Zobrazeno 1 - 10
of 1 081
pro vyhledávání: '"David J Brooks"'
Autor:
Kallol Ray Chaudhuri, Jose Manuel Rojo, Anthony H V Schapira, David J Brooks, Fabrizio Stocchi, Per Odin, Angelo Antonini, Richard G Brown, Pablo Martinez-Martin
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150130 (2016)
Externí odkaz:
https://doaj.org/article/7fbeecacc4224f01b12d73d96729bdc6
Autor:
David J Brooks
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 39-47 (2008)
David J BrooksDivision of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UKAbstract: After 40 years of clinical experience, levodopa remains the gold standard treatment for Parkinson’s disease (PD) despite the re
Externí odkaz:
https://doaj.org/article/97669d152cbb42ba97bbf2f8b725cd6f
Autor:
Kristian Juul-Madsen, Peter Parbo, Rola Ismail, Peter L. Ovesen, Vanessa Schmidt, Lasse S. Madsen, Jacob Thyrsted, Sarah Gierl, Mihaela Breum, Agnete Larsen, Morten N. Andersen, Marina Romero-Ramos, Christian K. Holm, Gregers R. Andersen, Huaying Zhao, Peter Schuck, Jens V. Nygaard, Duncan S. Sutherland, Simon F. Eskildsen, Thomas E. Willnow, David J. Brooks, Thomas Vorup-Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep
Externí odkaz:
https://doaj.org/article/81c39ad41509420b82e48e637c1da445
Autor:
Kallol Ray Chaudhuri, Jose Manuel Rojo, Anthony H V Schapira, David J Brooks, Fabrizio Stocchi, Per Odin, Angelo Antonini, Richard G Brown, Pablo Martinez-Martin
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57221 (2013)
BackgroundNon-motor symptoms are present in Parkinson's disease (PD) and a key determinant of quality of life. The Non-motor Symptoms Scale (NMSS) is a validated scale that allows quantifying frequency and severity (burden) of NMS. We report a propos
Externí odkaz:
https://doaj.org/article/7f23afca1ad64ec09e622038810af64e
Autor:
Lucy J Garvey, Nicola Pavese, Anil Ramlackhansingh, Emma Thomson, Joanna M Allsop, Marios Politis, Ranjababu Kulasegaram, Janice Main, David J Brooks, Simon D Taylor-Robinson, Alan Winston
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e38980 (2012)
BackgroundMicroglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection
Externí odkaz:
https://doaj.org/article/c124816a84824d139ceb07f51771943e
Autor:
Hilmar P. Sigurdsson, Lisa Alcock, Michael Firbank, Ross Wilson, Philip Brown, Ross Maxwell, Elizabeth Bennett, Nicola Pavese, David J. Brooks, Lynn Rochester
Publikováno v:
NeuroImage, Vol 288, Iss , Pp 120531- (2024)
Gait is an excellent indicator of physical, emotional, and mental health. Previous studies have shown that gait impairments in ageing are common, but the neural basis of these impairments are unclear. Existing methodologies are suboptimal and novel p
Externí odkaz:
https://doaj.org/article/c096ef344398443a92479200422bd187
Publikováno v:
Brain Stimulation, Vol 16, Iss 1, Pp 394-395 (2023)
Externí odkaz:
https://doaj.org/article/d44686ff309e4b20b3edd8807fa50c15
Autor:
Pernille L. Kjeldsen, Peter Parbo, Kim V. Hansen, Joel F.A. Aanerud, Rola Ismail, Peter H. Nissen, Rikke B. Dalby, Malene F. Damholdt, Per Borghammer, David J. Brooks
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100048- (2022)
Introduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer’s disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has
Externí odkaz:
https://doaj.org/article/d4f233cd10d145528054e34755010fb9
Autor:
Grazia Daniela Femminella, Eleni Frangou, Sharon B. Love, Gail Busza, Clive Holmes, Craig Ritchie, Robert Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben R. Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Ramin Nilforooshan, Ajay Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, David J. Brooks, Anthony Peter Passmore, Clive Ballard, Paul Edison
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue currently approved for type 2 diabetes and obesity. Preclinical evidence in transgenic models of Alzheimer’s disease suggests that liraglutide exerts neuroprotective effe
Externí odkaz:
https://doaj.org/article/3a0e309bbdd6411c977edcbdc27ca743
Autor:
Lasse S. Madsen, Peter Parbo, Rola Ismail, Hanne Gottrup, Leif Østergaard, David J. Brooks, Simon F. Eskildsen
Publikováno v:
Madsen, L S, Parbo, P, Ismail, R, Gottrup, H, Østergaard, L, Brooks, D J & Eskildsen, S F 2023, ' Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease ', Neurobiology of Aging, vol. 123, pp. 1-9 . https://doi.org/10.1016/j.neurobiolaging.2022.12.006
Alterations in cerebral perfusion is increasingly considered to play a crucial role in Alzheimer’s disease (AD) and together with accumulated amyloid-β, deficiencies in the brain microvascular circulation may result in local hypoxia. Here, we stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f17fa485c9c1bfdd0cc6088ddc83e
https://doi.org/10.1016/j.neurobiolaging.2022.12.006
https://doi.org/10.1016/j.neurobiolaging.2022.12.006