Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David J, Tremethick"'
Autor:
Lauren Cole, Sebastian Kurscheid, Maxim Nekrasov, Renae Domaschenz, Daniel L. Vera, Jonathan H. Dennis, David J. Tremethick
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Histone variant H2A.Z has been suggested to contribute to the regulation of promoter accessibility. Here, the authors present high-depth maps of the position and accessibility of H2A.Z-containing nucleosomes for human Pol II promoters and provide evi
Externí odkaz:
https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b8
Autor:
Nur Diana Anuar, Sebastian Kurscheid, Matt Field, Lei Zhang, Edward Rebar, Philip Gregory, Thierry Buchou, Josephine Bowles, Peter Koopman, David J. Tremethick, Tatiana A. Soboleva
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolut
Externí odkaz:
https://doaj.org/article/1ac2215f698d4f058171c99f12cd4416
Autor:
Yasmin Dijkwel, David J. Tremethick
Publikováno v:
Journal of Developmental Biology, Vol 10, Iss 3, p 28 (2022)
During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to provide the basis for this morphological diversity. The way eukaryotic genomes are packaged
Externí odkaz:
https://doaj.org/article/05e2f532db5240b499b31fd165057b86
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 943-952 (2017)
Summary: Epithelial-mesenchymal transition (EMT) is a profound example of cell plasticity that is crucial for embryonic development and cancer. Although it has long been suspected that chromatin-based mechanisms play a role in this process, no master
Externí odkaz:
https://doaj.org/article/f3a57a4946854ec99f8f18862c44f015
Publikováno v:
Cells, Vol 9, Iss 4, p 867 (2020)
The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to proteins that copy, repair and express the genome. Different epigenetic-based mechanisms have b
Externí odkaz:
https://doaj.org/article/09e9afdcd4a541558a810ac246766a6d
Autor:
Tatiana A Soboleva, Brian J Parker, Maxim Nekrasov, Gene Hart-Smith, Ying Jin Tay, Wei-Quan Tng, Marc Wilkins, Daniel Ryan, David J Tremethick
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006633 (2017)
The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B appeared late in evolution and is most highly expressed in the testis followed by the brain in
Externí odkaz:
https://doaj.org/article/bd7cacc1f9b64fd79a570f756c5e1f59
Autor:
David J. Tremethick, Renae Domaschenz, Maxim Nekrasov, Sebastian Kurscheid, Daniel L. Vera, Lauren Cole, Jonathan H. Dennis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity. The histone variant H2A.Z has been shown to contribute to this regulation, but its role has remained poorly understood. Here, we prepare high-depth maps of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d409f621b8938c1aba8a6d3bb2088f25
https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b8
https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b8
Autor:
Maxim, Nekrasov, David J, Tremethick
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2351
Sequential ChIP (ChIP-reChIP) enables the characterization of the same nucleosome for two different types of modifications or histone subtypes. Here, we describe a ChIP-reChIP protocol to identify a heterotypic (asymmetric) H2A.Z-H2A-containing nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c38fd92262b99ac630abc69e9b0282d7
https://pubmed.ncbi.nlm.nih.gov/34382188
https://pubmed.ncbi.nlm.nih.gov/34382188
Autor:
Jiayu Wen, Elizabeth Paver, Tatiana A. Soboleva, Amanda Bullman, Xuanzhao Jiang, David J. Tremethick, Yu-Huan Wu, Gege Sun, Jane E. Dahlstrom
Publikováno v:
EMBO Rep
Testis-specific regulators of chromatin function are commonly ectopically expressed in human cancers, but their roles are poorly understood. Examination of 81 primary Hodgkin lymphoma (HL) samples showed that the ectopic expression of the eutherian t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79bf894a719795b9133861ce4ffa5b3
https://doi.org/10.15252/embr.202152462
https://doi.org/10.15252/embr.202152462
Autor:
Maxim Nekrasov, Jonas Paulsen, Erwan Delbarre, David J. Tremethick, Tharvesh Moideen Liyakat Ali, Marie-Odile Baudement, Sebastian Kurscheid, Philippe Collas
Publikováno v:
Nature Genetics. 51:835-843
Genomic information is selectively used to direct spatial and temporal gene expression during differentiation. Interactions between topologically associating domains (TADs) and between chromatin and the nuclear lamina organize and position chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a3ee379aa78b0c1a9453e5eec1a795
https://doi.org/10.1038/s41588-019-0392-0
https://doi.org/10.1038/s41588-019-0392-0