Zobrazeno 1 - 10
of 257
pro vyhledávání: '"David J, Deehan"'
Autor:
Daniel Hipps, Angela Pyle, Anna L. R. Porter, Philip F. Dobson, Helen Tuppen, Conor Lawless, Oliver M. Russell, Doug M. Turnbull, David J. Deehan, Gavin Hudson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Heteroplasmic mitochondrial DNA (mtDNA) variants accumulate as humans age, particularly in the stem-cell compartments, and are an important contributor to age-related disease. Mitochondrial dysfunction has been observed in osteoporosis and s
Externí odkaz:
https://doaj.org/article/5eac97d467004ee884dd4b8ea518c00b
Autor:
Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In this report, we unde
Externí odkaz:
https://doaj.org/article/9c31b31140bb46b0badb848d45713eab
Publikováno v:
Bone & Joint Open, Vol 4, Iss 9, Pp 720-727 (2023)
Aims: Achievement of accurate microbiological diagnosis prior to revision is key to reducing the high rates of persistent infection after revision knee surgery. The effect of change in the microorganism between the first- and second-stage revision of
Externí odkaz:
https://doaj.org/article/6fd8e960a5804badab64722aebb263b5
Publikováno v:
Bone & Joint Open, Vol 3, Iss 9, Pp 692-700 (2022)
AimsThe primary aim of our study was to assess the influence of age on hip-specific outcome following total hip arthroplasty (THA). Secondary aims were to assess health-related quality of life (HRQoL) and level of activity according to age.MethodsA p
Externí odkaz:
https://doaj.org/article/f5871e82891f4f01a23190c4d3425164
Autor:
Abby Brumwell, Guillaume Aubourg, Juhel Hussain, Eleanor Parker, David J. Deehan, Sarah J. Rice, John Loughlin
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs11732213 correlates w
Externí odkaz:
https://doaj.org/article/dbe8ab957d03418090c164616d411756
Autor:
Nick D. Clement, Michelle Bardgett, Steven Galloway, Y. Jenny Baron, Karen Smith, David J. Weir, David J. Deehan
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Robotic-arm-assisted knee arthroplasty allows for more accurate component positioning and alignment and is associated with better patient-reported outcomes compared to manually performed jig-based knee arthroplasty. However, what
Externí odkaz:
https://doaj.org/article/1b1bee7be98342acb92b3423c69b1d20
Publikováno v:
Bone & Joint Open, Vol 2, Iss 2, Pp 103-110 (2021)
Aims: The primary aim is to estimate the current and potential number of patients on NHS England orthopaedic elective waiting lists by November 2020. The secondary aims are to model recovery strategies; review the deficit of hip and knee arthroplasty
Externí odkaz:
https://doaj.org/article/6c22fc9842b445fbb55593b95bdbba02
Autor:
Matt J Barter, Kathleen Cheung, Julia Falk, Andreas C Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham Neill, David J Deehan, David A. Young
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 106-119 (2021)
Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through di
Externí odkaz:
https://doaj.org/article/f3384607721b41a5a198673cf0f7c3ea
Autor:
Nicholas D. Clement, Sam Oussedik, Kamran I. Raza, Robyn F. L. Patton, Karen Smith, David J. Deehan
Publikováno v:
Bone & Joint Open, Vol 1, Iss 10, Pp 663-668 (2020)
Aims: The primary aim was to assess the rate of patient deferral of elective orthopaedic surgery and whether this changed with time during the coronavirus disease 2019 (COVID-19) pandemic. The secondary aim was to explore the reasons why patients wan
Externí odkaz:
https://doaj.org/article/3b1a256ae4c04906a660b8e2fde6587c
Publikováno v:
The Bone & Joint Journal. :47-55
Aims The aim of this study was to identify variables associated with time to revision, demographic details associated with revision indication, and type of prosthesis employed, and to describe the survival of hinge knee arthroplasty (HKA) when used f