Zobrazeno 1 - 10
of 166
pro vyhledávání: '"David J, Chaplin"'
Autor:
Robert S. Kerbel, Daniel C. Link, Francesco Bertolini, Gordon Rustin, Ian Judson, Paul Nathan, Adrian Harris, Jon Smythe, David J. Chaplin, Emile E. Voest, Jeffrey M. Arbeit, Shi-Rong Cai, Ping Xu, Shan Man, Laura G. Daenen, Jill Woloszynek, Terence Tang, Yuval Shaked
Supplementary Figures 1-2 from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d7e4fc3a049bc155c2e82336f2d7ca
https://doi.org/10.1158/0008-5472.22378397.v1
https://doi.org/10.1158/0008-5472.22378397.v1
Autor:
Robert S. Kerbel, Daniel C. Link, Francesco Bertolini, Gordon Rustin, Ian Judson, Paul Nathan, Adrian Harris, Jon Smythe, David J. Chaplin, Emile E. Voest, Jeffrey M. Arbeit, Shi-Rong Cai, Ping Xu, Shan Man, Laura G. Daenen, Jill Woloszynek, Terence Tang, Yuval Shaked
Supplementary Methods from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b4f09a6e6ec4a2afb856bfe53d7a1
https://doi.org/10.1158/0008-5472.22378394
https://doi.org/10.1158/0008-5472.22378394
Autor:
Mary Lynn Trawick, Tracy E. Strecker, Ernest Hamel, Jeni Gerberich, Deboprosad Mondal, James W. Campbell, Kevin G. Pinney, David J. Chaplin, Haichan Niu, Ralph P. Mason, Debabrata Saha
Publikováno v:
J Med Chem
A promising design paradigm for small-molecule inhibitors of tubulin polymerization that bind to the colchicine site draws structural inspiration from the natural products colchicine and combretastatin A-4 (CA4). Our previous studies with benzocycloa
Autor:
Jeni Gerberich, Ralph P. Mason, Bunnarack Kuch, Blake A. Winn, Mary Lynn Trawick, Zhe Shi, Matthew T. MacDonough, Alejandro J. Ramirez, Tracy E. Strecker, Peter David Davis, Laxman Devkota, Yifan Wang, Ernest Hamel, Deboprosad Mondal, David J. Chaplin, Kevin G. Pinney
Publikováno v:
J Nat Prod
The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can
Autor:
Heling Zhou, Kevin G. Pinney, Yifan Wang, Tracy E. Strecker, Zhi Chen, Vani P. Mocharla, Casey J. Maguire, Ernest Hamel, David J. Chaplin, Madhavi Sriram, Ralph P. Mason, Mary Lynn Trawick, Ramona Lopez
Publikováno v:
MedChemComm. 9:1649-1662
The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a binding interaction at the colchicine
Autor:
Yifan Wang, Samuel O. Odutola, Zhe Shi, Erica Parker, Rajeswari Mukherjee, Kevin G. Pinney, David J. Chaplin, Mary Lynn Trawick, Tracy E. Strecker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1304-1310
The magnitude of expression of cathepsin L, often upregulated in the tumor microenvironment, correlates with the invasive and metastatic nature of certain tumors. Inhibition of cathepsin L represents an emerging strategy for the treatment of metastat
Autor:
Ernest Hamel, Ralph P. Mason, Alex Winters, Zhi Chen, David J. Chaplin, Christine A. Herdman, Mary Lynn Trawick, Li Liu, Tracy E. Strecker, Jeni Gerberich, Rajendra P. Tanpure, Kevin G. Pinney
Publikováno v:
MedChemComm. 7:2418-2427
The natural products colchicine and combretastatin A-4 (CA4) have been inspirational for the design and synthesis of structurally related analogues and spin-off compounds as inhibitors of tubulin polymerization. The discovery that a water-soluble pho
Autor:
Tracy E. Strecker, Chen-Ming Lin, Clinton S. George, Ernest Hamel, Christine A. Herdman, Mary Lynn Trawick, Kevin G. Pinney, Ralph P. Mason, Laxman Devkota, David J. Chaplin, Li Liu, Haichan Niu, Ramona Lopez, Rajendra P. Tanpure
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7497-7520
The discovery of 3-methoxy-9-(3′,4′,5′-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol (a benzosuberene-based analogue referred to as KGP18) was originally inspired by the natural products colchicine and combretastatin A-4 (CA4). The rela
Publikováno v:
Vascular Pharmacology. 74:73-79
Combretastatin A-4 phosphate (CA4P), a tubulin depolymerizing agent, shows promise in anti-cancer therapy and is associated with dose-dependent transient hypertension. The cardiac consequence of this hypertensive effect is unknown. This study was con
Publikováno v:
Gynecologic Oncology Research and Practice
Gynecologic Oncology Research and Practice, Vol 5, Iss 1, Pp 1-10 (2018)
Gynecologic Oncology Research and Practice, Vol 5, Iss 1, Pp 1-10 (2018)
Combretastatin A4-phosphate (CA4P) is a vascular-disrupting agent (VDA) in clinical development for the treatment of ovarian and other cancers. In contrast to antiangiogenic agents, such as bevacizumab, which suppress the development of new tumor vas