Zobrazeno 1 - 10
of 118
pro vyhledávání: '"David J Feith"'
Autor:
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193429 (2018)
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT)
Externí odkaz:
https://doaj.org/article/6da4a6d2bd7b4fa1a0f2b156ec807732
Autor:
Katharine B. Moosic, Thomas L. Olson, Mark Freijat, Samara Khalique, Cait E. Hamele, Bryna Shemo, Jesse Boodoo, William Baker, Gitanjali Khurana, Matthew Schmachtenberg, Tristin Duffy, Aakrosh Ratan, Erika Darrah, Felipe Andrade, Marieke Jones, Kristine C. Olson, David J. Feith, Donald L. Kimpel, Thomas P. Loughran
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesLarge granular lymphocyte (LGL) leukemia is a rare hematologic malignancy characterized by clonal expansion of cytotoxic T-cells frequent somatic activating STAT3 mutations. Based on the disease overlap between LGL leukemia rheumatoid arthr
Externí odkaz:
https://doaj.org/article/f51efdc006224865896221b7b45fa0ad
Autor:
Lindsay K Ryland, Ushma A Doshi, Sriram S Shanmugavelandy, Todd E Fox, Cesar Aliaga, Kathleen Broeg, Kendall Thomas Baab, Megan Young, Osman Khan, Jeremy K Haakenson, Nancy Ruth Jarbadan, Jason Liao, Hong-Gang Wang, David J Feith, Thomas P Loughran, Xin Liu, Mark Kester
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84648 (2013)
Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unk
Externí odkaz:
https://doaj.org/article/52a8d45810a54de489ffc56023744a35
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9825 (2024)
The tumor-suppressor sphingolipid ceramide is recognized as a key participant in the cytotoxic mechanism of action of many types of chemotherapy drugs, including anthracyclines, Vinca alkaloids, the podophyllotoxin etoposide, taxanes, and the platinu
Externí odkaz:
https://doaj.org/article/4d0c581bb64441318ce014ad4da87a7b
Autor:
Mireia Casasampere, Johnson Ung, Alejandro Iñáñez, Carine Dufau, Kazuhito Tsuboi, Josefina Casas, Su-Fern Tan, David J. Feith, Nathalie Andrieu-Abadie, Bruno Segui, Thomas P. Loughran, Jr., José Luis Abad, Gemma Fabrias
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100520- (2024)
Lipid amidases of therapeutic relevance include acid ceramidase (AC), N-acylethanolamine-hydrolyzing acid amidase, and fatty acid amide hydrolase (FAAH). Although fluorogenic substrates have been developed for the three enzymes and high-throughput me
Externí odkaz:
https://doaj.org/article/cbc54b7eb8e74f508add3ca8fe1b0079
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 919-923 (2022)
Abstract Large granular lymphocyte leukemia is a rare chronic lymphoproliferative disorder of cytotoxic cells. Other hematological malignancies such as CLL and multiple myeloma have been associated with poor vaccination response and markedly increase
Externí odkaz:
https://doaj.org/article/1ad749cb65a5430880773ac363014c38
Autor:
Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su-Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. Viny, David J. Feith, Ross L. Levine, Hong-Gang Wang, Thomas P. Loughran, Jr, Arati Sharma, Mark Kester, David F. Claxton
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2598-2603 (2019)
Externí odkaz:
https://doaj.org/article/c4625d35b02b4dee8bf8588d9b18b16d
Autor:
Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, Matthew R. MacDougall, Miki Kassai, Noha Abdelmageed, Todd E. Fox, Mark Kester, Thomas P. Loughran, Jr., Jose' L. Abad, Gemma Fabrias, Su-Fern Tan, David J. Feith, David F. Claxton, Sarah Spiegel, Kelsey H. Fisher-Wellman, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in
Externí odkaz:
https://doaj.org/article/fd54fe2e27784a42b78f98d42562f8fa
Autor:
Weiling Li, Lei Yang, Robert S. Harris, Lin Lin, Thomas L. Olson, Cait E. Hamele, David J. Feith, Thomas P. Loughran, Mary Poss
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum of patients with LGL leukemia. Cult
Externí odkaz:
https://doaj.org/article/12f89a5535cd4d0294bfaf00b20929b5
Autor:
Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David F. Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, Jr.
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1078-1086 (2019)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission c
Externí odkaz:
https://doaj.org/article/a185154e7e4d47c99c08cbdef0bdcbba