Zobrazeno 1 - 10
of 141
pro vyhledávání: '"David J, Calkins"'
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling, and both reflects and governs the physiological status of the local microenvironment. The matr
Externí odkaz:
https://doaj.org/article/a207ceef47b64a0f8c77cf84dfe821bd
Autor:
Tonia S. Rex, David J. Calkins
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 489-490 (2025)
Externí odkaz:
https://doaj.org/article/4c7ae4711bc84adf939ab1aa4482d334
Autor:
Robert O. Baratta, MD, Eric Schlumpf, BS, Brian J. Del Buono, PhD, Shawn DeLorey, George Ousler, MS, David J. Calkins, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 3, Pp 100451- (2024)
Objective: Dry eye disease (DED) is a worldwide source of ocular discomfort. This first-in-human phase 2 clinical study determined the efficacy of treating signs and symptoms of DED using an ophthalmic solution of synthesized mimetic of human collage
Externí odkaz:
https://doaj.org/article/2b566e7fa1174ae4beb799f197880305
Autor:
Michael L. Risner, Marcio Ribeiro, Nolan R. McGrady, Bhanu S. Kagitapalli, Xitiz Chamling, Donald J. Zack, David J. Calkins
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and extracellular vesicles (
Externí odkaz:
https://doaj.org/article/ba8cbac6e19c414cbb766f5391c5ec38
Autor:
Sarah Naguib, Jon R. Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A. Haider, John Ang, David J. Calkins, Tonia S. Rex
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/822803ba53aa43a396111c625495ec4e
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Astrocytes are important regulators of blood flow and play a key role in the response to injury and disease in the central nervous system (CNS). Despite having an understanding that structural changes to these cells have consequences for local neurov
Externí odkaz:
https://doaj.org/article/23fcaeeaeea84c37ab2871b516840550
Autor:
Nancy J. Newman, Matthew Schniederjan, Pia R. Mendoza, David J. Calkins, Patrick Yu-Wai-Man, Valérie Biousse, Valerio Carelli, Magali Taiel, Francois Rugiero, Pramila Singh, Alexandra Rogue, José-Alain Sahel, Philippe Ancian
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally-inherited mitochondrial disease that primarily affects retinal ganglion cells (RGCs) and their axons in the optic nerve, leading to irreversible, bilateral severe visi
Externí odkaz:
https://doaj.org/article/923f8af8163d42f2bf38d764929e4ab8
Autor:
Lauren K. Wareham, Joseph M. Holden, Olivia L. Bossardet, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, David J. Calkins
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The intraepithelial sub-basal nerve plexus of the cornea is characterized by a central swirl of nerve processes that terminate between the apical cells of the epithelium. This plexus is a critical component of maintaining homeostatic function of the
Externí odkaz:
https://doaj.org/article/9da9d9f7e3c24a5da3069e7c52b07094
Autor:
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss em
Externí odkaz:
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionIdentification of early adaptive and maladaptive neuronal stress responses is an important step in developing targeted neuroprotective therapies for degenerative disease. In glaucoma, retinal ganglion cells (RGCs) and their axons undergo
Externí odkaz:
https://doaj.org/article/6b398316a73042a495ab710828d24ef4