8e7b
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008632 (2020)
Transposable elements constitute a large fraction of most eukaryotic genomes. Insertion of mobile DNA sequences typically has deleterious effects on host fitness, and thus diverse mechanisms have evolved to control mobile element proliferation. Mobil
Externí odkaz:
https://doaj.org/article/1163b769c3f3435ca8cbad180c0b1cce
Publikováno v:
Microscopy and Microanalysis. 28:1116-1119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020b05a28bd57aadc210ca658ba01475
https://doi.org/10.1017/s1431927622004718
https://doi.org/10.1017/s1431927622004718
Autor:
Sean L. Beckwith, Emily J. Nomberg, Abigail C. Newman, Jeannette V. Taylor, Ricardo C. Guerrero, David J. Garfinkel
Retrotransposons and retroviruses shape genome evolution and can negatively impact genome function.Saccharomyces cerevisiaeand its close relatives harbor several families of LTR-retrotransposons, the most abundant being Ty1 in several laboratory stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf953588c3f893ddfb517849b638311
https://doi.org/10.1101/2023.02.27.530227
https://doi.org/10.1101/2023.02.27.530227
Autor:
Jingxuan Chen, Holly McQueary, David W. Hall, Peter Philippsen, David J. Garfinkel, Casey M. Bergman
Publikováno v:
Microbiology Resource Announcements
Here, we report an essentially complete genome assembly for the Ty1-less Saccharomyces paradoxus strain DG1768 (derivative of strain 337) based on PacBio and Illumina shotgun sequence data. We also document the genetic alterations that make this yeas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455ea3155649e81a25ad7b6f94f8daa3
https://doi.org/10.1128/mra.00868-21
https://doi.org/10.1128/mra.00868-21
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005571 (2015)
A novel form of copy number control (CNC) helps maintain a low number of Ty1 retrovirus-like transposons in the Saccharomyces genome. Ty1 produces an alternative transcript that encodes p22, a trans-dominant negative inhibitor of Ty1 retrotranspositi
Externí odkaz:
https://doaj.org/article/e219c192d9154ff2abe6afc581eddfaa
Autor:
Julita Gumna, Katarzyna Pachulska-Wieczorek, Angelika Andrzejewska-Romanowska, David J. Garfinkel
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9103, p 9103 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9103, p 9103 (2021)
A universal feature of retroelement propagation is the formation of distinct nucleoprotein complexes mediated by the Gag capsid protein. The Ty1 retrotransposon Gag protein from Saccharomyces cerevisiae lacks sequence homology with retroviral Gag, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203ccaa70c0219300293058b3992cf12
Autor:
Katarzyna Pachulska-Wieczorek, Hyo Won Ahn, David J. Garfinkel, Julita Gumna, Katarzyna J. Purzycka
Publikováno v:
RNA Biology
During replication of long terminal repeat (LTR)-retrotransposons, their proteins and genome (g) RNA assemble into virus-like particles (VLPs) that are not infectious but functionally related to retroviral virions. Both virions and VLPs contain gRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1221d516dc292edaa6f62de48afa369d
http://europepmc.org/articles/PMC6844567
http://europepmc.org/articles/PMC6844567