Zobrazeno 1 - 10
of 46
pro vyhledávání: '"David J, Burkhart"'
Autor:
Konner J. Jackson, Cassandra Buhl, Shannon M. Miller, Juhienah K. Khalaf, Janine Ward, Cherrokee Sands, Lois Walsh, Margaret Whitacre, David J. Burkhart, Hélène G. Bazin-Lee, Jay T. Evans
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAtopic diseases have been steadily increasing over the past decades and effective disease-modifying treatment options are urgently needed. These studies introduce a novel synthetic Toll-like receptor 4 (TLR4) agonist, INI-2004, with remar
Externí odkaz:
https://doaj.org/article/9b60a2eb358d47ecbea880c10933a65d
Autor:
Shannon M. Miller, Bethany Crouse, Linda Hicks, Hardik Amin, Shelby Cole, Helene G. Bazin, David J. Burkhart, Marco Pravetoni, Jay T. Evans
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Opioid use disorders (OUD) and opioid-related fatal overdoses are a public health concern in the United States. Approximately 100,000 fatal opioid-related overdoses occurred annually from mid-2020 to the present, the majority of which involv
Externí odkaz:
https://doaj.org/article/1da1be1405e24b4a9876d785eb6244f4
Autor:
David J. Dowling, Soumik Barman, Alyson J. Smith, Francesco Borriello, Danielle Chaney, Spencer E. Brightman, Gandolina Melhem, Byron Brook, Manisha Menon, Dheeraj Soni, Simone Schüller, Karthik Siram, Etsuro Nanishi, Hélène G. Bazin, David J. Burkhart, Ofer Levy, Jay T. Evans
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and childhood, but in some cases the fu
Externí odkaz:
https://doaj.org/article/664c1c1f13a04a379a816fa55d3b47b1
Autor:
Walid M. Abdelwahab, Sarah Auclair, Timothy Borgogna, Karthik Siram, Alexander Riffey, Hélène G. Bazin, Howard B. Cottam, Tomoko Hayashi, Jay T. Evans, David J. Burkhart
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 107 (2024)
Co-delivery of antigens and adjuvants to the same antigen-presenting cells (APCs) can significantly improve the efficacy and safety profiles of vaccines. Here, we report amine-grafted silica nanoparticles (A-SNP) as a tunable vaccine co-delivery plat
Externí odkaz:
https://doaj.org/article/26544322b0c64072a9ae66274353b9af
Autor:
Karthik Siram, Stephanie K. Lathrop, Walid M. Abdelwahab, Rebekah Tee, Clara J. Davison, Haley A. Partlow, Jay T. Evans, David J. Burkhart
Publikováno v:
Vaccines, Vol 12, Iss 1, p 21 (2023)
Despite the availability of effective vaccines against COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide, pressing the need for new vaccines with improved breadth and durability. We developed an adju
Externí odkaz:
https://doaj.org/article/5588703beb6d4da48c23ab455bcdd91b
Autor:
Kristopher K. Short, Stephanie K. Lathrop, Clara J. Davison, Haley A. Partlow, Johnathan A. Kaiser, Rebekah D. Tee, Elizabeth B. Lorentz, Jay T. Evans, David J. Burkhart
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1455 (2022)
A diversity of vaccines is necessary to reduce the mortality and morbidity of SARS-CoV-2. Vaccines must be efficacious, easy to manufacture, and stable within the existing cold chain to improve their availability around the world. Recombinant protein
Externí odkaz:
https://doaj.org/article/dc040770076e4fe8bccc69c38335ffb0
Autor:
Luis O. De Serrano, David J. Burkhart
Publikováno v:
Journal of Nanobiotechnology, Vol 15, Iss 1, Pp 1-23 (2017)
Abstract Vaccinology is one of the most important cornerstones in modern medicine, providing better quality of life. The human immune system is composed of innate and adaptive immune processes that interplay when infection occurs. Innate immunity rel
Externí odkaz:
https://doaj.org/article/a7eb9140b44a4cf5abbbe335b0737b78
Autor:
Nobuyo Mizuno, Helene Bazin-Lee, Ahmad Junaid, Nileshkumar Meghani, Jay Nelson, Victor deFillips, David J Burkhart, Kendal Ryter, Janine M Ward, Omer rasheed, Uddav Pandey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679b3148846d87d9aeece4974d18319d
https://doi.org/10.1021/scimeetings.3c00141
https://doi.org/10.1021/scimeetings.3c00141
Autor:
Francesco Borriello, Carlo Pietrasanta, Jacqueline C. Y. Lai, Lois M. Walsh, Pankaj Sharma, David N. O’Driscoll, Juan Ramirez, Spencer Brightman, Lorenza Pugni, Fabio Mosca, David J. Burkhart, David J. Dowling, Ofer Levy
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Immunization is key to preventing infectious diseases, a leading cause of death early in life. However, due to age-specific immunity, vaccines often demonstrate reduced efficacy in newborns and young infants as compared to adults. Here, we combined i
Externí odkaz:
https://doaj.org/article/3a7316b0adc1486ea4a548622aca97e2
A tractable covalent linker strategy for the production of immunogenic antigen-TLR7/8L bioconjugates
Autor:
S K Lathrop, R Schoener, Casey J. Massena, Jay T. Evans, C J Davison, Hélène G. Bazin, David J. Burkhart
Publikováno v:
Chemical Communications. 57:4698-4701
Despite the ease of production and improved safety profiles of recombinant vaccines, the inherently low immunogenicity of unadjuvanted proteins remains an impediment to their widespread adoption. The covalent tethering of TLR agonists to antigenic pr