Zobrazeno 1 - 10
of 136
pro vyhledávání: '"David J, Bzik"'
Autor:
Hironori Bando, Yuho Murata, Yongmei Han, Tatsuki Sugi, Yasuhiro Fukuda, David J. Bzik, Barbara A. Fox, Kentaro Kato
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Toxoplasma, an important intracellular parasite of humans and animals, causes life-threatening toxoplasmosis in immunocompromised individuals. Although Toxoplasma secretory proteins during acute infection (tachyzoite, which divides rapidly and causes
Externí odkaz:
https://doaj.org/article/cc9abefb86524b48821386dd5e5ad8e4
Autor:
Joseph Lykins, Matthew J. Moschitto, Ying Zhou, Ekaterina V. Filippova, Hoang V. Le, Tadakimi Tomita, Barbara A. Fox, David J. Bzik, Chunlei Su, Seesandra V. Rajagopala, Kristin Flores, Furio Spano, Stuart Woods, Craig W. Roberts, Cong Hua, Kamal El Bissati, Kelsey M. Wheeler, Sarah Dovgin, Stephen P. Muench, Martin McPhillie, Colin W.G. Fishwick, Wayne F. Anderson, Patricia J. Lee, Mark Hickman, Louis M. Weiss, Jitender P. Dubey, Hernan A. Lorenzi, Richard B. Silverman, Rima L. McLeod
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108477- (2024)
Summary: Toxoplasma gondii causes morbidity, mortality, and disseminates widely via cat sexual stages. Here, we find T. gondii ornithine aminotransferase (OAT) is conserved across phyla. We solve TgO/GABA-AT structures with bound inactivators at 1.55
Externí odkaz:
https://doaj.org/article/4214ce2e3d344bdb89d711a4b2786ce4
Autor:
Rajesh Mani, Mohamed H. Abdelaziz, Eri Ochiai, Qila Sa, Barbara A. Fox, David J. Bzik, Yasuhiro Suzuki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Toxoplasma gondii establishes chronic infection by forming tissue cysts, and this chronic infection is one of the most common parasitic infections in humans. Our recent studies revealed that whereas CD8+ T cells of genetically resistant BALB/c mice h
Externí odkaz:
https://doaj.org/article/15463f22d29f4aff8abb0a9b91245bde
Autor:
Lee Bowman, Rachael Motamed, Paul Lee, Kadijah Aleem, Astha S Berawala, Katherine L Hayden, David J Bzik, Debasish Chattopadhyay
Publikováno v:
BioTechniques, Vol 68, Iss 4, Pp 200-203 (2020)
Determination of the optimum pH in a coupled enzyme assay poses significant challenges because altering the pH of the reaction mixture can affect the performance of both enzymes. Here, we demonstrate a simple and reliable method to determine the pH o
Externí odkaz:
https://doaj.org/article/bb7edf781d0e48d7a88e00b88cf5651f
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
If host immunity weakens, Toxoplasma gondii
Externí odkaz:
https://doaj.org/article/0b03429ca7d54605862d8bad9197a4d8
Autor:
Heather L Mercer, Lindsay M Snyder, Claire M Doherty, Barbara A Fox, David J Bzik, Eric Y Denkers
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008572 (2020)
The apicomplexan Toxoplasma gondii induces strong protective immunity dependent upon recognition by Toll-like receptors (TLR)11 and 12 operating in conjunction with MyD88 in the murine host. However, TLR11 and 12 proteins are not present in humans, i
Externí odkaz:
https://doaj.org/article/1158ee5894a54cd9af1900b0919a7d3c
Publikováno v:
mSphere, Vol 5, Iss 2 (2020)
ABSTRACT The glycosylated mucin domain of the Toxoplasma gondii cyst wall glycoprotein CST1 is heavily stained by Dolichos biflorus agglutinin, a lectin that binds to N-acetylgalactosamine. The cyst wall is also heavily stained by the chitin binding
Externí odkaz:
https://doaj.org/article/3201a1e697564c82876a056dde0c39f9
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT After differentiation is triggered, the tachyzoite-stage Toxoplasma gondii parasitophorous vacuole membrane (PVM) has been hypothesized to transition into the cyst membrane that surrounds the cyst wall and encloses bradyzoites. Here, we trac
Externí odkaz:
https://doaj.org/article/3f45c4aa406b4e6eaf55482db85eaec7
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Little is known regarding how the chronic Toxoplasma gondii cyst develops. Here, we investigated intravacuolar-network-associated dense granule (GRA) proteins GRA1, GRA2, GRA4, GRA6, GRA9, and GRA12 during cyst development in vitro after dif
Externí odkaz:
https://doaj.org/article/0dd4b654c23e49efa692482b7cda66d3
Autor:
Leah M. Rommereim, Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, David J. Bzik
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Toxoplasma gondii secretes rhoptry (ROP) and dense granule (GRA) effector proteins to evade host immune clearance mediated by interferon gamma (IFN-γ), immunity-related GTPase (IRG) effectors, and CD8+ T cells. Here, we investigated the role of para
Externí odkaz:
https://doaj.org/article/abeff253034f400bb3a7de88edd65bcc