Zobrazeno 1 - 10
of 288
pro vyhledávání: '"David J, Hughes"'
Autor:
Neil Daniel, Riccardo Farinella, Anastasia Chrysovalantou Chatziioannou, Mazda Jenab, Ana-Lucia Mayén, Cosmeri Rizzato, Flavia Belluomini, Federico Canzian, Arianna Tavanti, Pekka Keski-Rahkonen, David J. Hughes, Daniele Campa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) has high mortality and rising incidence rates. Recent data indicate that the gut microbiome and associated metabolites may play a role in the development of PDAC. To complement and inform observational
Externí odkaz:
https://doaj.org/article/da2d98f474ff4bada2734a28ec4ef6e1
Publikováno v:
Animal Microbiome, Vol 6, Iss 1, Pp 1-18 (2024)
Abstract Animal guts contain numerous microbes, which are critical for nutrient assimilation and pathogen defence. While corals and other Cnidaria lack a true differentiated gut, they possess semi-enclosed gastrovascular cavities (GVCs), where vital
Externí odkaz:
https://doaj.org/article/882befa2891e4f1885a895768785a772
Autor:
Hadley England, Andrei Herdean, Jennifer Matthews, David J. Hughes, Christine D. Roper, David J. Suggett, Christian R. Voolstra, Emma F. Camp
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Organismal phenotyping to identify fitness traits is transforming our understanding of adaptive responses and ecological interactions of species within changing environments. Here we present a portable Multi-Taxa Phenotyping (MTP) system tha
Externí odkaz:
https://doaj.org/article/15dccc1ad4714687b6dae56eaef6ec51
Autor:
Radoslaw Lukoszek, Francisco Inesta-Vaquera, Natasha J.M. Brett, Shang Liang, Lydia A. Hepburn, David J. Hughes, Chiara Pirillo, Edward W. Roberts, Victoria H. Cowling
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114405- (2024)
Summary: The RNA cap methyltransferase CMTR1 methylates the first transcribed nucleotide of RNA polymerase II transcripts, impacting gene expression mechanisms, including during innate immune responses. Using mass spectrometry, we identify a multiply
Externí odkaz:
https://doaj.org/article/4bedcec1f7bc40c8a59a76d720e5b0ef
Publikováno v:
Pathogens, Vol 13, Iss 10, p 897 (2024)
Helicobacter pylori (H. pylori) has been implicated in colorectal carcinogenesis. Here, the association of immune responses to bacterial exposure with advancing stages of colorectal neoplasia was assessed by multiplex serology. Immunoglobulin (Ig) A
Externí odkaz:
https://doaj.org/article/486c454893ef42679a3235c8fc740d29
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e29771- (2024)
As health and safety issues emanating from human activities on terrestrial environment is becoming ever challenging, the production of Ordinary Portland Cement is identified as a key contributor. This technology threatens environmental quality by emi
Externí odkaz:
https://doaj.org/article/498853fb5f6e43dd938fb06cc316e606
Autor:
Luisa Galati, Purnima Gupta, Antonio Tufaro, Mariarosaria Marinaro, Concetta Saponaro, David Israel Escobar Marcillo, Donato Loisi, Rajdip Sen, Alexis Robitaille, Rosario N. Brancaccio, Cyrille Cuenin, Sandrine McKay-Chopin, Angelo Virgilio Paradiso, Václav Liška, Pavel Souček, Francesco Alfredo Zito, David J. Hughes, Massimo Tommasino, Tarik Gheit
Publikováno v:
Infectious Agents and Cancer, Vol 18, Iss 1, Pp 1-7 (2023)
Abstract Background Although the role of viral agents, such as human papillomavirus (e.g. HPV16, HPV18) in colorectal cancer (CRC) has been previously investigated, results remain inconclusive. Methods To further evaluate the involvement of oncogenic
Externí odkaz:
https://doaj.org/article/6b68842a603b48a9ac7b98a65fce0ab6
Autor:
Jennifer L. Matthews, Lilian Hoch, Jean-Baptiste Raina, Marine Pablo, David J. Hughes, Emma F. Camp, Justin R. Seymour, Peter J. Ralph, David J. Suggett, Andrei Herdean
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Symbiodiniaceae form associations with extra- and intracellular bacterial symbionts, both in culture and in symbiosis with corals. Bacterial associates can regulate Symbiodiniaceae fitness in terms of growth, calcification and photophysiolog
Externí odkaz:
https://doaj.org/article/aa51e9fd2c184ffaa848145264fcd520
Intra‐colony spatial variance of oxyregulation and hypoxic thresholds for key Acropora coral species
Autor:
Nicole J. Dilernia, Stephen Woodcock, Emma F. Camp, David J. Hughes, Michael Kühl, David J. Suggett
Publikováno v:
Ecology and Evolution, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Oxygen (O2) availability is essential for healthy coral reef functioning, yet how continued loss of dissolved O2 via ocean deoxygenation impacts performance of reef building corals remains unclear. Here, we examine how intra‐colony spatial
Externí odkaz:
https://doaj.org/article/93236410206c4a5484429665886bc141
Autor:
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background and aims The gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and metabolome and define the influence of the tumoral microbiota on oncological outcomes. Method
Externí odkaz:
https://doaj.org/article/12e07005f08c4eff961ce1c2bc1eb63e