Zobrazeno 1 - 10
of 186
pro vyhledávání: '"David J, Segal"'
Autor:
Ulrika Beitnere, Brayan Vilanova-Cuevas, Sarah G. Christian, Clint Taylor, Elizabeth L. Berg, Nycole A. Copping, Scott V. Dindot, Jill L. Silverman, Mélanie G. Gareau, David J. Segal
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux. AS is caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the bra
Externí odkaz:
https://doaj.org/article/603c826aee6f48c298a9ce88f28aaa34
Autor:
David J. Segal
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/4b76b56c108247ca95782b28358a48db
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
An extensive arsenal of biosensing tools has been developed based on the clustered regularly interspaced short palindromic repeat (CRISPR) platform, including those that detect specific DNA sequences both in vitro and in live cells. To date, DNA imag
Externí odkaz:
https://doaj.org/article/20d965019e1643b1abd364af6fdf42ec
Autor:
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and i
Externí odkaz:
https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
Autor:
Peter Deng, Julian A. N. M. Halmai, Ulrika Beitnere, David Cameron, Michele L. Martinez, Charles C. Lee, Jennifer J. Waldo, Krista Thongphanh, Anna Adhikari, Nycole Copping, Stela P. Petkova, Ruth D. Lee, Samantha Lock, Miranda Palomares, Henriette O’Geen, Jasmine Carter, Casiana E. Gonzalez, Fiona K. B. Buchanan, Johnathan D. Anderson, Fernando A. Fierro, Jan A. Nolta, Alice F. Tarantal, Jill L. Silverman, David J. Segal, Kyle D. Fink
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a
Externí odkaz:
https://doaj.org/article/467d6e2aab3844e6b89d37a65f30a120
Autor:
Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham, David J. Segal
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-20 (2019)
Abstract Background Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Externí odkaz:
https://doaj.org/article/f99d86a8bbaf4fed912b9c90925d2dd9
Autor:
Henriette O’Geen, Ulrika Beitnere, Miranda S. Garcia, Anna Adhikari, David L. Cameron, Timothy A. Fenton, Nycole A. Copping, Peter Deng, Samantha Lock, Julian A.N.M. Halmai, Isaac J. Villegas, Jiajian Liu, Danhui Wang, Kyle D. Fink, Jill L. Silverman, David J. Segal
Publikováno v:
Molecular Therapy. 31:1088-1105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37fc565f97f8d789cc2309165788f0a
https://doi.org/10.1016/j.ymthe.2023.01.013
https://doi.org/10.1016/j.ymthe.2023.01.013
Autor:
S. Jesse Lopez, Keith Dunaway, M. Saharul Islam, Charles Mordaunt, Annie Vogel Ciernia, Makiko Meguro-Horike, Shin-ichi Horike, David J. Segal, Janine M. LaSalle
Publikováno v:
Epigenetics, Vol 12, Iss 11, Pp 982-990 (2017)
The dysregulation of genes in neurodevelopmental disorders that lead to social and cognitive phenotypes is a complex, multilayered process involving both genetics and epigenetics. Parent-of-origin effects of deletion and duplication of the 15q11-q13
Externí odkaz:
https://doaj.org/article/4fbf819a357d429da83796bc124fa9fe
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2019)
UBE3A is an E3 ubiquitin ligase encoded by an imprinted gene whose maternal deletion or duplication leads to distinct neurodevelopment disorders Angelman and Dup15q syndromes. Despite the known genetic basis of disease, how changes in copy number of
Externí odkaz:
https://doaj.org/article/3cfcdbf6bb18487eac83b3e30394aed7
Autor:
Maxine Umeh-Garcia, Henriette O’Geen, Catalina Simion, Melanie Hayden Gephart, David J. Segal, Colleen A. Sweeney
Publikováno v:
British journal of cancer, vol 127, iss 3
Background LRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of receptor tyrosine kinases and a tumour suppressor. Decreased LRIG1 expression is consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dcc718364dec58d5541b9a5ec2a0ed
https://doi.org/10.1038/s41416-022-01812-8
https://doi.org/10.1038/s41416-022-01812-8