Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David J, Lieb"'
Autor:
Niyati Desai, Azfar Neyaz, Annamaria Szabolcs, Angela R. Shih, Jonathan H. Chen, Vishal Thapar, Linda T. Nieman, Alexander Solovyov, Arnav Mehta, David J. Lieb, Anupriya S. Kulkarni, Christopher Jaicks, Katherine H. Xu, Michael J. Raabe, Christopher J. Pinto, Dejan Juric, Ivan Chebib, Robert B. Colvin, Arthur Y. Kim, Robert Monroe, Sarah E. Warren, Patrick Danaher, Jason W. Reeves, Jingjing Gong, Erroll H. Rueckert, Benjamin D. Greenbaum, Nir Hacohen, Stephen M. Lagana, Miguel N. Rivera, Lynette M. Sholl, James R. Stone, David T. Ting, Vikram Deshpande
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high vi
Externí odkaz:
https://doaj.org/article/c26ed9e652d143d4a25413482e8fff81
Autor:
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloé Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100287- (2021)
Summary: Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-imm
Externí odkaz:
https://doaj.org/article/c08db236b856403b84bbe1685b762818
Autor:
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Accelerating Medicines Partnership RA/SLE Network, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims
Externí odkaz:
https://doaj.org/article/f1834e16a4ee4cddb44b1feb039eb118
Autor:
Tatsuya Hasegawa, Tomonori Oka, Heehwa G. Son, Valeria S. Oliver-García, Marjan Azin, Thomas M. Eisenhaure, David J. Lieb, Nir Hacohen, Shadmehr Demehri
Senescent cell accumulation has been implicated in the pathogenesis of aging-associated diseases including cancer. The mechanism that prevents the accumulation of senescent cells in aging human organs is unclear. Here, we demonstrate that a virus-imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90795758e1b727f52e2d7b48177a6069
https://doi.org/10.1101/2023.03.06.531282
https://doi.org/10.1101/2023.03.06.531282
Autor:
Johanna Dahlqvist, Charles P Fulco, John P Ray, Thomas Liechti, Carl G de Boer, David J Lieb, Thomas M Eisenhaure, Jesse M Engreitz, Mario Roederer, Nir Hacohen
Publikováno v:
Hum Mol Genet
Background: FCGR2A binds antibody–antigen complexes to regulate the abundance of circulating and deposited complexes along with downstream immune and autoimmune responses. Although the abundance of FCRG2A may be critical in immune-mediated diseases
Autor:
Jeffrey W. Clark, Lauren Matlack, Sanya Arshad, Ryan B. Corcoran, Aparna Raj Parikh, Benjamin D. Greenbaum, Colin D. Weekes, Michael J. Raabe, Lorraine C. Drapek, Jon Dubois, Theodore S. Hong, David P. Ryan, David T. Ting, Lipika Goyal, Bronwen Foreman, Bruce J. Giantonio, Leilana Ly, Hannah Thel, Arnav Mehta, Lawrence S. Blaszkowsky, Nir Hacohen, Andrew X. Zhu, Jennifer Y. Wo, David Hoyos, Ryan D. Nipp, Emily E. Van Seventer, Jill N. Allen, Annamaria Szabolcs, Jessica A. Meurer, David J. Lieb, Beow Y. Yeap
Publikováno v:
Nature Cancer. 2:1124-1135
Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable (MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains challenging. We conducted a single-arm, non-randomized, phase II trial (NCT03104
Autor:
Joelle Brown, Hannah K. Drescher, Jenna L. Gustafson, Marcos Damasio, Sonu Subudhi, W. Nicholas Haining, David Wolski, Georg M. Lauer, Lucile Massenet-Regad, Maxwell Robidoux, Pierre Tonnerre, Daniel Kvistad, Jihad Aljabban, Arthur Y. Kim, Todd M. Allen, Jasneet Aneja, Lia Laura Lewis-Ximenez, James A. Cheney, Raymond T. Chung, David J. Bean, Damien C. Tully, Nir Hacohen, Nadia Alatrakchi, Thomas Eisenhaure, David J. Lieb, Lea M. Bartsch, Almudena Torres-Cornejo, Ruben C. Hoogeveen, Ang Cui, Debattama R. Sen
Publikováno v:
Nature Immunology. 22:1030-1041
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasiv
Autor:
Tatsuya Hasegawa, Tomonori Oka, Heehwa G. Son, Valeria S. Oliver-García, Marjan Azin, Thomas M. Eisenhaure, David J. Lieb, Nir Hacohen, Shadmehr Demehri
Publikováno v:
Cell. 186:1417-1431.e20
Autor:
Tatsuya Hasegawa, Tomonori Oka, Heehwa G. Son, Marjan Azin, Thomas M. Eisenhaure, David J. Lieb, Nir Hacohen, Shadmehr Demehri
Publikováno v:
SSRN Electronic Journal.
Autor:
Blair A. Parry, Justin D. Margolin, Carl L. Lodenstein, Ida Grundberg, Kendall M. Lavin-Parsons, David J. Lieb, Brian M. Lin, Moshe Sade-Feldman, Amanda S. Zajac, Hargun K. Khanna, Karin Pelka, Roby P. Bhattacharyya, Arnav Mehta, Christopher Smillie, Michael R. Filbin, Maricarmen Rojas-Lopez, Brian C. Russo, Graham Heimberg, Marcia B. Goldberg, Brenna N. McKaig, Miguel Reyes, Paul Hoover, Alexandra-Chloé Villani, Jessica Tantivit, Nicole C. Charland, Nihaarika Sharma, Kasidet Manakongtreecheep, Molly Thomas, Irena Gushterova, Jamey R. Guess, Robert E. Gerszten, Bánk G. Fenyves, Debby Ngo, Brendan M. Lilley, Kyle R. Kays, Thomas E. Wood, Anna L.K. Gonye, Alexis M. Schneider, Matteo Gentili, Avinash Waghray, Nir Hacohen, Thomas J. LaSalle, Lori L. Jennings
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100287-(2021)
Elsevier
Cell Reports Medicine
Elsevier
Cell Reports Medicine
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune prote