Zobrazeno 1 - 10
of 98
pro vyhledávání: '"David J Fulton"'
Autor:
Yiming Xu, Yong Wang, Siyuan Yan, Yaqi Zhou, Qiuhua Yang, Yue Pan, Xianqiu Zeng, Xiaofei An, Zhiping Liu, Lina Wang, Jiean Xu, Yapeng Cao, David J Fulton, Neal L Weintraub, Zsolt Bagi, Md Nasrul Hoda, Xiaoling Wang, Qinkai Li, Mei Hong, Xuejun Jiang, Detlev Boison, Christian Weber, Chaodong Wu, Yuqing Huo
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 9, Pp 1263-1278 (2017)
Abstract The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function of the adenosine‐metabolizing enzyme adenosine kinase (ADK) and the intracellular adenosine levels influence angiogen
Externí odkaz:
https://doaj.org/article/76c3e705dd9743499adc42614850974d
Autor:
Anita Kovacs-Kasa, Abdelrahman A. Zaied, Silvia Leanhart, Murat Koseoglu, Supriya Sridhar, Rudolf Lucas, David J. Fulton, Jose A. Vazquez, Brian H. Annex
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT The vascular endothelial injury occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, but the mechanisms are poorly understood. We sought to determine the frequency and type of cytokine elevations and their relat
Externí odkaz:
https://doaj.org/article/5c044d2917e34f7cb29179a1d4784fb7
Autor:
Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Jianqiu Zou, Jian Shen, Yaqi Zhou, Qingen Da, Xiaoxiao Mao, Sarah Lu, David J. Fulton, Neal L. Weintraub, Zsolt Bagi, Mei Hong, Yuqing Huo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Myeloid cells, including monocytes/macrophages, primarily rely on glucose and lipid metabolism to provide the energy and metabolites needed for their functions and survival. AMP-activated protein kinase (AMPK, its gene is PRKA for human, Prka for rod
Externí odkaz:
https://doaj.org/article/4c62fe6b563b449385c46a47f4e5967a
Autor:
Qiuhua Yang, Jiean Xu, Qian Ma, Zhiping Liu, Varadarajan Sudhahar, Yapeng Cao, Lina Wang, Xianqiu Zeng, Yaqi Zhou, Min Zhang, Yiming Xu, Yong Wang, Neal L. Weintraub, Chunxiang Zhang, Tohru Fukai, Chaodong Wu, Lei Huang, Zhen Han, Tao Wang, David J. Fulton, Mei Hong, Yuqing Huo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by
Externí odkaz:
https://doaj.org/article/befd6b37207d47fb8d266efd4020896c
Autor:
Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, Haroldo A. Toque, Zheng Dong, Xuejun Jiang, David J. Fulton, Neal L. Weintraub, Qinkai Li, Zsolt Bagi, Mei Hong, Detlev Boison, Chaodong Wu, Yuqing Huo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibit
Externí odkaz:
https://doaj.org/article/a0da5f7197174e109b38d9b593754ec6
Autor:
Zhiping Liu, Siyuan Yan, Jiaojiao Wang, Yiming Xu, Yong Wang, Shuya Zhang, Xizhen Xu, Qiuhua Yang, Xianqiu Zeng, Yaqi Zhou, Xuejiao Gu, Sarah Lu, Zhongjie Fu, David J. Fulton, Neal L. Weintraub, Ruth B. Caldwell, Wenbo Zhang, Chaodong Wu, Xiao-Ling Liu, Jiang-Fan Chen, Aftab Ahmad, Ismail Kaddour-Djebbar, Mohamed Al-Shabrawey, Qinkai Li, Xuejun Jiang, Ye Sun, Akrit Sodhi, Lois Smith, Mei Hong, Yuqing Huo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via t
Externí odkaz:
https://doaj.org/article/cc1ca07b42ef444d8f0ceca3934d4c40
Autor:
Mohamed M. Meghil, Omnia K. Tawfik, Mahmoud Elashiry, Mythilypriya Rajendran, Roger M. Arce, David J. Fulton, Patricia V. Schoenlein, Christopher W. Cutler
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, a
Externí odkaz:
https://doaj.org/article/6ea3cb09dc904a14a12b499acabe386f
Autor:
Xiangqin He, Kunzhe Dong, Jian Shen, Guoqing Hu, James D. Mintz, Reem T. Atawia, Juanjuan Zhao, Xiuxu Chen, Robert W. Caldwell, Meixiang Xiang, David W. Stepp, David J. Fulton, Jiliang Zhou
Publikováno v:
Gastroenterology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945cd74d0b122ae2c66e3638d35cbf7c
https://doi.org/10.1053/j.gastro.2023.03.229
https://doi.org/10.1053/j.gastro.2023.03.229
Autor:
Joshua T. Butcher, James D. Mintz, Sebastian Larion, Shuiqing Qiu, Ling Ruan, David J. Fulton, David W. Stepp
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 16 (2018)
Background Obesity compromises cardiometabolic function and is associated with hypertension and chronic kidney disease. Exercise ameliorates these conditions, even without weight loss. Although the mechanisms of exercise's benefits remain unclear, au
Externí odkaz:
https://doaj.org/article/529139d7ac6748dab0f33a33c3d97521
Autor:
Joshua T. Butcher, M. Irfan Ali, Merry W. Ma, Cameron G. McCarthy, Bianca N. Islam, Lauren G. Fox, James D. Mintz, Sebastian Larion, David J. Fulton, David W. Stepp
Publikováno v:
Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017)
Abstract The objective of this study is to test the hypothesis that increased muscle mass has positive effects on cardiovascular function. Specifically, we tested the hypothesis that increases in lean body mass caused by deletion of myostatin improve
Externí odkaz:
https://doaj.org/article/3130dbc9b6c046c89bfe59176f62f346