Zobrazeno 1 - 10
of 129
pro vyhledávání: '"David J Christini"'
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005430 (2017)
The ability to experimentally perturb biological systems has traditionally been limited to static pre-programmed or operator-controlled protocols. In contrast, real-time control allows dynamic probing of biological systems with perturbations that are
Externí odkaz:
https://doaj.org/article/ef075f59f68e49a7900846b09a88d561
Autor:
Kemar Brown, Stephanie Legros, Francis A Ortega, Yunkai Dai, Michael Xavier Doss, David J Christini, Richard B Robinson, Ann C Foley
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189818 (2017)
In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. H
Externí odkaz:
https://doaj.org/article/b5f7aed9224a42478ecb7be635eb5f22
Autor:
Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)
The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations
Externí odkaz:
https://doaj.org/article/955d66251d1f439a96259fddd41f95af
Autor:
Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82951 (2013)
Aging increases the risk of cardiac pathologies including atrial fibrillation and can alter myocardial responsiveness to therapeutic agents. Here, seeking molecular correlates of myocardial aging processes, we performed global "whole transcript" anal
Externí odkaz:
https://doaj.org/article/f402597591de49fbb3bba7b484b83cbb
Autor:
Stephen eGaeta, David J Christini
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Cardiac repolarization alternans is a rhythm disturbance of the heart in which rapid stimulation elicits a beat-to-beat alternation in the duration of action potentials and magnitude of intracellular calcium transients in individual cardiac myocytes.
Externí odkaz:
https://doaj.org/article/c4265849a7234fd8a9a5d48e2747d096
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 2, p e1002390 (2012)
Atrial fibrillation, a common cardiac arrhythmia, often progresses unfavourably: in patients with long-term atrial fibrillation, fibrillatory episodes are typically of increased duration and frequency of occurrence relative to healthy controls. This
Externí odkaz:
https://doaj.org/article/d5e1779b4ad148299a55120c630d9782
Autor:
Byron N Roberts, David J Christini
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47117 (2012)
Myocardial ischemia-reperfusion (IR) injury represents a constellation of pathological processes that occur when ischemic myocardium experiences a restoration of perfusion. Reentrant arrhythmias, which represent a particularly lethal manifestation of
Externí odkaz:
https://doaj.org/article/aa11d8d8781a471486983fee70573309
Autor:
Byron N Roberts, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002241 (2011)
Reperfusion injury results from pathologies of cardiac myocyte physiology that develop when previously ischemic myocardium experiences a restoration of normal perfusion. Events in the development of reperfusion injury begin with the restoration of a
Externí odkaz:
https://doaj.org/article/e2210c65c06548518518355f66deefc4
Autor:
Alexander P. Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P. de Boer, Gary R. Mirams, David J. Christini, Trine Krogh-Madsen
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, and the computational models built from the resultant data, has overlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ed2bc62fb226b8bcd15bdcb5691ce2
https://doi.org/10.1101/2022.10.13.511949
https://doi.org/10.1101/2022.10.13.511949
