Zobrazeno 1 - 10
of 128
pro vyhledávání: '"David J A Wyllie"'
Autor:
Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham
Publikováno v:
eLife, Vol 6 (2017)
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it pot
Externí odkaz:
https://doaj.org/article/f177a251648f4e64b60117c9b4f5e466
Autor:
Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has
Externí odkaz:
https://doaj.org/article/ae255dae432e41748c4459655b5be30f
Autor:
Bilada Bilican, Matthew R Livesey, Ghazal Haghi, Jing Qiu, Karen Burr, Rick Siller, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85932 (2014)
Widespread use of human pluripotent stem cells (hPSCs) to study neuronal physiology and function is hindered by the ongoing need for specialist expertise in converting hPSCs to neural precursor cells (NPCs). Here, we describe a new methodology to gen
Externí odkaz:
https://doaj.org/article/71432849ec4347e083d21fefa0fd69b9
Autor:
Rickie Patani, Alastair Compston, Clare A Puddifoot, David J A Wyllie, Giles E Hardingham, Nicholas D Allen, Siddharthan Chandran
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7327 (2009)
BACKGROUND:Neural conversion from human embryonic stem cells (hESCs) has been demonstrated in a variety of systems including chemically defined suspension culture, not requiring extrinsic signals, as well as in an adherent culture method that involve
Externí odkaz:
https://doaj.org/article/e6aec00108374ac9a30074b8675a9ea2
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however
Externí odkaz:
https://doaj.org/article/3d9e90cbc8e047a6a47ce223c07a8fd8
Autor:
Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran, Matthew R. Livesey
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Background Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 re
Externí odkaz:
https://doaj.org/article/42ab8bf0a50247d5a329f4bef1e411b0
Autor:
Kosala N. Dissanayake, Joseph J. McArdle, Michael Eddleston, John E. H. Tattersall, Charlotte L. Whitmore, Filip Margetiny, Richard D. Webster, David J. A. Wyllie, David Beeson, Vishwendra Patel, Cornelia Roesl, Robert Chang-Chih Chou, Richard R. Ribchester
Publikováno v:
The Journal of Physiology. 599:5417-5449
Key points Intentional ingestion of agricultural organophosphorus insecticides is a significant public health issue in rural Asia, causing thousands of deaths annually. Survivors may develop a severe myasthenic syndrome or paralysis, associated with
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Anstey, N J, Kapgal, V, Tiwari, S, Watson, T C, Toft, A K H, Dando, O R, Inkpen, F H, Baxter, P S, Kozic, Z, Jackson, A D, He, X, Nawaz, M S, Kayenaat, A, Bhattacharya, A, Wyllie, D J A, Chattarji, S, Wood, E R, Hardt, O & Kind, P C 2022, ' Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism ', Molecular Autism, vol. 13, 34 . https://doi.org/10.1186/s13229-022-00511-8
BackgroundMutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differenc
Autor:
Natasha J, Anstey, Vijayakumar, Kapgal, Shashank, Tiwari, Thomas C, Watson, Anna K H, Toft, Owen R, Dando, Felicity H, Inkpen, Paul S, Baxter, Zrinko, Kozić, Adam D, Jackson, Xin, He, Mohammad Sarfaraz, Nawaz, Aiman, Kayenaat, Aditi, Bhattacharya, David J A, Wyllie, Sumantra, Chattarji, Emma R, Wood, Oliver, Hardt, Peter C, Kind
Publikováno v:
Molecular autism. 13(1)
Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear
Autor:
S Chandran, Owain T. James, David J. A. Wyllie, Emma M. Perkins, Matthew R. Livesey, Chen Zhao, C Rosanne M Ausems, Jenna M. Gregory, Alessandra Cardinali, Bhuvaneish T. Selvaraj, Karen Burr, Dario Magnani, Samantha K. Barton, Giles E. Hardingham, Owen G. James, Nicholas M. Morton, Roderick N. Carter, Elaine M. Cleary, David Story, Navneet A. Vasistha
Publikováno v:
Barton, S K, Magnani, D, James, O G, Livesey, M R, Selvaraj, B T, James, O T, Perkins, E M, Gregory, J M, Cleary, E, Ausems, C R M, Carter, R, Vasistha, N A, Zhao, C, Burr, K, Story, D, Cardinali, A, Morton, N M, Hardingham, G E, Wyllie, D J A & Chandran, S 2021, ' TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model ', Brain Communications, vol. 3, no. 4, fcab255 . https://doi.org/10.1093/braincomms/fcab255
Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6d6e844edbdfe4e1fb94d4ced1ab0
https://www.pure.ed.ac.uk/ws/files/260345909/fcab255.pdf
https://www.pure.ed.ac.uk/ws/files/260345909/fcab255.pdf