Zobrazeno 1 - 10
of 78
pro vyhledávání: '"David J Cousins"'
Autor:
Paul E Pfeffer, Haw Lu, Elizabeth H Mann, Yin-Huai Chen, Tzer-Ren Ho, David J Cousins, Chris Corrigan, Frank J Kelly, Ian S Mudway, Catherine M Hawrylowicz
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200040 (2018)
BACKGROUND:Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma. OBJECTIVES:Mechanistic cell culture experiments were
Externí odkaz:
https://doaj.org/article/f3d696009af0456f861023d1f64c4a4a
Autor:
Anna Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Konstantinos Tsioulos, Evie Haye, Emily PS Lam, Joanna Kelly, Janet L Peacock, Sun Ying, Mohamed H Shamji, David J Cousins, Stephen R Durham, Stephen J Till
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 3, Iss 10 (2016)
Background: We previously reported that repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses, comparable with conventional high-dose subcutaneous and sublingual immunotherapy. Object
Externí odkaz:
https://doaj.org/article/f8daeea21926466a8c416e8e936ec20e
Autor:
Peter McErlean, Audrey Kelly, Jaideep Dhariwal, Max Kirtland, Julie Watson, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Michael R. Edwards, Sebastian L. Johnston, Paul Lavender
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of t
Externí odkaz:
https://doaj.org/article/7cb4bd32b5e64d748ae7401e5f6f18c3
Publikováno v:
New England Journal of Medicine. 385:1669-1679
Interleukin-23 has been implicated in airway inflammation that is mediated by type 2 and type 17 cytokines. Whether targeting interleukin-23 in the treatment of asthma improves disease control and reduces airway inflammation is unclear.We conducted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6beea956797506cc1c8e9f145453c864
https://doi.org/10.1056/nejmoa2030880
https://doi.org/10.1056/nejmoa2030880
Autor:
David J. Cousins, Ernie Wong, Trevor T. Hansel, David A. Jackson, Ajerico del Rosario, Eteri Bakhsoliani, Jaideep Dhariwal, Malte Paulsen, Michael R. Edwards, Aoife Cameron, Ross P. Walton, Belen Trujillo-Torralbo, Sebastian L. Johnston
Rationale Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well-characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498121463a7b8682bb4b9fa01c689153
http://hdl.handle.net/10044/1/92512
http://hdl.handle.net/10044/1/92512
Autor:
Jaideep Dhariwal, Aoife Cameron, Ernie Wong, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ajerico del Rosario, Eteri Bakhsoliani, Tatiana Kebadze, Mark Almond, Hugo Farne, Leila Gogsadze, Julia Aniscenko, Batika M. J. Rana, Trevor T. Hansel, David J. Jackson, Onn Min Kon, Michael R. Edwards, Roberto Solari, David J. Cousins, Ross P. Walton, Sebastian L. Johnston, Paul Lavender, Hannah Gould, David Cousins, Antoon J. van Oosterhout, Nathan W. Bartlett, Patrick Mallia, Jerico del Rosario, Janet L. Smith, Matthew J. Edwards, Karen Affleck, Nil Turan Jurdzinski, Veronique Birault, Peter McErlean, Yu-Chang Wu, Nadine Upton, Ismael Ranz Jimenez
Publikováno v:
Am J Respir Crit Care Med
RATIONALE: Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816761f5244c7709ec80777271040f45
https://europepmc.org/articles/PMC8786078/
https://europepmc.org/articles/PMC8786078/
Autor:
David J. Cousins, Ian Sayers, Dominick E. Shaw, Rebecca Cooper, Michael A. Portelli, Marco Londei, Simon R. Johnson, Christopher E. Brightling
Publikováno v:
Airway cell biology and immunopathology.
Rhinovirus (RV) is a major trigger of asthma exacerbations. RV infection of the bronchial epithelium leads to interleukin-33 (IL-33) release, driving local inflammation. The role of IL-33 release in asthmatic airways on virally induced mechanisms in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52f2626df89ffcc6825d690403b9898f
https://doi.org/10.1183/13993003.congress-2020.617
https://doi.org/10.1183/13993003.congress-2020.617
Publikováno v:
Paediatric asthma and allergy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::270c547d8d8d14fc82fd504745c27503
https://doi.org/10.1183/13993003.congress-2020.1207
https://doi.org/10.1183/13993003.congress-2020.1207
Autor:
Yi-Ling Chen, David Johnson, Clare S. Hardman, Jillian L. Barlow, C. L. Fonseka, Janina Nahler, Alison Simmons, Maryam Salimi, Marta Jagielowicz, Andrew N. J. McKenzie, Emmanouela Repapi, David J. Cousins, Graham S. Ogg, Daniele Corridoni
Publikováno v:
Sci Immunol
Cutaneous group 2 innate lymphoid cells (ILC2) are spatially and epigenetically poised to respond to barrier compromise and associated immunological threats. ILC2, lacking rearranged antigen-specific receptors, are primarily activated by damage-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbee7428535b8576aa9da29940a0cbb
https://pubmed.ncbi.nlm.nih.gov/34021026
https://pubmed.ncbi.nlm.nih.gov/34021026
Autor:
Sarah Parker, David J. Cousins, Sarah Glover, Salman Siddiqui, Marcia Soares, Adam K. A. Wright, Michelle Craner, Michelle Bourne, Sarah Edwards, Helen Evans, Andrew Marvin, Jamie McCarthy, Tracy Thornton, Christopher E. Brightling, Liesl Carr, Sarah Diver
Publikováno v:
Allergy
Additional supporting information may be found online in the Supporting Information section at the end of the article.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da64eadfae3093773ee87e063f0d74e
https://doi.org/10.1111/all.13879
https://doi.org/10.1111/all.13879