Zobrazeno 1 - 10
of 51
pro vyhledávání: '"David J, Vance"'
Autor:
Michael J. Rudolph, Simon A. Davis, H. M. Emranul Haque, David D. Weis, David J. Vance, Carol Lyn Piazza, Monir Ejemel, Lisa Cavacini, Yang Wang, M. Lamine Mbow, Robert D. Gilmore, Nicholas J. Mantis
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Outer surface protein C (OspC) plays a pivotal role in mediating tick-to-host transmission and infectivity of the Lyme disease spirochete, Borreliella burgdorferi. OspC is a helical-rich homodimer that interacts with tick salivary proteins,
Externí odkaz:
https://doaj.org/article/c08808c46b244cddb14dfe929eef3a85
Autor:
Elaheh Movahed, David J. Vance, Dylan Ehrbar, Greta Van Slyke, Jennifer Yates, Karen Kullas, Michael Rudolph, Nicholas J. Mantis
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT Decorin binding protein A (DbpA) is a surface adhesin of Borrelia burgdorferi, the causative agent of Lyme disease. While DbpA is one of the most immunogenic of B. burgdorferi’s nearly 100 lipoproteins, the B cell epitopes on DbpA recogniz
Externí odkaz:
https://doaj.org/article/5aba4f7bd997495591a6975598c95352
Autor:
H. M. Emranul Haque, Monir Ejemel, David J. Vance, Graham Willsey, Michael J. Rudolph, Lisa A. Cavacini, Yang Wang, Nicholas J. Mantis, David D. Weis
Publikováno v:
ACS Infectious Diseases. 8:2515-2528
The Lyme disease (LD) vaccine formerly approved for use in the United States consisted of recombinant outer surface protein A (OspA) from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679f608a3f20256d6f13d185b32211fa
https://doi.org/10.1021/acsinfecdis.2c00346
https://doi.org/10.1021/acsinfecdis.2c00346
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0236538 (2020)
Ricin toxin's B subunit (RTB) is a multifunctional galactose (Gal)-/N-acetylgalactosamine (GalNac)-specific lectin that promotes uptake and intracellular trafficking of ricin's ribosome-inactivating subunit (RTA) into mammalian cells. Structurally, R
Externí odkaz:
https://doaj.org/article/8b6367ccf81d40d3b8172843fa399037
Autor:
Michael J. Rudolph, Simon A. Davis, H M Emranul Haque, David D. Weis, David J Vance, Carol Lyn Piazza, Monir Ejemel, Lisa Cavacini, Yang Wang, M. Lamine Mbow, Robert D. Gilmore, Nicholas J Mantis
Outersurfaceprotein C (OspC) plays a pivotal role in mediating tick-to-host transmission and infectivity of the Lyme disease spirochete,Borreliella burgdorferi. OspC is a helical-rich homodimer that interacts with tick salivary proteins, as well as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7afeff799c470b8a3eae5dfe9a85cb20
https://doi.org/10.1101/2022.11.28.518297
https://doi.org/10.1101/2022.11.28.518297
Autor:
Yinghui Rong, Greta Van Slyke, David J Vance, Jennifer Westfall, Dylan Ehrbar, Nicholas J Mantis
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180999 (2017)
Ricin toxin's binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of ricin within mammalian cells. Structurally, RTB consists of two globular domains, each divide
Externí odkaz:
https://doaj.org/article/63bbca9885b9451daf4c5617ccea8d6c
Autor:
Timothy F. Czajka, Nicholas J. Mantis, Nilgun E. Tumer, Michael J. Rudolph, Simon A. Davis, David J. Vance, Xiao-Ping Li, Chi My Thi Nguyen
Publikováno v:
J Mol Biol
The extreme potency of the plant toxin, ricin, is due to its enzymatic subunit, RTA, which inactivates mammalian ribosomes with near-perfect efficiency. Here we characterized, at the functional and structural levels, seven alpaca single-domain antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a0a20808aba775f2bed808fcb7836c
https://doi.org/10.1016/j.jmb.2020.01.006
https://doi.org/10.1016/j.jmb.2020.01.006
Autor:
Hari P. Dulal, David J. Vance, Durga P. Neupane, Xiangcheng Chen, Jacqueline M. Tremblay, Charles B. Shoemaker, Nicholas J. Mantis, Jeongmin Song
Publikováno v:
Infection and Immunity. 90
Typhoid toxin is secreted by the typhoid fever-causing bacterial pathogen Salmonella enterica serovar Typhi and has tropism for immune cells and brain endothelial cells. Here, we generated a camelid single-domain antibody (VHH) library from typhoid t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa936fa7a70b652185e778ed215be157
https://doi.org/10.1128/iai.00515-21
https://doi.org/10.1128/iai.00515-21
Autor:
Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi My Thi Nguyen, Michael J. Rudolph, David Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis
Publikováno v:
Antibodies, Vol 7, Iss 4, p 45 (2018)
In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concer
Externí odkaz:
https://doaj.org/article/08b529d18940415d831f6223da371ea8
Publikováno v:
Toxins, Vol 9, Iss 12, p 378 (2017)
As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (VHHs) from alpacas that had been immunized with ricin antigens. In our initi
Externí odkaz:
https://doaj.org/article/5d982aa4d6ba48edbf5710e1ab5c36bc