Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David J, Dowling"'
Autor:
Jacob A. Koster, Alejandra Prevost-Reilly, Dheeraj Soni, Aisling Kelly, Kristina Walker, Elizabeth B. Norton, Ofer Levy, Colin N. Haile, David J. Dowling
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103402- (2024)
Summary: Enzyme-linked immunosorbent assay (ELISA) offers an effective, inexpensive, and reliable approach for the analysis of humoral immune responses. Here, we describe a protocol for measuring anti-fentanyl antibodies generated by the immunization
Externí odkaz:
https://doaj.org/article/151a09bfc77b45d8b831f42d4904b4e9
Autor:
Simone S. Schüller, Soumik Barman, Raul Mendez-Giraldez, Dheeraj Soni, John Daley, Lindsey R. Baden, Ofer Levy, David J. Dowling
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Vaccination reduces morbidity and mortality due to infections, but efficacy may be limited due to distinct immunogenicity at the extremes of age. This raises the possibility of employing adjuvants to enhance immunogenicity and protection. Ea
Externí odkaz:
https://doaj.org/article/5ba84af9bf7d4964bbe1bb08f5ca9fae
Autor:
Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi, Célia Lebas, Floriane Auderset, Yamile Lugo-Rodriguez, Guzman Sanchez-Schmitz, David J. Dowling, Ofer Levy, Simon D. van Haren
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Adjuvants can enhance vaccine immunogenicity, but their mechanism of action is often incompletely understood, hampering rapid applicability for pandemic vaccines. Herein, we characterized the cellular and molecular activity of adjuvant formu
Externí odkaz:
https://doaj.org/article/2f2d3c26cb064f4eb1447fb952873fcf
Autor:
Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R. O’Meara, Marisa E. McGrath, Yoshine Saito, Jing Chen, Joann Diray-Arce, Kijun Song, Andrew Z. Xu, Soumik Barman, Manisha Menon, Danica Dong, Timothy M. Caradonna, Jared Feldman, Blake M. Hauser, Aaron G. Schmidt, Lindsey R. Baden, Robert K. Ernst, Carly Dillen, Jingyou Yu, Aiquan Chang, Luuk Hilgers, Peter Paul Platenburg, Sirano Dhe-Paganon, Dan H. Barouch, Al Ozonoff, Ivan Zanoni, Matthew B. Frieman, David J. Dowling, Ofer Levy
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits
Externí odkaz:
https://doaj.org/article/1cc5213015424ab48d02bcd22247ff42
Autor:
David J. Dowling, Soumik Barman, Alyson J. Smith, Francesco Borriello, Danielle Chaney, Spencer E. Brightman, Gandolina Melhem, Byron Brook, Manisha Menon, Dheeraj Soni, Simone Schüller, Karthik Siram, Etsuro Nanishi, Hélène G. Bazin, David J. Burkhart, Ofer Levy, Jay T. Evans
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and childhood, but in some cases the fu
Externí odkaz:
https://doaj.org/article/664c1c1f13a04a379a816fa55d3b47b1
Autor:
Katherine Chew, Branden Lee, Al Ozonoff, Jennifer A. Smith, Ofer Levy, David J. Dowling, Simon Van Haren
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102405- (2023)
Summary: High-throughput screening is a powerful platform that can rapidly provide valuable cytotoxic, immunological, and phenotypical information for thousands of compounds. Human peripheral blood mononuclear cells (PBMCs) cultured in autologous pla
Externí odkaz:
https://doaj.org/article/2e4a3daf108f4b7b925cbe4a4d3dce1f
Autor:
Etsuro Nanishi, Marisa E. McGrath, Timothy R. O’Meara, Soumik Barman, Jingyou Yu, Huahua Wan, Carly A. Dillen, Manisha Menon, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Byron Brook, Anna-Nicole Bosco, Francesco Borriello, Robert K. Ernst, Dan H. Barouch, Sirano Dhe-Paganon, Ofer Levy, Matthew B. Frieman, David J. Dowling
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.
Externí odkaz:
https://doaj.org/article/d52fa0bab2ac445194fcb3f7a844d6ba
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1766 (2023)
Infection persists as one of the leading global causes of morbidity and mortality, with particular burden at the extremes of age and in populations who are immunocompromised or suffer chronic co-morbid diseases. By focusing discovery and innovation e
Externí odkaz:
https://doaj.org/article/8c9cd46d3b3c4079bf16a5869e892311
Autor:
Guzman Sanchez-Schmitz, Elena Morrocchi, Mitchell Cooney, Dheeraj Soni, Rahima Khatun, Paolo Palma, David J. Dowling, Ofer Levy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Infections are most frequent at the extremes of life, especially among newborns, reflecting age-specific differences in immunity. Monocytes maintain tissue-homeostasis and defence-readiness by escaping circulation in the absence of inflammat
Externí odkaz:
https://doaj.org/article/fc6a618ec201482293b0aece8b6e9c08
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Traditional vaccine development against infectious diseases has been guided by the overarching aim to generate efficacious vaccines normally indicated by an antibody and/or cellular response that correlates with protection. However, this approach has
Externí odkaz:
https://doaj.org/article/cd07f26173264f27bd9f8be52b5be5b9