Zobrazeno 1 - 10
of 126
pro vyhledávání: '"David J, Grieve"'
Publikováno v:
Cells, Vol 13, Iss 14, p 1196 (2024)
The incidence of cardiovascular disorders is continuously rising, and there are no effective drugs to treat diabetes-associated heart failure. Thus, there is an urgent need to explore alternate approaches, including natural plant extracts, which have
Externí odkaz:
https://doaj.org/article/8befd4bee6274382a2a2c5d9752b0da3
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arteri
Externí odkaz:
https://doaj.org/article/a8eb7a938da94f0fbc793be40b8dc476
Autor:
Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors
Externí odkaz:
https://doaj.org/article/b856289dee3f46f7953a233bb72c1adc
Autor:
Linan Xu, Fiachra Humphries, Nezira Delagic, Bingwei Wang, Ashling Holland, Kevin S. Edgar, Jose R. Hombrebueno, Donna Beer Stolz, Ewa Oleszycka, Aoife M. Rodgers, Nadezhda Glezeva, Kenneth McDonald, Chris J. Watson, Mark T. Ledwidge, Rebecca J. Ingram, David J. Grieve, Paul N. Moynagh
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein with roles in early development, activation of the transcription factor NF-κB, and production of mitochondrial reactive oxygen species (mROS) that facilitates clea
Externí odkaz:
https://doaj.org/article/0345bb89fc434b80b4c4d1233fd83303
Autor:
Abdelrahim Alqudah, Kelly-Ann Eastwood, Djurdja Jerotic, Naomi Todd, Denise Hoch, Ross McNally, Danilo Obradovic, Stefan Dugalic, Alyson J. Hunter, Valerie A. Holmes, David R. McCance, Ian S. Young, Chris J. Watson, Tracy Robson, Gernot Desoye, David J. Grieve, Lana McClements
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play a key ro
Externí odkaz:
https://doaj.org/article/9da5fae60d9f4499b0224a5b05a2dc78
Autor:
Heloise Mongue-Din, PharmD, PhD, Ashish S. Patel, PhD, Yee H. Looi, PhD, David J. Grieve, PhD, Narayana Anilkumar, PhD, Alexander Sirker, PhD, Xuebin Dong, MD, PhD, Alison C. Brewer, PhD, Min Zhang, MD, PhD, Alberto Smith, PhD, Ajay M. Shah, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 688-698 (2017)
The reactive oxygen species–generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline,
Externí odkaz:
https://doaj.org/article/d60b1b16e8464ba19d64e415d371d213
Autor:
Karla M. O’Neill, David J. Grieve
Publikováno v:
Cardiovascular Drugs and Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f58f1671a84e3aa0b730907d43b3fce
https://doi.org/10.1007/s10557-023-07462-z
https://doi.org/10.1007/s10557-023-07462-z
Autor:
David J. Grieve, Barbara J. McDermott, Ajay M. Shah, Michelle B. Hookham, Adam P. Harvey, Emma Robinson, Declan McLaughlin, Youyou Zhao
Supplementary Methods, Figures 1-4 from Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c7109497534dbf8069baff02d2bfe8
https://doi.org/10.1158/0008-5472.22388346
https://doi.org/10.1158/0008-5472.22388346
Autor:
Gerard M. Walls, Mihaela Ghita, Rachel Queen, Kevin S. Edgar, Eleanor K. Gill, Refik Kuburas, David J. Grieve, Chris J. Watson, Alan McWilliam, Marcel Van Herk, Kaye J. Williams, Aidan J. Cole, Suneil Jain, Karl T. Butterworth
Publikováno v:
Walls, G M, Ghita, M, Queen, R, Edgar, K S, Gill, E K, Kuburas, R, Grieve, D J, Watson, C J, McWilliam, A, Van Herk, M, Williams, K J, Cole, A J, Jain, S & Butterworth, K T 2023, ' Spatial gene expression changes in the mouse heart after base-targeted irradiation ', International Journal of Radiation Oncology Biology Physics, vol. 115, no. 2, pp. 453-463 . https://doi.org/10.1016/j.ijrobp.2022.08.031
International Journal of Radiation Oncology Biology Physics, 115(2), 453-463. Elsevier Inc.
International Journal of Radiation Oncology Biology Physics, 115(2), 453-463. Elsevier Inc.
Purpose: Radiation cardiotoxicity (RC) is a clinically significant adverse effect of treatment for patients with thoracic malignancies. Clinical studies in lung cancer have indicated that heart substructures are not uniformly radiosensitive, and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c322830095dcc79b6d9b7def15018c
https://pure.qub.ac.uk/en/publications/77fa0ddf-058e-46fb-aee7-76ef9cb31b55
https://pure.qub.ac.uk/en/publications/77fa0ddf-058e-46fb-aee7-76ef9cb31b55