Zobrazeno 1 - 10
of 63
pro vyhledávání: '"David J, Venzon"'
Autor:
Blaire E. Barton, Matthew K. Collins, Cindy H. Chau, Hyoyoung Choo-Wosoba, David J. Venzon, Christian Steinebach, Kathleen M. Garchitorena, Bhruga Shah, Eric L. Sarin, Michael Gütschow, William D. Figg
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 725 (2024)
Immunomodulatory imide drugs (IMiDs) play a crucial role in the treatment landscape across various stages of multiple myeloma. Despite their evident efficacy, some patients may exhibit primary resistance to IMiD therapy, and acquired resistance commo
Externí odkaz:
https://doaj.org/article/d74ba37251e44718a94b951da86fbe1b
Autor:
Guillaume Joe Pegna, Min‐Jung Lee, Cody J. Peer, Mehwish I. Ahmad, David J. Venzon, Yunkai Yu, Akira Yuno, Seth M. Steinberg, Liang Cao, William D. Figg, Renee N. Donahue, Raffit Hassan, Ira Pastan, Jane B. Trepel, Christine Alewine
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4236-4249 (2023)
Abstract LMB‐100 is a novel immune‐conjugate (immunotoxin) that targets mesothelin. A phase 1/2 clinical trial was conducted (NCT02810418) with primary objectives assessing the safety and efficacy of LMB‐100 ± nab‐paclitaxel. Participant blo
Externí odkaz:
https://doaj.org/article/b0426dc9f76e4ee5ac65fe73a10166c9
Autor:
Massimiliano Bissa, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, Mohammad Arif Rahman, Saori Fujiwara, Monica Vaccari, Jeffrey A. Tomalka, James D. Stamos, Luca Schifanella, Giacomo Gorini, Ramona Moles, Anna Gutowska, Guido Ferrari, Alexei Lobanov, David C. Montefiori, George W. Nelson, Margaret C. Cam, Marita Chakhtoura, Elias K. Haddad, Melvin N. Doster, Katherine McKinnon, Sophia Brown, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Leonid Margolis, Rafick P. Sekaly, Gordon L. Hager, Genoveffa Franchini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as co
Externí odkaz:
https://doaj.org/article/f273918f9336463f8dcd9cedb0b73046
Autor:
Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolò Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N’guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1662 (2023)
At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in macaques. Vac
Externí odkaz:
https://doaj.org/article/c79e712a0eef406bace853be5af64634
Autor:
Sarah N. Fuller, Ahmad Shafiei, David J. Venzon, David J. Liewehr, Michal Mauda Havanuk, Maran G. Ilanchezhian, Maureen Edgerly, Victoria L. Anderson, Elliot B. Levy, Choung D. Hoang, Elizabeth C. Jones, Karlyne M. Reilly, Brigitte C. Widemann, Bradford J. Wood, Hadi Bagheri, Jaydira Del Rivero
Publikováno v:
Current Oncology, Vol 28, Iss 6, Pp 4357-4366 (2021)
Adrenocortical carcinoma (ACC) is a rare malignancy with an overall unfavorable prognosis. Clinicians treating patients with ACC have noted accelerated growth in metastatic liver lesions that requires rapid intervention compared to other metastatic l
Externí odkaz:
https://doaj.org/article/2219f8db788e4b979d9c5d218e3475d9
Autor:
Renee N Donahue, Jeffrey Schlom, James L Gulley, Caroline Jochems, Julius Strauss, Yo-Ting Tsai, Nicole J Toney, David J Venzon
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/0c567a9131c846d4aa50082499713444
Autor:
Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Maria Artesi, Massimiliano Bissa, Katherine McKinnon, Sophia Brown, Vincent Hahaut, Robyn Washington-Parks, Joshua Welsh, David J Venzon, Anna Gutowska, Melvin N Doster, Matthew W Breed, Kristin E Killoran, Joshua Kramer, Jennifer Jones, Marcin Moniuszko, Anne Van den Broeke, Cynthia A Pise-Masison, Genoveffa Franchini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010416 (2022)
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type (HTLV-1WT) or to the HTLV-1p12KO mutant unable to infect replete animals due to
Externí odkaz:
https://doaj.org/article/615eebba068a408f8b018f2bc095086a
Autor:
Ashley D. Hadjis, Natalia S. Nunes, Shanzay M. Khan, Rochelle E. Fletcher, Alessandra de Paula Pohl, David J. Venzon, Michael A. Eckhaus, Christopher G. Kanakry
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Post-transplantation cyclophosphamide (PTCy) reduces the incidence and severity of graft-versus-host disease (GVHD), thereby improving the safety and accessibility of allogeneic hematopoietic cell transplantation (HCT). We have shown that PTCy works
Externí odkaz:
https://doaj.org/article/2353e45dfe2c40c589b13c56dc2a4754
Autor:
Margherita Rosati, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Mahesh Agarwal, Jenifer Bear, Robert Burns, Xintao Hu, Eleni Korompoki, Duncan Donohue, David J. Venzon, Meletios-Athanasios Dimopoulos, George N. Pavlakis, Barbara K. Felber
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Durability of SARS-CoV-2 Spike antibody responses after infection provides information relevant to understanding protection against COVID-19 in humans. We report the results of a sequential evaluation of anti-SARS-CoV-2 antibodies in convalescent pat
Externí odkaz:
https://doaj.org/article/741a33df0ccb420fb35607c69fa3b1c0
Autor:
Margherita Rosati, Mahesh Agarwal, Xintao Hu, Santhi Devasundaram, Dimitris Stellas, Bhabadeb Chowdhury, Jenifer Bear, Robert Burns, Duncan Donohue, Laurent Pessaint, Hanne Andersen, Mark G Lewis, Evangelos Terpos, Meletios Athanasios Dimopoulos, Alexander Wlodawer, James I Mullins, David J Venzon, George N Pavlakis, Barbara K Felber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009701 (2021)
The speed of development, versatility and efficacy of mRNA-based vaccines have been amply demonstrated in the case of SARS-CoV-2. DNA vaccines represent an important alternative since they induce both humoral and cellular immune responses in animal m
Externí odkaz:
https://doaj.org/article/580a4216c5354680995d294b23a456cf