Zobrazeno 1 - 10
of 528
pro vyhledávání: '"David J Baylink"'
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115897 (2015)
The present study sought to evaluate the functional role of osteocyte-derived IGF-I in the bone repletion process by determining whether deficient expression of Igf1 in osteocytes would impair the bone repletion response to one week of dietary calciu
Externí odkaz:
https://doaj.org/article/72b5b73725c048908fb48858aeebbb5b
Autor:
Rui-Jun Su, David J Baylink, Amanda Neises, Jason B Kiroyan, Xianmei Meng, Kimberly J Payne, Benjamin Tschudy-Seney, Yuyou Duan, Nancy Appleby, Mary Kearns-Jonker, Daila S Gridley, Jun Wang, K-H William Lau, Xiao-Bing Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64496 (2013)
The ability to efficiently generate integration-free induced pluripotent stem cells (iPSCs) from the most readily available source-peripheral blood-has the potential to expedite the advances of iPSC-based therapies. We have successfully generated int
Externí odkaz:
https://doaj.org/article/c6982a0e8c094a19913fdbffa06c4590
Autor:
Bo Li, David J Baylink, Chandra Deb, Claudia Zannetti, Fatima Rajaallah, Weirong Xing, Michael H Walter, K-H William Lau, Xuezhong Qin
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58808 (2013)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) suppresses autoimmunity and inflammation; however, the mechanism of its action has not been fully understood. We sought in this study to determine whether the anti-immune/anti-inflammatory action of 1,25(OH)2D3
Externí odkaz:
https://doaj.org/article/8a44ad9fa74f4682b6958028b2fb7ebc
Publikováno v:
Cells, Vol 13, Iss 17, p 1465 (2024)
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without a cure. Current therapies suppress inflammation to prevent further intestinal damage. However, healing already damaged intestinal epithelia is still an unme
Externí odkaz:
https://doaj.org/article/4757275f462345dd8c3f153810a4a7a9
Autor:
Yi Xu, David J. Baylink, Jeffrey Xiao, Lily Tran, Vinh Nguyen, Brandon Park, Ismael Valladares, Scott Lee, Kevin Codorniz, Laren Tan, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Hamid Mirshahidi, Guido Marcucci, Huynh Cao
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8532 (2024)
Acute myeloid leukemia (AML) has a poor survival rate for both pediatric and adult patients due to its frequent relapse. To elucidate the bioenergetic principle underlying AML relapse, we investigated the transcriptional regulation of mitochondrial
Externí odkaz:
https://doaj.org/article/1dc10d5d103c4f7e84157a86199a5ee0
Autor:
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37569 (2012)
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a
Externí odkaz:
https://doaj.org/article/fca8fee70067415f88b6eec48a475046
Autor:
Matilda H-C Sheng, Jon E Wergedal, Subburaman Mohan, Mehran Amoui, David J Baylink, K-H William Lau
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35280 (2012)
This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone los
Externí odkaz:
https://doaj.org/article/b54bd79cb2024f3d8bbbac41fd76d586
Autor:
Yi Xu, David J. Baylink, Chien-Shing Chen, Laren Tan, Jeffrey Xiao, Brandon Park, Ismael Valladares, Mark E. Reeves, Huynh Cao
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Acute myeloid leukemia (AML) patients have frequent mutations in FMS-like receptor tyrosine kinase 3 (FLT3-mut AML), who respond poorly to salvage chemotherapies and targeted therapies such as tyrosine kinase inhibitors (TKIs). Disease relapse is a c
Externí odkaz:
https://doaj.org/article/04222e2a69dc42e88e95be578473bd6b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Understanding the factors which shape T-lymphocyte immunity is critical for the development and application of future immunotherapeutic strategies in treating hematological malignancies. The thymus, a specialized central lymphoid organ, plays importa
Externí odkaz:
https://doaj.org/article/3fe6b2fa0454464c816cdc5d965407f6
Autor:
Chih-Huang Li, Xiaolei Tang, Samiksha Wasnik, Xiaohua Wang, Jintao Zhang, Yi Xu, Kin-Hing William Lau, H. Bryant Nguyen, David J. Baylink
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Vitamin D deficiency, determined by blood levels of 25-hydroxyvitamin D [25(OH) D, i.e. the major vitamin D form in blood], has been shown to associate with all-cause mortalities. We recently demonstrated that blood levels of 1,25
Externí odkaz:
https://doaj.org/article/91ab2ded21b148b596b916155e69518f