Zobrazeno 1 - 10
of 922
pro vyhledávání: '"David J, Craik"'
Autor:
Edward K. Gilding, Mark A. Jackson, Linh T. T. Nguyen, Brett R. Hamilton, Katherine A. Farquharson, Wing L. Ho, Kuok Yap, Carolyn J. Hogg, Katherine Belov, David J. Craik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The legume albumin-1 gene family, arising after nodulation, encodes linear a- and b-chain peptides for nutrient storage and defense. Intriguingly, in one prominent legume, Clitoria ternatea, the b-chains are replaced by domains producing ult
Externí odkaz:
https://doaj.org/article/877a001d359144da9cfc624fb6cdb245
Autor:
Aurélie H. Benfield, Felicitas Vernen, Reuben S.E. Young, Ferran Nadal-Bufí, Henry Lamb, Heinz Hammerlindl, David J. Craik, Helmut Schaider, Nicole Lawrence, Stephen J. Blanksby, Sónia Troeira Henriques
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107298- (2024)
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that carry a BRAF V600E mutation. To address this problem, we investigated cyclic membrane-acti
Externí odkaz:
https://doaj.org/article/50785ac1b6184083804b7912b18f5e8f
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002620 (2024)
Animals are influenced by the season, yet we know little about the changes that occur in most species throughout the year. This is particularly true in tropical marine animals that experience relatively small annual temperature and daylight changes.
Externí odkaz:
https://doaj.org/article/874789715f1d4d28a748d2e13685c335
Autor:
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B. Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F. Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W. Craven, Balazs R. Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J. Craik, Mariana Spetea, Tao Che, David Baker, Christian W. Gruber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an unmet challenge. Here, we
Externí odkaz:
https://doaj.org/article/1f201974b4984c89a23ccc2a9cfd522a
Autor:
Priscilla Galante, Gabriel A. A. Campos, Jacqueline C. G. Moser, Danubia B. Martins, Marcia P. dos Santos Cabrera, Marisa Rangel, Luiza C. Coelho, Karina S. Simon, Veronica M. Amado, Jessica de A. I. Muller, Johannes Koehbach, Rink-Jan Lohman, Peter J. Cabot, Irina Vetter, David J. Craik, Monica C. Toffoli-Kadri, Victoria Monge-Fuentes, Jair T. Goulart, Elisabeth F. Schwartz, Luciano P. Silva, Anamelia L. Bocca, Márcia R. Mortari
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrome
Externí odkaz:
https://doaj.org/article/b67d9db1535243309705120d264359b7
Autor:
Mathias Jönsson, Marie Morin, Conan K. Wang, David J. Craik, Sandie M. Degnan, Bernard M. Degnan
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Many echinoderms form seasonal aggregations prior to spawning. In some fecund species, a spawning event can lead to population outbreaks with detrimental ecosystem impacts. For instance, outbreaks of crown-of-thorns starfish (COTS
Externí odkaz:
https://doaj.org/article/f15eb17f0e24436da6c2ee3f3bc8c0f1
Autor:
Nicole L. van der Weerden, Kathy Parisi, James A. McKenna, Brigitte M. Hayes, Peta J. Harvey, Pedro Quimbar, Sean R. Wevrett, Prem K. Veneer, Owen McCorkelle, Shaily Vasa, Rosemary Guarino, Simon Poon, Yolanda M. Gaspar, Michael J. Baker, David J. Craik, Rob B. Turner, Marc B. Brown, Mark R. Bleackley, Marilyn A. Anderson
Publikováno v:
Journal of Fungi, Vol 9, Iss 11, p 1111 (2023)
Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also have psychological and social consequences for the patient. Treatment of onychomycosis is complicated by the location of the infection under the nail plate, mea
Externí odkaz:
https://doaj.org/article/17c6269b0f7a41c0908d35e989efa532
Autor:
Yue Wu, Zhenling Cui, Yen-Hua Huang, Simon J. de Veer, Andrey V. Aralov, Zhong Guo, Shayli V. Moradi, Alexandra O. Hinton, Jennifer R. Deuis, Shaodong Guo, Kai-En Chen, Brett M. Collins, Irina Vetter, Volker Herzig, Alun Jones, Matthew A. Cooper, Glenn F. King, David J. Craik, Kirill Alexandrov, Sergey Mureev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Generic approach for rapid prototyping is essential for the progress of synthetic biology. Here the authors modify the cell-free translation system to control protein aggregation and folding and validate the approach by using single conditions for pr
Externí odkaz:
https://doaj.org/article/4f078ffc82bf47b0b496a47fa5dcdbdc
Publikováno v:
Molecules, Vol 28, Iss 7, p 3189 (2023)
Bioactive peptides are a highly abundant and diverse group of molecules that exhibit a wide range of structural and functional variation. Despite their immense therapeutic potential, bioactive peptides have been traditionally perceived as poor drug c
Externí odkaz:
https://doaj.org/article/93a1f8c1e1b74194b60f70dbf34e4b99
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5893 (2023)
Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced chemically by Fmoc solid-phase peptide synthesis. Gomesin exhibits a range of biological activit
Externí odkaz:
https://doaj.org/article/a32a883742f44dad86bb8b392a1a191f