Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David J, Waterhouse"'
Autor:
Kevin M. Maloney, Aaron M. Whittaker, David J. Waterhouse, Neil A. Strotman, Mark A. Huffman, Sumei Ren, Christopher C. Nawrat, Hao Yang
Publikováno v:
Organic Process Research & Development. 25:516-521
We report the synthesis of the carbon-14-labeled unnatural nucleoside islatravir, an investigational HIV drug, through a one-pot biocatalytic cascade starting from acetaldehyde-2-14C. Combining enz...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc0fa76d86e44cb8a5e9430984cb30e7
https://doi.org/10.1021/acs.oprd.0c00476
https://doi.org/10.1021/acs.oprd.0c00476
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:294-296
Tritium tracers are frequently used in biological assays during the drug discovery process because of their high specific activity and relative ease of synthesis. However, this high specific activity, along with other contributing factors, can lead t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7dfb833be427e3ac74fb10638a9f09
https://doi.org/10.1002/jlcr.3394
https://doi.org/10.1002/jlcr.3394
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:261-263
Tritium radiopharmaceuticals are often used in drug development because of their desirable specific activity. The inherent instability of these radioactive tracers often leads to a requirement to purify prior to use. Purification methodologies such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c51a6510c6ee18546296147d4efe189
https://doi.org/10.1002/jlcr.3292
https://doi.org/10.1002/jlcr.3292
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:177-179
Metformin is currently prescribed worldwide to treat type 2 diabetes, and therefore, radiolabeled [(14) C] metformin is often prepared for clinical comparisons of new drug candidates. Prior to using the radiolabeled metformin, the purity needs to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ce9397c22a4af8ddc3988836c0b2158
https://doi.org/10.1002/jlcr.3264
https://doi.org/10.1002/jlcr.3264
Publikováno v:
Journal of Analytical Sciences, Methods and Instrumentation. :167-172
With the ever increasing complexity of active pharmaceutical ingredient (API) preparations, more potential genotoxic impurities (PGI’s) are being observed. It is thus necessary to determine if these PGI’s are present in the final API’s, and if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::895a8a657af2cbfa1859c18109c195de
https://doi.org/10.4236/jasmi.2013.33021
https://doi.org/10.4236/jasmi.2013.33021
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 59(7)
Tritium tracers are frequently used in biological assays during the drug discovery process because of their high specific activity and relative ease of synthesis. However, this high specific activity, along with other contributing factors, can lead t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d29308605dac46465d8b4a778ee0a53
https://pubmed.ncbi.nlm.nih.gov/27061331
https://pubmed.ncbi.nlm.nih.gov/27061331
Autor:
Larry K. Keefer, David J. Waterhouse, Joseph Ivanic, Jack R. Collins, Gwendolyn N. Chmurny, John R. Klose, Yan Ni Wang, Judith L. Flippen-Anderson, D. Scott Bohle, Joseph E. Saavedra, Challice L. Bonifant, Keith M. Davies, Jeffrey R. Deschamps
Publikováno v:
Journal of the American Chemical Society. 127:5388-5395
Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R(1)R(2)NN(O)=NOR(3). Reported crystallographic studies have uniformly revealed the Z configuration, and our attempts to observe a Z --> E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475adce6238de539094708cab5840fd0
https://doi.org/10.1021/ja042258l
https://doi.org/10.1021/ja042258l
Autor:
David J. Waterhouse, A. Paul Krapcho
Publikováno v:
Synthetic Communications. 28:3415-3422
Treatment of fluoroanthracene-9,10-diones, fluorobenz[g]isoquinoline-5,10-diones and 1- or 4-fluoronitrobenzenes with sodium trimethylsilanoate in THF followed by acidification readily yields the corresponding hydroxyl analogues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c442899db0c5e24060609242227f6b
https://doi.org/10.1080/00397919808004449
https://doi.org/10.1080/00397919808004449
Autor:
A. Paul Krapcho, Ernesto Menta, Abdelhakim Hammach, David J. Waterhouse, Silvano Spinelli, Ambrogio Oliva, Roberto Di Domenico
Publikováno v:
Scopus-Elsevier
Benzylic zinc reagents add with high regioselectivity to 1-(phenoxycarbonyl) salts of methyl nicotinate to yield methyl-1-(phenoxylcarbonyl)-4-benzyl-1,4-dihydronicotinates. The dihydronicotinates on heating with sulfur in decalin afford methyl 4-ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e54ceea66fb5b851b812963ff19dcc
https://doi.org/10.1080/00397919708004198
https://doi.org/10.1080/00397919708004198
ChemInform Abstract: General Synthetic Pathway to Oxygenated 3-Methylbenz[g]isoquinoline-5,10-diones
Autor:
David J. Waterhouse, A. Paul Krapcho
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66684f9dc5cffa558091ab92c25058ac
https://doi.org/10.1002/chin.199930162
https://doi.org/10.1002/chin.199930162