Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David J De George"'
Autor:
Tingting Ge, Amber‐Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz‐Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Objectives Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune‐related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effect
Externí odkaz:
https://doaj.org/article/2f238a260da54aefb12d7ef799742c6b
Autor:
Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibitin
Externí odkaz:
https://doaj.org/article/0e2a9e262b5049768e050d08ba434b1c
Autor:
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Publikováno v:
Frontiers in Cell and Developmental Biology. 11
Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f232c32577bf3af5457b1ba248188d1b
https://doi.org/10.3389/fcell.2023.1205590
https://doi.org/10.3389/fcell.2023.1205590
Autor:
Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v:
Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97fab22d01f9071dfdfc3f0f26da54e5
https://pubmed.ncbi.nlm.nih.gov/35476975
https://pubmed.ncbi.nlm.nih.gov/35476975
Autor:
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Nicola Principe, Erwan Brémaud, David J. De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas W.H. Kay, Helen E. Thomas
Publikováno v:
Cell Reports. 39:110747
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940f280685afe54edca60458f97f81f9
https://doi.org/10.1016/j.celrep.2022.110747
https://doi.org/10.1016/j.celrep.2022.110747