Zobrazeno 1 - 10
of 400
pro vyhledávání: '"David J, Waxman"'
Publikováno v:
eLife, Vol 12 (2023)
Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation linked to sex differences in gene expression and liver disease susceptibility, but little is un
Externí odkaz:
https://doaj.org/article/685a18209ee34a928afdad8a23570443
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Spatial Frequency Domain Imaging (SFDI) can provide longitudinal, label-free, and widefield hemodynamic and scattering measurements of murine tumors in vivo. Our previous work has shown that the reduced scattering coefficient (μ′s) at 800
Externí odkaz:
https://doaj.org/article/18fcc7f6f3744fc686f14c64a248e071
Autor:
Syeda Tabassum, Anup Tank, Fay Wang, Kavon Karrobi, Cameron Vergato, Irving J. Bigio, David J. Waxman, Darren Roblyer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 294-303 (2021)
Monitoring of the in vivo tumor state to track therapeutic response in real time may help to evaluate new drug candidates, maximize treatment efficacy, and reduce the burden of overtreatment. Current preclinical tumor imaging methods have largely foc
Externí odkaz:
https://doaj.org/article/7fa8e09717924d47971fc57b42e9d0d1
Autor:
Christine N. Goldfarb, David J. Waxman
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background While nuclear transcription and RNA processing and localization are well established for protein coding genes (PCGs), these processes are poorly understood for long non-coding (lnc)RNAs. Here, we characterize global patterns of tr
Externí odkaz:
https://doaj.org/article/b8387c378282402898f47042787eceeb
Autor:
Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredo
Externí odkaz:
https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa
Autor:
Bryan J. Matthews, David J. Waxman
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-25 (2020)
Abstract Several thousand sex-differential distal enhancers have been identified in mouse liver; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization and chromatin interactions are unknown. To address
Externí odkaz:
https://doaj.org/article/5effa45b0e4541799fd6566de1a84bf5
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009588 (2021)
Sex differences in gene expression are widespread in the liver, where many autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease. Here, we compare hepatic t
Externí odkaz:
https://doaj.org/article/fc82d4d06c4b47cc84c4ba1e509db9be
Autor:
Anh Phong Tran, M. Ali Al-Radhawi, Irina Kareva, Junjie Wu, David J. Waxman, Eduardo D. Sontag
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Metronomic chemotherapy can drastically enhance immunogenic tumor cell death. However, the mechanisms responsible are still incompletely understood. Here, we develop a mathematical model to elucidate the underlying complex interactions between tumor
Externí odkaz:
https://doaj.org/article/2d1bb7733d7847feabc802cc3989bf58
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008796 (2020)
Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased hepatic expression of hundreds of genes. This sexual dimorphism is largely determined by th
Externí odkaz:
https://doaj.org/article/48aafacea2d941c3beb3424299fae71f
Autor:
Tisha Melia, David J Waxman
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242665 (2020)
Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease susceptibility. While the regulation of liver sex differences by growth hormone-activated STAT5 is we
Externí odkaz:
https://doaj.org/article/27167faf56fa4bce88ecccefd3cb6df2