Zobrazeno 1 - 10
of 569
pro vyhledávání: '"David J Beebe"'
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006424 (2017)
Externí odkaz:
https://doaj.org/article/6db9cbab9b784e9f9d87ca960da69cb4
Autor:
Kehinde Adebayo Babatunde, Rupsa Datta, Nathan W. Hendrikse, Jose M. Ayuso, Anna Huttenlocher, Melissa C. Skala, David J. Beebe, Sheena C. Kerr
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110632- (2024)
Summary: The tumor microenvironment (TME) is characterized by a network of cancer cells, recruited immune cells, and extracellular matrix (ECM). However, the specific role of neutrophils during tumor development, and their interactions with other imm
Externí odkaz:
https://doaj.org/article/f7d54eb5b2a349b387ba54a749533678
Autor:
Chad J Johnson, Jonathan Cabezas-Olcoz, John F Kernien, Steven X Wang, David J Beebe, Anna Huttenlocher, Hamayail Ansari, Jeniel E Nett
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005884 (2016)
Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, w
Externí odkaz:
https://doaj.org/article/9f616fe9cde949c8a40136c673d5fd6f
Autor:
Jennifer L Schehr, Zachery D Schultz, Jay W Warrick, David J Guckenberger, Hannah M Pezzi, Jamie M Sperger, Erika Heninger, Anwaar Saeed, Ticiana Leal, Kara Mattox, Anne M Traynor, Toby C Campbell, Scott M Berry, David J Beebe, Joshua M Lang
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159397 (2016)
Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs) may be a less invasive method to
Externí odkaz:
https://doaj.org/article/8f6661b01ec84d04955efc3f9136e5d9
Autor:
Scott M Berry, Hannah M Pezzi, Eram D Williams, Jennifer M Loeb, David J Guckenberger, Alex J Lavanway, Alice A Puchalski, Cissy M Kityo, Peter N Mugyenyi, Franklin M Graziano, David J Beebe
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143631 (2015)
Viral load (VL) measurements are critical to the proper management of HIV in developing countries. However, access to VL assays is limited by the high cost and complexity of existing assays. While there is a need for low cost VL assays, performance m
Externí odkaz:
https://doaj.org/article/e27f0af4b9674333b40c80b2912e51a7
Autor:
Nai‐Wen Liang, Carole Wilson, Brooke Davis, Ian Wolf, Tonela Qyli, Joy Moy, David J. Beebe, Lynn M. Schnapp, Sheena C. Kerr, Hilary E. Faust
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract Endothelial dysfunction is a critical feature of acute respiratory distress syndrome (ARDS) associated with higher disease severity and worse outcomes. Preclinical in vivo models of sepsis and ARDS have failed to yield useful therapies in hu
Externí odkaz:
https://doaj.org/article/0c7f74e873974e39a5cf3d8fbdddc34d
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Under-oil open microfluidic system, utilizing liquid-liquid boundaries for confinements, offers inherent advantages including clogging-free flow channels, flexible access to samples, and adjustable gas permeation, making it well-suited for s
Externí odkaz:
https://doaj.org/article/29305dd4c6ab4bf4a943fcdd5185535b
Autor:
Chao Li, Mehtab Farooqui, Ravi Chandra Yada, Joseph B. Cai, Anna Huttenlocher, David J. Beebe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract While the exquisite sensitivity of neutrophils enables their rapid response to infection in vivo; this same sensitivity complicates the ex vivo study of neutrophils. Handling of neutrophils ex vivo is fraught with unwanted heterogeneity and
Externí odkaz:
https://doaj.org/article/5375a55c664145d68deba4b3d7d68e38
Autor:
Erwin Berthier, Fang Yun Lim, Qing Deng, Chun-Jun Guo, Dimitrios P Kontoyiannis, Clay C C Wang, Julie Rindy, David J Beebe, Anna Huttenlocher, Nancy P Keller
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003289 (2013)
The secondary metabolome provides pathogenic fungi with a plethoric and versatile panel of molecules that can be deployed during host ingress. While powerful genetic and analytical chemistry methods have been developed to identify fungal secondary me
Externí odkaz:
https://doaj.org/article/8ae9616b3bbb4715a47a40d4e4c2844a
Autor:
Michael P Schwartz, Robert E Rogers, Samir P Singh, Justin Y Lee, Samuel G Loveland, Justin T Koepsel, Eric S Witze, Sara I Montanez-Sauri, Kyung E Sung, Emi Y Tokuda, Yasha Sharma, Lydia M Everhart, Eric H Nguyen, Muhammad H Zaman, David J Beebe, Natalie G Ahn, William L Murphy, Kristi S Anseth
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81689 (2013)
Here, we describe an engineering approach to quantitatively compare migration, morphologies, and adhesion for tumorigenic human fibrosarcoma cells (HT-1080s) and primary human dermal fibroblasts (hDFs) with the aim of identifying distinguishing prope
Externí odkaz:
https://doaj.org/article/41853dd457e44603a27d5bd04637c7ee