Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David J Brierley"'
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000199 (2009)
Neural maps are emergent, highly ordered structures that are essential for organizing and presenting synaptic information. Within the embryonic nervous system of Drosophila motoneuron dendrites are organized topographically as a myotopic map that ref
Externí odkaz:
https://doaj.org/article/42765f23854043a39d4509b044f12360
Autor:
Andy Neely, Nancy T. Malintan, Menelas N. Pangalos, Haidee Pitt, Molly A. Taylor, Melanie Leveridge, Douglas Ross-Thriepland, Roger Clark, Simon Fish, Rahul Sharma, Anna Cuthbert, Ruud M. DeWildt, Stuart M. Baddeley, David J. Nicholls, Abigail Marklew, David J. Brierley, Palwinder K. Mander, Christopher A. Brown, Penny A. Smee, Jane Elliott, Hannah Duvoisin, Patrick H. Maxwell, Clive Green, Alexandra L. Orton, Giles Ratcliffe, Julie A. Douthwaite, Gareth Browne, Paula M. Allen, Rob Howes, Ian Richards, David G. Tew, Julian D. Phipps, Shane Weaver, Steve Rees, Ian Goodfellow, John R. Ferdinand, Oona Delpuech, Joost van Kempen, Matthieu Chodorge, Fred Kuenzi, Craig Hewitt, Emma Koppe, Ian D. Waddell, Abhishek Upadhyay, Thomas Hill, Charlotte Ashby, Nalini Mehta, Jon G. Bartlett, Christopher Brankin, Chris Abell
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e7691c6b13828a9439674e7cb3af4c
https://doi.org/10.21203/rs.3.rs-637020/v1
https://doi.org/10.21203/rs.3.rs-637020/v1
Autor:
Cassie Messenger, Laurie J. Gordon, Simon C. C. Lucas, Aaron T. Cheng, Kelly M Gatfield, John P. Evans, Emma J. Jones, Mahnoor Mahmood, Charles S. Lay, Charlotte E. Carver, Douglas Sammon, Antonia J. Lewis, Alexander N Phillipou, Syandan Chakraborty, Luke A Greenhough, Peter D. Craggs, David J Brierley
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(2)
Malfunctions in the basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are implicated in a number of cancers and immunological and neurodegenerative conditions. Within GlaxoSmithKline (GSK) we have ut
Publikováno v:
The Journal of Comparative Neurology. 520:1629-1649
Motoneurons are key points of convergence within motor networks, acting as the "output channels" that directly control sets of muscles to maintain posture and generate movement. Here we use genetic mosaic techniques to reveal the origins and architec
Autor:
M Shaked-Rabi, Andy McEvoy, Sarah-Anne Martin, David J. Brierley, Paolo Salomoni, Sebastian Brandner, Susan C Short, Aikaterini Lampada, Sara Galavotti, Angela Swampillai
INTRODUCTION: Glioblastoma multiforme (GBM) remains a challenge for clinicians due to resistance to conventional treatment with the DNA-damaging agent temozolomide (TMZ) and radiation. Improving outcomes has become imperative and there is a growing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6bdc75a6618375e33c188f100f1fb0
https://europepmc.org/articles/PMC4200921/
https://europepmc.org/articles/PMC4200921/
INTRODUCTION: Mutations in the DNA mismatch repair gene MSH6 can arise in glioblastoma cells during Temozolomide treatment and can mediate drug resistance. Recently, exploiting the concept of synthetic lethality has been proposed as a therapeutic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267bfaf10795d8323bfb41d1bf71c960
https://europepmc.org/articles/PMC4200949/
https://europepmc.org/articles/PMC4200949/
Autor:
Sarah A. Martin, David J. Brierley
Publikováno v:
Antioxidantsredox signaling. 18(18)
Living organisms are under constant assault by a combination of environmental and endogenous oxidative DNA damage, inducing the modification of proteins, lipids, and DNA. Failure to resolve these oxidative modifications is associated with genome inst
Publikováno v:
PLoS Biology, Vol 7, Iss 9, p e1000199 (2009)
PLoS Biology
PLoS Biology
During development of the Drosophila motor system, global guidance cues control and coordinate the targeting of both input and output elements of the neural system.
Neural maps are emergent, highly ordered structures that are essential for organ
Neural maps are emergent, highly ordered structures that are essential for organ
Autor:
Julie A. Douthwaite, Christopher A. Brown, John R. Ferdinand, Rahul Sharma, Jane Elliott, Molly A. Taylor, Nancy T. Malintan, Hannah Duvoisin, Thomas Hill, Oona Delpuech, Alexandra L. Orton, Haidee Pitt, Fred Kuenzi, Simon Fish, David J. Nicholls, Anna Cuthbert, Ian Richards, Giles Ratcliffe, Abhishek Upadhyay, Abigail Marklew, Craig Hewitt, Douglas Ross-Thriepland, Christopher Brankin, Matthieu Chodorge, Gareth Browne, Palwinder K. Mander, Ruud M. DeWildt, Shane Weaver, Penny A. Smee, Joost van Kempen, Jon G. Bartlett, Paula M. Allen, Emma L. Koppe, Charlotte A. Ashby, Julian D. Phipps, Nalini Mehta, David J. Brierley, David G. Tew, Melanie V. Leveridge, Stuart M. Baddeley, Ian G. Goodfellow, Clive Green, Chris Abell, Andy Neely, Ian Waddell, Steve Rees, Patrick H. Maxwell, Menelas N. Pangalos, Rob Howes, Roger Clark
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate t
Externí odkaz:
https://doaj.org/article/b16f2bbb322448d5a5973467180ddaa4