Zobrazeno 1 - 10
of 295
pro vyhledávání: '"David J, Hackam"'
Autor:
Maame Efua S. Sampah, Hannah Moore, Raheel Ahmad, Johannes Duess, Peng Lu, Carla Lopez, Steve Steinway, Daniel Scheese, Zachariah Raouf, Koichi Tsuboi, Jeffrey Ding, Connor Caputo, Madison McFarland, William B. Fulton, Sanxia Wang, Meghan Wang, Thomas Prindle, Vered Gazit, Deborah C. Rubin, Samuel Alaish, Chhinder P. Sodhi, David J. Hackam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of h
Externí odkaz:
https://doaj.org/article/dd561572beec437e9141bc2d050317a4
Autor:
Zachariah Raouf, Steve N. Steinway, Daniel Scheese, Carla M. Lopez, Johannes W. Duess, Koichi Tsuboi, Maame Sampah, Daphne Klerk, Mahmoud El Baassiri, Hannah Moore, Cody Tragesser, Thomas Prindle, Jr., Sanxia Wang, Menghan Wang, Hee-Seong Jang, William B. Fulton, Chhinder P. Sodhi, David J. Hackam
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 53-70 (2024)
Background & Aims: The abdominal discomfort experienced by patients with colitis may be attributable in part to the presence of small intestinal dysmotility, yet mechanisms linking colonic inflammation with small-bowel motility remain largely unexplo
Externí odkaz:
https://doaj.org/article/4e2586e2cfd346c18313ac414ad157c4
Autor:
Johannes W. Duess, Maame E. Sampah, Carla M. Lopez, Koichi Tsuboi, Daniel J. Scheese, Chhinder P. Sodhi, David J. Hackam
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTNecrotizing enterocolitis (NEC) is a devastating disease in premature infants and the leading cause of death and disability from gastrointestinal disease in this vulnerable population. Although the pathophysiology of NEC remains incompletely
Externí odkaz:
https://doaj.org/article/f56af2fa1c104c2bac8316dca5920fef
Autor:
Peng Lu, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang, Qinjie Zhou, Hongpeng Jia, Mark L. Kovler, Andres Gonzalez Salazar, Maame Sampah, Thomas Prindle, Peter Wipf, Chhinder P. Sodhi, David J. Hackam
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that
Externí odkaz:
https://doaj.org/article/de31495f0c8949b19339b71ff987a273
Autor:
Darla R. Shores, Jennifer Fundora, Mitzi Go, Fauzia Shakeel, Sandra Brooks, Samuel M. Alaish, Jun Yang, Chhinder P. Sodhi, David J. Hackam, Allen Everett
Publikováno v:
BMC Pediatrics, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Background Necrotizing enterocolitis (NEC) is associated with significant morbidity and mortality. Serum biomarkers to aid diagnosis, such as intestinal fatty acid binding protein (IFABP) and calprotectin, are actively being investigated; ho
Externí odkaz:
https://doaj.org/article/9ac7ae7ae4ea4c30b0b16bfee85cdd7e
Autor:
Ailan Zhang, Chhinder P. Sodhi, Menghan Wang, Darla R. Shores, William Fulton, Thomas Prindle, Serena Brosten, Elizabeth O’Hare, Alexander Lau, Hua Ding, Hongpeng Jia, Peng Lu, James R. White, Justin Hui, Cynthia L. Sears, David J. Hackam, Samuel M. Alaish
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 309-326 (2020)
Background & Aims: In short-bowel syndrome (SBS), inadequate intestinal adaptation is responsible for the majority of complications, including sepsis, liver failure, and death. In this study, we sought to further delineate the adaptive response to id
Externí odkaz:
https://doaj.org/article/15dd3e70bd254b48b21d0bb9620d1366
Autor:
Adam D. Werts, William B. Fulton, Mitchell R. Ladd, Ali Saad-Eldin, Yue X. Chen, Mark L. Kovler, Hongpeng Jia, Emilyn C. Banfield, Rachael H. Buck, Karen Goehring, Thomas Prindle, Jr., Sanxia Wang, Qinjie Zhou, Peng Lu, Yukihiro Yamaguchi, Chhinder P. Sodhi, David J. Hackam
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 403-423 (2020)
Background & Aims: Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and enterocyte death. Given that necroptosis is a proinflammatory cell dea
Externí odkaz:
https://doaj.org/article/017b3651f54e4669b1c5d15d6678f2c2
Autor:
Lili Chen, Valentina Strohmeier, Zhengxiang He, Madhura Deshpande, Jovani Catalan-Dibene, Scott K. Durum, Thomas M. Moran, Thomas Kraus, Huabao Xiong, Jeremiah J. Faith, Chhinder P. Sodhi, David J. Hackam, Sergio A. Lira, Glaucia C. Furtado
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes m
Externí odkaz:
https://doaj.org/article/150545e2c5bb47c5b26ec7e4a3893f65
Autor:
Maame Efua S. Sampah, David J. Hackam
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Prior to birth, the neonate has limited exposure to pathogens. The transition from the intra-uterine to the postnatal environment initiates a series of complex interactions between the newborn host and a variety of potential pathogens that persist ov
Externí odkaz:
https://doaj.org/article/a1c0ebfc26464ec3966675013808e0ca
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 6 (2020)
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants and remains stubbornly difficult to treat in many cases. Much of our understanding of NEC pathogenesis has been gained through the study
Externí odkaz:
https://doaj.org/article/9de41b032529457a98d9d0019eda0eda