Zobrazeno 1 - 10
of 129
pro vyhledávání: '"David J, Christini"'
Autor:
Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun, Sadaf Amin, Su-Yi Tsai, Mona Khalaj, Ting Zhou, Ryan M. Samuel, Tuo Zhang, Francis A. Ortega, Miriam Gordillo, Dorota Moroziewicz, Daniel Paull, Scott A. Noggle, Jenny Zhaoying Xiang, Lorenz Studer, David J. Christini, Geoffrey S. Pitt, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104153- (2022)
Summary: The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust in vitro derivation methods. We developed a dual SHOX2:GFP; MYH6:mCherry knock
Externí odkaz:
https://doaj.org/article/fef061437c7f48f58546ebc077cf20d3
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacol
Externí odkaz:
https://doaj.org/article/0ea4d51a30f84a319f332ff8fd449ee4
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting phenotypical consequences of ion channel mutations, but their accuracy is sometimes limited. For example, several models describing human ventricular e
Externí odkaz:
https://doaj.org/article/582cb2052ed644cda88a02e6e89bf906
Autor:
Alexander P. Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P. de Boer, Gary R. Mirams, David J. Christini, Trine Krogh-Madsen
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, and the computational models built from the resultant data, has overlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ed2bc62fb226b8bcd15bdcb5691ce2
https://doi.org/10.1101/2022.10.13.511949
https://doi.org/10.1101/2022.10.13.511949
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005430 (2017)
The ability to experimentally perturb biological systems has traditionally been limited to static pre-programmed or operator-controlled protocols. In contrast, real-time control allows dynamic probing of biological systems with perturbations that are
Externí odkaz:
https://doaj.org/article/ef075f59f68e49a7900846b09a88d561
Autor:
Kemar Brown, Stephanie Legros, Francis A Ortega, Yunkai Dai, Michael Xavier Doss, David J Christini, Richard B Robinson, Ann C Foley
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189818 (2017)
In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. H
Externí odkaz:
https://doaj.org/article/b5f7aed9224a42478ecb7be635eb5f22
Autor:
Zaniar, Ghazizadeh, Jiajun, Zhu, Faranak, Fattahi, Alice, Tang, Xiaolu, Sun, Sadaf, Amin, Su-Yi, Tsai, Mona, Khalaj, Ting, Zhou, Ryan M, Samuel, Tuo, Zhang, Francis A, Ortega, Miriam, Gordillo, Dorota, Moroziewicz, Daniel, Paull, Scott A, Noggle, Jenny Zhaoying, Xiang, Lorenz, Studer, David J, Christini, Geoffrey S, Pitt, Todd, Evans, Shuibing, Chen
Publikováno v:
iScience. 25(4)
The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d519a640ec8271ca23bd68d2f96d3e1b
https://pubmed.ncbi.nlm.nih.gov/35434558
https://pubmed.ncbi.nlm.nih.gov/35434558
New therapeutic compounds go through a preclinical drug cardiotoxicity screening process that is overly conservative and provides limited mechanistic insight, leading to the misclassification of potentially beneficial drugs as proarrhythmic. There is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42dc08e4e18502f91204172235aa60d3
https://doi.org/10.1101/2021.09.10.459625
https://doi.org/10.1101/2021.09.10.459625
Autor:
Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)
The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations
Externí odkaz:
https://doaj.org/article/955d66251d1f439a96259fddd41f95af