Zobrazeno 1 - 10
of 33
pro vyhledávání: '"David J Augeri"'
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
John A. Gilleran, Arindam Mondal, Jacques Roberge, Michael Scott, Elaine Langenfeld, Andrew Zloza, David J. Augeri, John Langenfeld, Danea Glover, Rachel NeMoyer, Lauren Lairson, Youyi Peng
Background: Bone morphogenetic protein (BMP) is an evolutionarily conserved morphogen that is reactivated in lung carcinomas. BMP receptor inhibitors promote cell death of lung carcinomas by mechanisms not fully elucidated. The studies here reveal no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26fa0d1896b8ebc32cee2bc3155473e
https://doi.org/10.21203/rs.3.rs-20532/v2
https://doi.org/10.21203/rs.3.rs-20532/v2
Autor:
Arindam Mondal, Jacques Roberge, Michael Scott, John A. Gilleran, Elaine Langenfeld, Andrew Zloza, Rachel NeMoyer, John Langenfeld, Lauren Lairson, Danea Glover, Youyi Peng, David J. Augeri
Background: BMP is an evolutionary conserved morphogen that is reactivated in lung carcinomas. BMP receptor inhibitors promote cell death of lung carcinomas by mechanisms not fully elucidated. The studies here reveal novel mechanisms by which the “
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bed356959bff67a225add4661a03339
https://doi.org/10.21203/rs.3.rs-20532/v1
https://doi.org/10.21203/rs.3.rs-20532/v1
Autor:
Alan Wilson, Iris B. Owusu, Boteju Lakmal W, Saadat Aleem, Philip Manton Brown, Jack Yan, Theodore C. Jessop, David J. Augeri, Suman Layek, Zhong Lai, S. David Kimball, Jill Hazelwood, William Heydorn, Kenneth G. Carson, Tamas Oravecz, Liam Moran, Suma Gopinathan, Haiming Zhang, Michael S. Donoviel, Amr Nouraldeen, William K. Sonnenburg, Jeffrey T. Bagdanoff, Jeffrey A. Kramer, Alan Main, Barbara Brooks, Li Dong, James E. Tarver, Padmaja Yalamanchili, Kenny Frazier, Marianne Carlsen, Mark S. Bednarz
Publikováno v:
Journal of Medicinal Chemistry. 53:8650-8662
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87e00a9781c267b0a4f8d1324759661
https://doi.org/10.1021/jm101183p
https://doi.org/10.1021/jm101183p
Autor:
Qingyun Liu, Weimei Sun, Amr Nouraldeen, Lawrence F. Courtney, Alan Wilson, Suman Layek, Marianne Carlsen, Sean Yu, Mark S. Bednarz, Zhong Lai, Ann Marie Digeorge-Foushee, Tamas Oravecz, Jerry A. Taylor, Traci Smith, Haiming Zhang, Liam Moran, Jonathan C. Swaffield, Debra Bruce, Jill Hazelwood, Simon D.P. Baugh, David J. Augeri, Emily O’Neill, Joseph Barbosa, Kristen M. Terranova, Suma Gopinathan, Gardyan Michael Walter, Huy Van Nguyen, S. David Kimball, Jeffrey T. Bagdanoff, Jack Yan, Theodore C. Jessop, Michael S. Donoviel, Qinghong Fu, Jeffrey A. Kramer, Alan Main, James E. Tarver, Kenneth G. Carson
Publikováno v:
Journal of Medicinal Chemistry. 52:3941-3953
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL catalyzes the irreversible decomposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb6db472626b33c48fc85b6ff019d0
https://doi.org/10.1021/jm900278w
https://doi.org/10.1021/jm900278w
Autor:
David P. Rotella, Robert Zahler, David J. Augeri, Timur Gungor, Aiying Wang, William S. Slusarchyk, Scott A. Bolton, James C. Sutton, Jeffrey A. Robl, Zulan Pi, Karnail S. Atwal, Ligaya M. Simpkins, Yajun Liu, Chet Kwon, Lawrence G. Hamann, Rex A. Parker, Guohua Zhao, Mark S. Kirby, Zhong Sun, David R. Magnin, Jovita Marcinkeviciene, James G. Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6476-6480
The synthesis and structure–activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc358df323e8065d6c640de03adf2c4
https://doi.org/10.1016/j.bmcl.2007.09.090
https://doi.org/10.1016/j.bmcl.2007.09.090
Autor:
Jürgen Dinges, David A. Betebenner, Mark G. Bures, Philip J. Hajduk, Irini Zanze, Steven W. Elmore, Mary K. Joseph, Steven A. Baumeister, Stephen W. Fesik, Wang Shen, David G. Nettesheim, Shelley K. Landis, Andrew M. Petros, Sheela A. Thomas, David J. Augeri, Saul H. Rosenberg, Wang Xilu, Haichao Zhang
Publikováno v:
Journal of Medicinal Chemistry. 49:656-663
The antiapoptotic proteins Bcl-x(L) and Bcl-2 play key roles in the maintenance of normal cellular homeostasis. However, their overexpression can lead to oncogenic transformation and is responsible for drug resistance in certain types of cancer. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5d8794ba4c78441c7a9ede6d41db9b
https://doi.org/10.1021/jm0507532
https://doi.org/10.1021/jm0507532
Autor:
Shinichi Kitada, Jacqueline M. O'Connor, John C. Reed, Wendt Michael D, Andrew M. Petros, Alexander R. Shoemaker, Anatol Oleksijew, David J. Augeri, Craig B. Thompson, Kunzer Aaron R, Jürgen Dinges, Thomas L. Deckwerth, Stanley J. Korsmeyer, Saul H. Rosenberg, Stephen K. Tahir, Barbara A. Belli, Paul Nimmer, Baole Wang, Shi Chung Ng, Steven W. Elmore, Anthony Letai, Wang Shen, Haichao Zhang, Tilman Oltersdorf, Stephen W. Fesik, Milan Bruncko, David G. Nettesheim, Robert C. Armstrong, Michael J. Mitten, Kevin J. Tomaselli, Mary K. Joseph, Philip J. Hajduk, Chi Li
Publikováno v:
Nature. 435:677-681
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-X(L) and Bcl-2, are overexpressed in many cancers and contribute to tumour initiation, progression and resistance to therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b74abfc25cb335eb6b7ab85bcb7eb8
https://doi.org/10.1038/nature03579
https://doi.org/10.1038/nature03579
Autor:
Jason Allen, Kenneth G. Carson, Brian D. Hamman, Amin Al-Shami, Peter Vogel, Kanchan G. Jhaver, Carrie Wilkins, Wei-Chun Chang, Brian Zambrowicz, Kenneth A. Platt, Alan Main, Ann Marie Digeorge-Foushee, Tamas Oravecz, David J. Augeri, R. Read, Konstantin V. Salojin, Jonathan C. Swaffield, Suma Gopinathan, Theodore C. Jessop, Jeffrey T. Bagdanoff, Nita Patel, Alan Wilson, Jeannette Crisostomo, Amr Nouraldeen, Julia Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
PLoS ONE
PLoS ONE
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab72ed43ba6f3801b3c10d3473e5d2d
http://europepmc.org/articles/PMC4031148?pdf=render
http://europepmc.org/articles/PMC4031148?pdf=render
Autor:
and Stephen F. Betz, Renaldo Mendoza, Jamey Mack, Philip J. Hajduk, Stephen W. Fesik, David J. Augeri, Jianguo Yang
Publikováno v:
Journal of the American Chemical Society. 122:7898-7904
A method is described for NMR-based screening that involves monitoring the 13C/1H chemical shift changes of a protein selectively labeled with 13C at the methyl groups of valine, leucine, and isoleucine (δ1 only). Using this approach, the sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60642108bf591be70667e89ed8902e98
https://doi.org/10.1021/ja000350l
https://doi.org/10.1021/ja000350l